Horm Metab Res 2019; 51(05): 326-329
DOI: 10.1055/a-0885-7169
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Lipid Profiles in Lyme Borreliosis: A Potential Role for Apheresis?

Richard Straube
1  Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany
,
Karin Voit-Bak
1  Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany
,
A. Gor
1  Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany
,
Til Steinmeier
1  Zentrums für Apherese- und Hämofiltration am INUS Tagesklinikum, Cham, Germany
,
George P. Chrousos
2  First Department of Pediatrics, Medical School, Division of Endocrinology, Diabetes and Metabolism, National and Kapodistrian University of Athens, “Aghia Sophia” Children's Hospital, Athens, Greece
,
Bernhard Otto Boehm
3  Lee Kong Chian School of Medicine, NTU Nanyang Technological University, Singapore, Singapore
,
Andreas L. Birkenfeld
4  Department of Medicine III, Section of Metabolic and Vascular Medicine, University Hospital Carl Gustav Carus, Dresden, Germany
5  Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK
6  Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
7  German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
,
Mahmoud Barbir
8  Royal Brompton & Harefield NHS Foundation Trust, Lipoprotein-Apheresis Unit, Cardiology Department, Harefield Hospital, Harefield, Middlesex, UK
,
Wladimir Balanzew
9  Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany
,
Stefan R. Bornstein
3  Lee Kong Chian School of Medicine, NTU Nanyang Technological University, Singapore, Singapore
5  Division of Diabetes & Nutritional Sciences, Faculty of Life Sciences & Medicine, King's College London, London, UK
6  Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany
7  German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
9  Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany
10  Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, University Hospital, Zürich, Switzerland
› Author Affiliations
Further Information

Publication History

received 01 February 2019

accepted 26 March 2019

Publication Date:
09 May 2019 (online)

Abstract

Dyslipidemia and dyslipoproteinemia are common causes of metabolic and cardiovascular diseases. On the other hand, intracellular bacteria, such as Borrelia burgdorferi, utilize host lipids to survive and disseminate within the host. Recent data suggest that elevated lipids are a contributing factor to the maintenance and severity of Lyme disease and its complications. Here we review and discuss the role of lipids in Borreliosis and report on a pilot trial to examine the potential roles of circulating lipids and lipoproteins in patients with Borrelia infection. In this analysis we assessed the clinical and lipid profiles of 519 patients (319 women, 200 men) with a proven history of Lyme disease, before and after an extracorporeal double membrane filtration. Lipid profiles pre- and post-apheresis were analyzed in conjunction with clinical symptoms and parameters of inflammation. Circulating cholesterol, triglycerides, LDL, LP(a), and other inflammatory lipids were significantly reduced after the apheresis, while symptoms of the disorder and bioindexes of inflammation such as CRP improved. Further studies should be initiated to investigate the possibly causal relation between Lyme disease and circulating lipids and to design appropriate therapeutic strategies.