Intraventrikuläre Blutungen

Stefan Wolf; Dimitre Staykov

doi:10.1055/a-1166-0632

Intensivmedizin up2date, Table of Contents

Intensivmedizin up2date 2020; 16(04): 419-431
DOI: 10.1055/a-1166-0632

Neuro-Intensivmedizin

Intraventrikuläre Blutungen

Stefan Wolf

,

Dimitre Staykov

Abstract

All articles of this category

Die Ventrikelblutung ist eine häufige Komplikation sowohl der intrazerebralen als auch der subarachnoidalen Blutung und führt zu einer deutlichen Erhöhung der Morbidität und Mortalität dieser Erkrankungen. Die in den letzten Jahren erweiterte Kenntnis der zugrunde liegenden Pathomechanismen der Ventrikelblutung hat zur Entwicklung spezifischer Therapieansätze beigetragen. Dieser Artikel stellt sie vor.

Schlüsselwörter

Ventrikelblutung - Gehirnblutung - Hydrozephalus - Hirndruck - Ventrikeltamponade

Full Text

References

Literatur
1 Andrews CO, Engelhard HH. Fibrinolytic therapy in intraventricular hemorrhage. Ann Pharmacother 2001; 35: 1435-1448
2 Maas MB, Nemeth AJ, Rosenberg NF. et al. Delayed intraventricular hemorrhage is common and worsens outcomes in intracerebral hemorrhage. Neurology 2013; 80: 1295-1299 doi:10.1212/WNL.0b013e31828ab2a7
3 Kim BJ, Lee SH, Ryu WS. et al. Extents of white matter lesions and increased intraventricular extension of intracerebral hemorrhage. Crit Care Med 2013; 41: 1325-1331 doi:10.1097/CCM.0b013e31827c05e9
4 Diringer MN, Edwards DF, Zazulia AR. Hydrocephalus: a previously unrecognized predictor of poor outcome from supratentorial intracerebral hemorrhage. Stroke 1998; 29: 1352-1357
5 Graeb DA, Robertson WD, Lapointe JS. et al. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology 1982; 143: 91-96
6 Staykov D, Schwab S. Clearing bloody cerebrospinal fluid: clot lysis, neuroendoscopy and lumbar drainage. Curr Opin Crit Care 2013; 19: 92-100 doi:10.1097/MCC.0b013e32835cae5e
7 Claassen J, Bernardini GL, Kreiter K. et al. Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage: the Fisher scale revisited. Stroke 2001; 32: 2012-2020 doi:10.1161/hs0901.095677
8 Kiphuth IC, Huttner HB, Breuer L. et al. Vasospasm in Intracerebral Hemorrhage with Ventricular Involvement: A Prospective Pilot Transcranial Doppler Sonography Study. Cerebrovasc Dis 2011; 32: 420-425 doi:10.1159/000330652
9 Regula JU, Schill J, Ringleb PA. et al. Cerebral vasospasm and delayed cerebral ischemia in intraventricular hemorrhage. Neurocrit Care 2014; 20: 460-465 doi:10.1007/s12028-013-9897-z
10 Lozier AP, Sciacca RR, Romagnoli MF. et al. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 2002; 51: 170-181 discussion 181–182
11 Naff N, Williams MA, Keyl PM. et al. Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial. Stroke 2011; 42: 3009-3016 doi:10.1161/STROKEAHA.110.610949
12 Hanley DF, Lane K, McBee N. et al. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet 2017; 389: 603-611 doi:10.1016/s0140-6736(16)32410-2
13 Staykov D, Huttner HB, Lunkenheimer J. et al. Single versus bilateral external ventricular drainage for intraventricular fibrinolysis in severe ventricular haemorrhage. J Neurol Neurosurg Psychiatry 2010; 81: 105-108 doi:10.1136/jnnp.2008.168427
14 Hinson HE, Melnychuk E, Muschelli J. et al. Drainage efficiency with dual versus single catheters in severe intraventricular hemorrhage. Neurocrit Care 2012; 16: 399-405 doi:10.1007/s12028-011-9569-9
15 Staykov D, Bardutzky J, Huttner HB. et al. Intraventricular fibrinolysis for intracerebral hemorrhage with severe ventricular involvement. Neurocrit Care 2011; 15: 194-209 doi:10.1007/s12028-010-9390-x
16 Ziai WC, Muschelli J, Thompson CB. et al. Factors affecting clot lysis rates in patients with spontaneous intraventricular hemorrhage. Stroke 2012; 43: 1234-1239 doi:10.1161/STROKEAHA.111.641050
17 Staykov D, Wagner I, Volbers B. et al. Dose effect of intraventricular fibrinolysis in ventricular hemorrhage. Stroke 2011; 42: 2061-2064 doi:10.1161/STROKEAHA.110.608190
18 Webb AJ, Ullman NL, Mann S. et al. Resolution of Intraventricular Hemorrhage Varies by Ventricular Region and Dose of Intraventricular Thrombolytic: The Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) Program. Stroke 2012; 43: 1666-1668 doi:10.1161/STROKEAHA.112.650523
19 Morgan T, Awad I, Keyl P. et al. Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial. Acta Neurochir Suppl 2008; 105: 217-220
20 Jaffe J, Melnychuk E, Muschelli J. et al. