The Effect of High-Intensity Interval Training on Physical Parameters, Metabolomic Indexes and Serum Ficolin-3 Levels in Patients with Prediabetes and Type 2 Diabetes

Abstract

Background Exercise benefits people with abnormal glucose metabolism, and serum ficolin-3 levels have been reported to be associated with diabetes. However, no relevant study has discussed the relationship between high-intensity interval training (HIIT) and ficolin-3 in a Chinese population.

Objective To compare the effect of HIIT and moderate-intensity continuous training (MICT) on blood pressure, glucose control, the lipid profile and the serum ficolin-3 level in patients with prediabetes and type 2 diabetes (T2D).

Methods We recruited 145 patients with prediabetes and 196 T2D patients from March to June 2018. All participants were randomly grouped into HIIT and MICT groups. HIIT consisted of progressing to twelve 1-min bouts at 90% maximal aerobic capacity (1 min recovery), and MICT consisted of progressing to 20 min at 65% maximal aerobic capacity. ˙VO₂peak, body composition, blood pressure, glucose, the lipid profile and the serum ficolin-3 level were measured before and after three weeks of training.

Results After 3 weeks of training, participants in both the HIIT and MICT groups had significantly lower SBP, BMI, waist circumference, % body fat, and serum levels of FPG, TC, TGs, UA and ficolin-3, as well as increased vital capacity and VOmax. Additionally, the patients in the HIIT group still had significantly lower levels of 2hPG and LDL-C, regardless of prediabetes or diabetes status. After comparing the differences in the variation in parameters between the HIIT and MICT groups, we found that HIIT could help patients with prediabetes or diabetes acquire better effects of treatment in regard to anthropometry, blood pressure, glucose control, UA and ficolin-3 levels than MICT. Finally, the patients in the HIIT group had a lower rate of loss to follow-up and a higher rate of session attendance.

Conclusions Both HIIT and MICT were beneficial exercise strategies for health in patients with prediabetes or T2D. However, HIIT is a more time-efficient strategy and could lower the serum level of ficolin-3 in patients after 3 weeks of training.

