Horm Metab Res 2019; 51(06): 375-380
DOI: 10.1055/a-0896-8853
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Neuroendocrine Control, Inflammation, and Psychological Aspects After Interdisciplinary Therapy in Obese Women

Amanda dos Santos Moraes
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo -UNIFESP – Santos, Sao Paulo, SP, Brazil
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
,
Marcos Alberto Taddeo Cipullo
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
3   Health, Education and Society Department, Federal University of São Paulo – UNIFESP –Santos, São Paulo, SP, Brazil
,
Vanessa Fadanelli Schoenardie Poli
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo -UNIFESP – Santos, Sao Paulo, SP, Brazil
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
,
Renata Astride Rebelo
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
,
Eliane Beraldi Ribeiro
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
4   Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo – UNIFESP – Santos, Sao Paulo, SP, Brazil
,
Lila Missae Oyama
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
4   Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo – UNIFESP – Santos, Sao Paulo, SP, Brazil
,
Stephan Garcia Andrade Silva
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo -UNIFESP – Santos, Sao Paulo, SP, Brazil
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
,
Ana Raimunda Damaso
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
4   Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo – UNIFESP – Santos, Sao Paulo, SP, Brazil
,
Ricardo da Costa Padovani
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
3   Health, Education and Society Department, Federal University of São Paulo – UNIFESP –Santos, São Paulo, SP, Brazil
,
Danielle Arisa Caranti
1   Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo -UNIFESP – Santos, Sao Paulo, SP, Brazil
2   Obesity Study Group (GEO), Federal University of Sao Paulo – UNIFESP – Santos, São Paulo, SP, Brazil
4   Post Graduate Program of Food, Nutrition, Federal University of Sao Paulo – UNIFESP – Santos, Sao Paulo, SP, Brazil
5   Biosciences Department, Federal University of São Paulo – UNIFESP –Santos, São Paulo, SP, Brazil
› Author Affiliations
Further Information

Publication History

received 06 November 2018

accepted 08 April 2019

Publication Date:
17 June 2019 (online)

Abstract

Obesity is a chronic and multifactorial disease promoted by positive energy balance. The objective was to evaluate the effects of interdisciplinary therapy in the neuroendocrine control of food intake, inflammatory markers, and psychological aspects in obese women. Forty-seven obese women (43.32±5.82 years, 34.86±3.08 kg/m2), aged 30–50 years, participated in an interdisciplinary lifestyle change therapy, consisting of nutritional counseling, physical exercises, and psychological therapy for 36 weeks. After the long-term therapy, there was a decrease in body weight (Δ –5.36 kg), BMI (Δ –2.01 kg/m2), abdominal (Δ –9.09 cm), hip (Δ –5.03 cm), and thigh (Δ –5.07 cm) perimeters. There was also a significant improvement in body composition, with an increase in fat-free mass (Δ 1.60%) and reduction of body fat (Δ –3.74 kg). The therapy proposed also provided an improvement in depression scores (Δ –6.63), anxiety (Δ –4.07), body image (Δ –25.25), and binge eating (Δ –5.25). There was a significant reduction in serum levels of leptin (Δ –15.62 ng/ml). The interdisciplinary therapy was able to provide both, physical and psychological benefits in energy balance, which enables the use of this model as a feasible clinical strategy for the treatment of obesity.

Supplementary Material