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Exp Clin Endocrinol Diabetes 2020; 128(06/07): 469-472
DOI: 10.1055/a-1083-6272
DOI: 10.1055/a-1083-6272
Mini-Review
Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses
Funding This work was performed in the framework of the DFG priority programme SPP1629 and supported by DFG grants FU356/7–1 and 7–2 to DF.
Abstract
Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on systemic versus organ-specific TH action and discuss their wider implication for clinical care.
Publication History
Received: 01 September 2019
Received: 25 November 2019
Accepted: 12 December 2019
Article published online:
13 January 2020
© Georg Thieme Verlag KG
Stuttgart · New York
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