CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2019; 79(02): 160-176
DOI: 10.1055/a-0828-7722
GebFra Science
Guideline/Leitlinie
Georg Thieme Verlag KG Stuttgart · New York

Prevention of Cervical Cancer. Guideline of the DGGG and the DKG (S3 Level, AWMF Register Number 015/027OL, December 2017) – Part 2 on Triage, Treatment and Follow-up

Artikel in mehreren Sprachen: English | deutsch
Peter Hillemanns
1   Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Hannover, Germany
,
Klaus Friese
2   Klinik Bad Trissl GmbH, Oberaudorf, Germany
,
Christian Dannecker
3   Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, München, Germany
,
Stefanie Klug
4   Lehrstuhl für Epidemiologie, Technische Universität München, München, Germany
,
Ulrike Seifert
5   Tumorepidemiologie, Universitäts KrebsCentrum (UCC), Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
Thomas Iftner
6   Institut für Medizinische Virologie und Epidemiologie der Viruskrankheiten, Universitätsklinikum Tübingen, Tübingen, Germany
,
Juliane Hädicke
6   Institut für Medizinische Virologie und Epidemiologie der Viruskrankheiten, Universitätsklinikum Tübingen, Tübingen, Germany
,
Thomas Löning
7   Institut für Pathologie, Albertinen-Krankenhaus Hamburg, Hamburg, Germany
,
Lars Horn
8   Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany
,
Dietmar Schmidt
9   Institut für Pathologie, Referenzzentrum für Gynäkopathologie, Mannheim, Germany
,
Hans Ikenberg
10   CytoMol – MVZ für Zytologie und Molekularbiologie, Frankfurt, Germany
,
Manfred Steiner
11   Facharzt für Frauenheilkunde und Geburtshilfe, Ihringen, Germany
,
Ulrich Freitag
12   Facharzt für Frauenheilkunde und Geburtshilfe, Wismar, Germany
,
Uwe Siebert
13   Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT – University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria
34   Division of Health Technology Assessment and Bioinformatics, ONCOTYROL – Center for Personalized Cancer Medicine, Innsbruck, Austria
,
Gaby Sroczynski
13   Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT – University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria
,
Willi Sauerbrei
14   Institut für Med. Biometrie und Statistik (IMBI), Universitätsklinikum Freiburg, Freiburg, Germany
,
Matthias W. Beckmann
15   Frauenklinik, Universitätsklinikum Erlangen, Erlangen, Germany
,
Marion Gebhardt
16   Frauenselbsthilfe nach Krebs, Forchheim, Germany
,
Michael Friedrich
17   Klinik für Frauenheilkunde und Geburtshilfe, Helios Klinikum Krefeld, Krefeld, Germany
,
Karsten Münstedt
18   Frauenklinik, Ortenau Klinikum Offenburg-Gengenbach, Offenburg, Germany
,
Achim Schneider
19   Medizinisches Versorgungszentrum im Fürstenberg-Karree, Berlin, Germany
,
Andreas Kaufmann
20   Klinik für Gynäkologie, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany
,
K. Ulrich Petry
21   Frauenklinik, Klinikum Wolfsburg, Wolfsburg, Germany
,
Axel P. A. Schäfer
22   Facharzt für Frauenheilkunde und Geburtshilfe, Berlin, Germany
,
Michael Pawlita
23   Deutsches Krebsforschungszentrum, Heidelberg, Germany
,
Joachim Weis
24   Klinik für Tumorbiologie, Klinik für Onkologische Rehabilitation – UKF Reha gGmbH, Freiburg, Germany
,
Anja Mehnert
25   Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig, Leipzig, Germany
,
Mathias Fehr
26   Gynäkologie & Geburtshilfe in Frauenfeld, Spital Thurgau AG, Frauenfeld, Switzerland
,
Christoph Grimm
27   Privatklinik Döbling, Wien, Austria
,
Olaf Reich
28   Privatklinik Graz Ragnitz, Graz, Austria
,
Marc Arbyn
29   Cancer Center, Sciensano, Brüssel, Belgium
,
Jos Kleijnen
30   Kleijnen Systematic Reviews Ltd, York, United Kingdom
,
Simone Wesselmann
31   Deutsche Krebsgesellschaft, Berlin, Germany
,
Monika Nothacker
32   AWMF-Institut für Medizinisches Wissensmanagement, Marburg, Germany
,
Markus Follmann
33   Leitlinienprogramm Onkologie, Deutsche Krebsgesellschaft, Berlin, Germany
,
Thomas Langer
33   Leitlinienprogramm Onkologie, Deutsche Krebsgesellschaft, Berlin, Germany
,
Matthias Jentschke
1   Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Hochschule Hannover, Hannover, Germany
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Publikationsverlauf

received 21. August 2018
revised 20. Dezember 2018

accepted 20. Dezember 2018

Publikationsdatum:
18. Februar 2019 (online)

Abstract

Aims Annual opportunistic screening for cervical carcinoma has been done in Germany since 1971. The creation of this S3 guideline meets an important need, outlined in the National Cancer Plan, with regard to screening for cervical cancer, as this guideline aims to provide important information and support for planned organized screening for cervical cancer in Germany.

Methods With the financial support of German Cancer Aid, 21 professional societies developed evidence-based statements and recommendations (classified using the GRADE system) for the screening, management and treatment of precancerous conditions of the cervix. Two independent scientific institutes compiled systematic reviews for this guideline.

Recommendations The second part of this short summary deals with the triage, treatment and follow-up care of cervical dysplasia. With regard to those women who do not participate in screening, the guideline authors recommend sending out repeat invitation letters or an HPV self-collection kit. Colposcopy should be carried out for further investigation if cytology findings are Pap II-p and HPV test results are positive or if the results of an HPV 16 or HPV 18 screening test are positive. A single abnormal Pap smear should be triaged and investigated using HPV testing or p16/Ki67 dual staining.

 
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