Z Geburtshilfe Neonatol
DOI: 10.1055/a-0882-7425
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

A Cut-off Value for Gestational Week at Birth for Better Perinatal Outcomes in Early- and Late-Onset Fetal Growth Restriction

Mehmet Sinan Beksac
1  Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey
,
Erdem Fadiloglu
1  Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey
,
Atakan Tanacan
1  Department of Obstetrics and Gynecology, Division of Perinatal Medicine, Hacettepe University, Ankara, Turkey
,
Apostolos Mamopoulos
2  Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
,
Merve Basol
3  Department of Biostatistics, Hacettepe University, Ankara, Turkey
,
Daniel Muresan
4  Department of Obstetrics and Gynecology, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Romania
,
Apostolos Athanasiadis
2  Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece
› Author Affiliations
Further Information

Publication History

received 05 November 2018

accepted 14 March 2019

Publication Date:
17 May 2019 (eFirst)

Abstract

Objective Prediction of cut-off value for gestational week at birth for better perinatal outcomes in early- and late-onset fetal growth restriction (FGR).

Materials and Methods This study consists of 83 singleton pregnancies with FGR that were diagnosed antenatally and confirmed postnatally between January 2017–April 2018. We used the 34th gestational week as a cut-off for early- and late-onset FGR discrimination.

Results Early- and late-onset FGRs were detected in 22 (26.5%) and 61 (73.5%) of the cases, respectively. Expectant management significantly improved birth weight and Apgar scores at the 1st, 5th, and 10th minute in early-onset FGR cases (p=0.001, p=0.019, p=0.002, and p=0.001,respectively). Similar analysis revealed no significant improvements in late-onset FGR (p=0.151, p=0.727, p=0.951 and p=0.477, respectively). Umbilical cord blood gas pH was found to be similar between management modalities in both the early- and late-onset groups (p=0.186 and p=0.456, respectively). Gestational week 33.5 was found to be the threshold for better Apgar scores at the 1st, 5th, and 10th minute according to ROC curve analysis. Percentiles of 4.5, 2.5, and 4.5 were cut-off values for better Apgar scores at the 1st, 5th, and 10th minute, respectively.

Conclusion Expectant management must be the first choice to improve Apgar scores in early-onset FGR cases, and gestational week 33.5 must be considered as a threshold for delivery. Immediate delivery might be the choice in late-onset FGR in necessary cases. However, etiology-based management and perinatal surveillance might also be considered to improve prematurity-related neonatal complications.

Condensed Content