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Pharmacopsychiatry 2023; 56(03): 108-117
DOI: 10.1055/a-1027-7055
Review

Circadian Clocks in the Regulation of Neurotransmitter Systems

Jana-Thabea Kiehn
1   Institute of Neurobiology, University of Lübeck, Lübeck, Germany
,
Frank Faltraco
2   Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Denise Palm
2   Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Johannes Thome
2   Department of Psychiatry and Psychotherapy, University of Rostock, Rostock, Germany
,
Henrik Oster
1   Institute of Neurobiology, University of Lübeck, Lübeck, Germany
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Abstract

To anticipate and adapt to daily recurring events defined by the earth’s rotation such as light-dark and temperature cycles, most species have developed internal, so-called circadian clocks. These clocks are involved in the regulation of behaviors such as the sleep-wake cycle and the secretion of hormones and neurotransmitters. Disruptions of the circadian system affect cognitive functions and are associated with various diseases that are characterized by altered neurotransmitter signaling. In this review, we summarize the current knowledge about the interplay of the circadian clock and the regulation of psychiatric health and disease.

Key words

circadian clocks - clock genes - neurotransmitter - psychiatric disorders - attention-deficit hyperactivity disorder (ADHS)


Publication History

Received: 21 December 2018
Received: 28 August 2019

Accepted: 08 October 2019

Article published online:
30 October 2019

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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