Immunonkologie beim triple-negativen Mammakarzinom

Anne-Sophie Heimes; Katrin Almstedt; Marcus Schmidt

doi:10.1055/a-0828-3906

Frauenheilkunde up2date, Table of Contents

Frauenheilkunde up2date 2019; 13(04): 339-349
DOI: 10.1055/a-0828-3906

Gynäkologische Onkologie

Georg Thieme Verlag KG Stuttgart · New York

Immunonkologie beim triple-negativen Mammakarzinom

Anne-Sophie Heimes

,

Katrin Almstedt

,

Marcus Schmidt

Abstract

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Die Rolle des Immunsystems beim Mammakarzinom rückt zunehmend in den Fokus immunonkologischer Forschungsprojekte. Insbesondere das triple-negative Mammakarzinom (TNBC) verfügt im Vergleich zu den anderen Tumorsubtypen über ein ausgeprägtes immunogenes Potenzial. Möglichkeiten einer immunonkologischen Therapie ergeben sich durch Immuncheckpoint-Inhibition, Vakzinierung oder adoptiven T-Zell-Transfer.

Schlüsselwörter

Immuncheckpoint-Inhibitoren - Vakzinierung - TIL - tumorinfiltrierende Lymphozyten - PD-1 - PD-L1 - Krebs-Immunzell-Zyklus

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References

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