Infektionen in der Schwangerschaft und frühen Kindheit

Zusammenfassung

Die Autoimmunerkrankung Typ-1-Diabetes ist durch einen Verlust der insulinproduzierenden Betazellen im Pankreas charakterisiert. Infektionen könnten potentielle Umweltfaktoren darstellen, die in genetisch prädisponierten Personen einen Autoimmunprozess gegen die Betazellen auslösen und/oder dessen Progression zum klinisch-manifesten Typ-1-Diabetes beschleunigen. Insbesondere für enterovirale Infektionen wurden Assoziationen mit der Entwicklung von Betazell-Autoimmunität und Typ-1-Diabetes nachgewiesen. Effektive Impfstrategien gegen Enteroviren könnten deshalb in Zukunft zur Prävention des Typ-1-Diabetes dienen.

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