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Dtsch Med Wochenschr 2019; 144(16): 1111-1119
DOI: 10.1055/a-0841-8336
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© Georg Thieme Verlag KG Stuttgart · New York

Personalisierte Osteoporose-Therapie

Personalized Therapy In Osteoporosis
Karoline Schulz
,
Hannes Kalscheuer
,
Hendrik Lehnert
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Publication History

Publication Date:
15 August 2019 (online)

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Abstract

In Germany, over six million people suffer from osteoporosis. Nearly half of the women over 70 years and nearly 20 % of men at the same age are affected. The clinical and socioeconomical relevance of the disease lies in osteoporotic fractures leading to extensive bone-associated morbidity, increased mortality and health care costs. Fracture risk algorithms and guidelines for the diagnosis and treatment of osteoporosis help to assess the individual fracture risk. By calculating the individual fracture risk, the indication for specific osteoporosis treatment can objectively be determined. A consequent specific osteoporosis therapy is required for patients with a high fracture risk and is essential to prevent osteoporotic fractures and their consequences. As first-line therapy a drug with a proven fracture-reducing effect should be taken. However, for successful osteoporosis therapy, many individual factors have to be considered. A personalized treatment approach should be established according to the severity of the disease, the patient’s sex and comorbidities as well as the possible additive and side effects of the drug.

Rund 6 Millionen Menschen sind in Deutschland an Osteoporose erkrankt, überwiegend Frauen nach den Wechseljahren. Aber auch andere Patientengruppen sind betroffen, z. B. bei Langzeit-Einnahme von Glukokortikoiden. Es gibt klare Empfehlungen zur Behandlung der Osteoporose. Der Praktiker sollte diese kennen und darüber hinaus wissen, welche individuellen Faktoren (v. a. Komorbiditäten) neben der Ursache zu berücksichtigen sind.

Schlüsselwörter

Osteoporose - personalisierte Therapie - Bisphosphonate - Denosumab - Teriparatid

Key words

osteoporosis - personalized therapy - bisphosphonates - denosumab - teriparatide
 

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