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DOI: 10.1055/a-1134-2968
Das Gorham-Stout-Syndrom – eine diagnostische und therapeutische Herausforderung
Gorham-Stout Syndrome – a diagnostic and therapeutic challenge![](https://www.thieme-connect.de/media/10.1055-s-00034914/202002/lookinside/thumbnails/10.1055a-1134-2968-1.jpg)
Zusammenfassung
Das Gorham-Stout-Syndrom (GSS) beschreibt ein pathophysiologisch idiopathisches Krankheitsbild, welches mit Osteolysen und Proliferationen von Blut- und Lymphgefäßen assoziiert wird. In der Literatur sind nur rund 300 Fälle dieses seltenen mono- oder polyostostischen Krankheitsbildes beschrieben. In diesem Beitrag präsentieren wir zwei Patienten, die am GSS erkrankt sind. Ihre jeweilige Krankheitsgeschichte mit einer deutlich verzögerten Diagnosestellung, limitierten Behandlungsoptionen sowie unerwünschten Nebenwirkungen im Rahmen der medikamentösen Therapie verdeutlicht die Komplexität von Diagnostik und Behandlung des GSS.
Abstract
Gorham-Stout syndrome (GSS) describes a pathophysiological idiopathic entity associated with osteolytic lesions and proliferation of blood- and lymph vessels. There are only around 300 reported cases of this rare, mono- or polyostostic condition in literature. This article presents the cases of two patients with GSS. Their respective medical histories with a delayed diagnosis of the disease, limited treatment options as well as treatment side-effects emphasise the complexity of diagnosis and treatment in GSS.
Schlüsselwörter
Gorham-Stout-Syndrom - medikamentöse Therapie - Bisphosphonate - Chylothorax - NebenwirkungenKey words
Gorham-Stout Syndrom - vanishing bone disease - medical treatment - bisphosphonates - chylothorax - treatment side-effectsPublication History
Received: 09 March 2020
Accepted: 12 March 2020
Article published online:
02 June 2020
© Georg Thieme Verlag KG
Stuttgart · New York
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