Horm Metab Res
DOI: 10.1055/a-1111-9249
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Serum Irisin Concentrations in Severely Inflamed Patients

1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Davide Corleo
1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Sonya Vasto
3  Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, Palermo, Italy
,
Carola Buscemi
1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Anna Maria Barile
1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Giuseppe Rosafio
1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Cristiana Randazzo
1  Dipartimento di Promozione della Salute, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
2  Unit of Malattie Endocrine, del Ricambio e della Nutrizione, University of Palermo, Palermo, Italy
,
Walter Currenti
4  Dipartimento of Scienze Biomediche e Biotecnologiche, University of Catania, Catania, Italy
,
Fabio Galvano
4  Dipartimento of Scienze Biomediche e Biotecnologiche, University of Catania, Catania, Italy
› Author Affiliations
Further Information

Publication History

received 06 January 2020

accepted 28 January 2020

Publication Date:
20 February 2020 (online)

Abstract

Irisin is a recently discovered exercise-induced myokine that has been attributed the role of favoring white-to-brown adipose tissue trans-differentiation. We confirmed in a population-based cohort that irisin serum concentrations are independently correlated with the habitual level of physical activity, but we also observed an independent correlation with serum concentrations of high-sensitivity C-reactive protein (hs-CRP), thus suggesting that inflammation may influence irisin production. In order to investigate the association between irisin and inflammation, we measured serum irisin concentrations in a group of inflamed inpatients. We hypothesized that if an association between irisin and inflammation exists, severely inflamed patients, even though physically inactive, might also exhibit high serum irisin levels. We recruited 40 consecutive markedly inflamed inpatients on the basis of serum CRP levels. Their irisin serum concentrations (Phoenix Europe, Germany) were compared with those obtained in the population-based cohort of the ABCD_2 study (Alimentazione, Benessere Cardiovascolare e Diabete) (ISRCTN15840340). The inflamed patients exhibited higher serum irisin concentrations (median: 6.77 ng/ml; 95% CI for the median: 5.97–7.23) than those observed in the ABCD cohort (median: 5.21 ng/ml; 95% CI for the median: 5.08–5.30; p <0.001). Irisin concentrations were significantly correlated with age (r=−0.44; p <0.001), creatinine (r=−0.35; p <0.05), and fibrinogen (r=0.40; p <0.05) concentrations. No association was observed between irisin, interleukine-6 and tumor necrosis factor alpha. This study confirms the association between inflammation and irisin concentrations. Further studies are needed to understand the mechanisms underlying this association and its possible clinical implications.