Abstract
Background Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage
renal disease (ESRD). Elevated serum concentrations of myeloperoxidase (MPO) are associated
with an increased risk of developing CVD. The objective of this study was to evaluate
serum MPO levels, as well as other laboratory parameters, in individuals with ESRD,
with and without CVD, undergoing hemodialysis.
Methods 80 volunteers were admitted, divided into the following groups: control group (CON):
20 individuals without chronic kidney disease (CKD); ESRD group: 45 individuals with
CKD stage V and ESRD/CVD group: 15 individuals with CKD stage V and with CVD. The
following biomarkers were evaluated: MPO, High sensitivity C-reactive protein (hs-CRP)
and α1-acid glycoprotein, following the manufacturer's guidelines in the package inserts.
The data were processed through the statistical software SPSS 20.0®.
Results The level of MPO for the CON group was 84 ng/mL (73–87 ng/mL), for the ESRD group
77 ng/mL (11–89 ng/mL) and for the ESRD/CVD group 21 ng/mL (8–47 ng/mL), with a significant
statistical difference of the ESRD/CVD group from the CON and ESRD groups (p<0.001).
For the parameters hs-CRP and α1-acid glycoprotein a statistical difference between
the ESRD and ESRD/CVD groups from the CON group (p<0.0001) was observed, but not between
the ESRD and ESRD/CVD groups.
Conclusion It is suggested that further studies should be performed to define the potential
role of MPO as a cardiovascular risk marker for patients with ESRD on hemodialysis.
Key words
cardiovascular disease - myeloperoxidase - α1-acid glycoprotein - C-reactive protein.
