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Horm Metab Res 2020; 52(05): 280-288
DOI: 10.1055/a-1142-8815
Review
© Georg Thieme Verlag KG Stuttgart · New York

Research Progress on lncRNA Functions and Mechanisms in Pituitary Adenomas

Qiu Du 
1   Department of Neurosurgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China
2   Central Laboratory, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China
,
De-shan Yao
3   Department of Cardiology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China
,
You-wei Wang
1   Department of Neurosurgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China
,
Cheng Cheng
1   Department of Neurosurgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China
› Author Affiliations Funding: National Natural Science Foundation of China; Grant No. 81702479.
Further Information

Publication History

received 31 July 2019

accepted 10 March 2020

Publication Date:
13 May 2020 (online)

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Abstract

Despite being the most common human neuroendocrine tumor, the pathogenesis of pituitary adenomas (PAs) is still unclear. Long non-coding RNA (lncRNA) is involved in a variety of physiological and pathological processes, and has been shown to play a key role in the process of tumor instigation and development by affecting the proliferation, migration, invasiveness, and metastasis of tumor cells. Therefore, lncRNAs may be used as diagnostic and prognostic markers of tumors. In this paper, the effect of lncRNA on the onset and progression of PAs is reviewed so as to provide a profound understanding of its pathogenesis and clinical reference for the early diagnosis of PAs.

Key words

pituitary adenomas - long non-coding RNA - mechanism of action - biological function
 

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