Key words

HIIT - MICT - ficolin-3 - prediabetes - type 2 diabetes

Publication History

Received: 23 July 2019
Received: 23 September 2019

Accepted: 14 October 2019

Article published online:
13 January 2020

• References

• 1 Adams KF, Schatzkin A, Harris TB. et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50–71 years old. The New England Journal of Medicine 2006; 355: 763-778 DOI: 10.1056/NEJMoa055643.
• 2 Yang W, Lu J, Weng J. et al. Prevalence of diabetes among men and women in China. The New England Journal of Medicine 2010; 362: 1090-1101 DOI: 10.1056/NEJMoa0908292.
• 3 Tabak AG, Herder C, Rathmann W. et al. Prediabetes: A high-risk state for diabetes development. Lancet 2012; 379: 2279-2290 DOI: 10.1016/S0140-6736(12)60283-9.
• 4 Maser RE, Lenhard MJ. Cardiovascular autonomic neuropathy due to diabetes mellitus: Clinical manifestations, consequences, and treatment. The Journal of Clinical Endocrinology and Metabolism 2005; 90: 5896-5903 DOI: 10.1210/jc.2005-0754.
• 5 Salvotelli L, Stoico V, Perrone F. et al. Prevalence of neuropathy in type 2 diabetic patients and its association with other diabetes complications: The verona diabetic foot screening program. Journal of Diabetes and its Complications 2015; 29: 1066-1070 DOI: 10.1016/j.jdiacomp.2015.06.014.
• 6 Colley RC, Garriguet D, Janssen I. et al. Physical activity of Canadian adults: Accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health Reports 2011; 22: 7-14
• 7 Colberg SR, Sigal RJ, Fernhall B. et al. Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: Joint position statement. Diabetes Care 2010; 33: e147-e167 DOI: 10.2337/dc10-9990.
• 8 Colberg SR, Sigal RJ, Yardley JE. et al. Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care 2016; 39: 2065-2079 DOI: 10.2337/dc16-1728.
• 9 Knowler WC, Barrett-Connor E, Fowler SE. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine 2002; 346: 393-403 DOI: 10.1056/NEJMoa012512.
• 10 Blomster JI, Chow CK, Zoungas S. et al. The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus. Diabetes, Obesity & Metabolism 2013; 15: 1008-1012 DOI: 10.1111/dom.12122.
• 11 Dixit S, Maiya AG, Shastry BA. Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: A single blind, parallel group randomized controlled trial. Journal of Diabetes and its Complications 2014; 28: 332-339 DOI: 10.1016/j.jdiacomp.2013.12.006.
• 12 Troiano RP, Berrigan D, Dodd KW. et al. Physical activity in the United States measured by accelerometer. Medicine and Science in Sports and Exercise 2008; 40: 181-188 DOI: 10.1249/mss.0b013e31815a51b3.
• 13 Colley RC, Garriguet D, Janssen I. et al. Physical activity of Canadian children and youth: Accelerometer results from the 2007 to 2009 Canadian Health Measures Survey. Health Reports 2011; 22: 15-23
• 14 Sanudo B, Munoz T, Davison GW. et al. High-intensity interval training combined with vibration and dietary restriction improves body composition and blood lipids in obese adults: A randomized trial. Dose-response : A publication of International Hormesis Society 2018; 16: 1559325818797015 DOI: 10.1177/1559325818797015.
• 15 Smith-Ryan AE, Trexler ET, Wingfield HL. et al. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women. Journal of Sports Sciences 2016; 34: 2038-2046 DOI: 10.1080/02640414.2016.1149609.
• 16 Hein E, Honore C, Skjoedt MO. et al. Functional analysis of Ficolin-3 mediated complement activation. PloS One 2010; 5: e15443 DOI: 10.1371/journal.pone.0015443.
• 17 Zhang X, Hu Y, Shen J. et al. Low levels of ficolin-3 are associated with diabetic peripheral neuropathy. Acta Diabetologica 2016; 53: 295-302 DOI: 10.1007/s00592-015-0780-6.
• 18 Zheng B, Li T, Chen H. et al. Correlation between ficolin-3 and vascular endothelial growth factor-to-pigment epithelium-derived factor ratio in the vitreous of eyes with proliferative diabetic retinopathy. American Journal of Ophthalmology 2011; 152: 1039-1043 DOI: 10.1016/j.ajo.2011.05.022.
• 19 American Diabetes A. Standards of medical care in diabetes–2012. Diabetes Care 2012; 35: S11-S63 DOI: 10.2337/dc12-s011.
• 20 Unger RH. Glucagon physiology and pathophysiology. The New England Journal of Medicine 1971; 285: 443-449 DOI: 10.1056/NEJM197108192850806.
• 21 Tuomilehto J, Lindstrom J, Eriksson JG. et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. The New England Journal of Medicine 2001; 344: 1343-1350 DOI: 10.1056/NEJM200105033441801.
• 22 Lindstrom J, Louheranta A, Mannelin M. et al. The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care 2003; 26: 3230-3236
• 23 American Diabetes A. Standards of medical care in diabetes–2013. Diabetes Care 2013; 36: S11-S66 DOI: 10.2337/dc13-S011.
• 24 Duncan GE, Anton SD, Sydeman SJ. et al. Prescribing exercise at varied levels of intensity and frequency: A randomized trial. Archives of Internal Medicine 2005; 165: 2362-2369 DOI: 10.1001/archinte.165.20.2362.
• 25 Phillips BE, Kelly BM, Lilja M. et al. A Practical and time-efficient high-intensity interval training program modifies cardio-metabolic risk factors in adults with risk factors for type II diabetes. Frontiers in Endocrinology 2017; 8: 229 DOI: 10.3389/fendo.2017.00229.
• 26 McAuley PA, Artero EG, Sui X. et al. The obesity paradox, cardiorespiratory fitness, and coronary heart disease. Mayo Clinic Proceedings 2012; 87: 443-451 DOI: 10.1016/j.mayocp.2012.01.013.
• 27 Gibala MJ, Little JP, Macdonald MJ. et al. Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology 2012; 590: 1077-1084 DOI: 10.1113/jphysiol.2011.224725.
• 28 Jung ME, Bourne JE, Beauchamp MR. et al. High-intensity interval training as an efficacious alternative to moderate-intensity continuous training for adults with prediabetes. Journal of diabetes research 2015; 2015: 191595 DOI: 10.1155/2015/191595.
• 29 Madsen SM, Thorup AC, Overgaard K. et al. High intensity interval training improves glycaemic control and pancreatic beta cell function of type 2 diabetes patients. PloS One 2015; 10: e0133286 DOI: 10.1371/journal.pone.0133286.
• 30 Kong Z, Fan X, Sun S. et al. Comparison of high-intensity interval training and moderate-to-vigorous continuous training for cardiometabolic health and exercise enjoyment in obese young women: a randomized controlled trial. PloS One 2016; 11: e0158589 DOI: 10.1371/journal.pone.0158589.
• 31 Matsushita M. Ficolins: Complement-activating lectins involved in innate immunity. Journal of Innate Immunity 2010; 2: 24-32 DOI: 10.1159/000228160.
• 32 Yuan XS, Shi H, Wang HY. et al. Ficolin-3/adiponectin ratio for the prediction of gestational diabetes mellitus in pregnant women. Journal of Diabetes Investigation 2018; 9: 403-410 DOI: 10.1111/jdi.12688.
• 33 Chen H, Lu J, Chen X. et al. Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes. Journal of Molecular Cell Biology 2012; 4: 256-257 DOI: 10.1093/jmcb/mjs032.
• 34 Yuan XS, Zhang M, Wang HY. et al. Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women. Endocrine Journal 2018; 65: 499-508 DOI: 10.1507/endocrj.EJ17-0508.