CC BY-NC-ND 4.0 · Geburtshilfe Frauenheilkd 2019; 79(06): 618-625
DOI: 10.1055/a-0880-9295
GebFra Science
Review/Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Trastuzumab in the Treatment of Pregnant Breast Cancer Patients – an Overview of the Literature

Article in several languages: English | deutsch
Sophia S. Goller
Universitätsklinikum Jena, Klinik für Geburtsmedizin, Placenta-Labor, Jena, Germany
,
Udo R. Markert
Universitätsklinikum Jena, Klinik für Geburtsmedizin, Placenta-Labor, Jena, Germany
,
Karolin Fröhlich
Universitätsklinikum Jena, Klinik für Geburtsmedizin, Placenta-Labor, Jena, Germany
› Author Affiliations
Further Information

Publication History

received 29 July 2018
revised 08 February 2019

accepted 20 March 2019

Publication Date:
14 June 2019 (online)

Abstract

Breast cancer is one of the most common malignancies which appear during pregnancy. Since women are increasingly not giving birth until they are at a more advanced age, it can be assumed that the incidence of pregnancy-related breast cancers will continue to increase in the future. Because of pregnancy-induced changes and conservative diagnosis, these carcinomas are frequently not detected until they are at an advanced stage and thus generally require systemic adjuvant therapy. The available data on optimal chemotherapeutic management are limited. Particularly for the use of the target agent trastuzumab which could crucially contribute to improving the prognosis in the therapy of HER2-overexpressing breast cancer in non-pregnant women, there is a lack of definitive information regarding the profile of action and safety in pregnancy as well as with regard to any long-term effects on the child. Thirty-eight pregnancies on trastuzumab for the treatment of breast cancer were able to be analysed in the literature currently available. Information can be gained from this and conclusions can be drawn which can individualise and decisively improve therapeutic options in the future for the pregnant breast cancer patient.