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Horm Metab Res 2020; 52(06): 412-420
DOI: 10.1055/a-1119-1063
Review

Role of Mast Cells in the Control of Aldosterone Secretion

Antoine-Guy Lopez‡
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
2   Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France
,
Céline Duparc‡
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
,
Alexandre Naccache
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
3   Department of Pediatrics, Rouen University Hospital, Rouen, France
,
Mireille Castanet
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
3   Department of Pediatrics, Rouen University Hospital, Rouen, France
,
Hervé Lefebvre   §
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
2   Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital, Rouen, France
,
Estelle Louiset   §
1   Normandie University, UNIROUEN, INSERM, DC2N, Rouen, France
› Author Affiliations Funding Information: This work was supported by the Institut National de la Santé et de la Recherche Médicale, the Conseil Régional de Normandie and the European Regional Development Fund program Steroids.
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Abstract

Mast cells are immune cells present in adrenals from various species. Proliferation and activation of adrenal mast cells seem to be influenced by environment, since they increase during summer and in response to sodium restriction in frogs and mouse, respectively. Although the physiological factors regulating adrenal mast cell activity have not been identified, they might involve neurotransmitters and the renin-angiotensin system. Some data indicate that adrenal mast cells stimulate proliferation of steroidogenic cells in the zona glomerulosa and activate the mineralocorticoid production. In human, mast cell degranulation stimulates aldosterone synthesis through the release of serotonin (5-HT) and activation of 5-HT4 receptors. Increase in mast cell population and upregulation of the 5-HT signaling pathway occur in aldosterone-producing adenomas. In particular, aldosterone-producing adenoma cells overexpress 5-HT4 receptors and are hyper-responsive to 5-HT4 receptor agonists. These data suggest that the intra-adrenal serotonergic regulatory system represents a potential target for development of both adrenal imaging methods to evaluate the lateralization of aldosterone production, and pharmacological treatments of primary aldosteronism.

Key words

adrenal cortex - aldosterone - aldosterone-producing adenoma - mast cells - serotonin

§ H.L. and E.L. share senior authorship




Publication History

Received: 20 December 2019

Accepted: 05 February 2020

Article published online:
25 March 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 

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