Horm Metab Res 2020; 52(05): 316-321
DOI: 10.1055/a-1128-6957
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

The Remission Rate of Type 2 Diabetes Outpatients with Premixed Insulin: The Result of a 5-Year Prospective Study

Fu-peng Liu
1   Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China
,
Ming-hui Sun
2   Division of Endocrinology, Department of Internal Medicine, Liaocheng People’s Hospital, Liaocheng, China
,
Jun-yu Zhao
3   Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China
4   Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China
,
Ming Yang
5   Department of Internal Medicine, Peking University People’s Hospital, Peking, China
,
Xiao-jun Zhou
3   Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China
4   Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China
,
Zhong-wen Zhang
3   Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China
4   Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China
,
Jian-jun Dong
6   Division of Endocrinology, Department of Medicine, Qilu Hospital of Jinan, Jinan, China
,
Lin Liao
3   Division of Endocrinology, Department of Internal Medicine, the First Affiliated Hospital of Shandong First Medical University, Jinan, China
4   Division of Endocrinology, Department of Internal Medicine, Shandong Provincial, Qianfoshan Hospital, Shandong University, Jinan, China
› Author Affiliations
Funding Chinese Scholarship Council: 201509370027; Grant for the Development of Science and Technology of Jinan City: 201602172; National Natural Science Foundation of China Grants: 81670757, 81570742.
Further Information

Publication History

received 22 February 2020

accepted 27 February 2020

Publication Date:
13 May 2020 (online)

Abstract

The aim of the study was to evaluate the remission rate with short-term premixed insulin therapy in newly diagnosed type 2 diabetes outpatients and investigate predictors contributing to the remission rate. A 5-year prospective study was conducted with a total of 170 patients enrolled. Patients were treated with premixed insulin monotherapy or insulin in combination with one or two oral drugs. After glucose levels were well controlled, insulin and oral drugs were discontinued in a stepwise manner. The prolonged and partial remission rates were calculated and the possible factors contributing to remission were also analyzed. A total of 164 subjects completed the research study. The prolonged remission, partial remission and non-remission rates at the 5-year follow-up were 9.8, 59.8, and 30.5%, respectively. The remission rate was negatively correlated with disease duration (r=0.39). The combined rate of remission (prolonged and partial remission) significantly decreased when the duration was longer than 16 days, and reduced to approximately 50% after 1 month. Moreover, 75% of prolonged remission patients had duration of < 16 days. At the 5-year follow-up, the prolonged remission rate was 9.8% and the partial remission rate was 59.8%. Furthermore, the duration after diagnosis is an independent predictor of remission rate, and initiation of short-term premixed insulin therapy within the first 16 days of diabetes diagnosis is very important for remission. This is the first study to evaluate the remission rate associated with short-term premixed insulin therapy in recently diagnosed type 2 diabetes outpatients. At the 5-year follow-up, the prolonged remission rate was 9.8% and the partial remission rate was 59.8%. The duration of diabetes was identified as an independent predictor of drug-free remission. The initiation of short-term premixed insulin therapy within 15 days of diabetes onset is particular importance for remission.

 
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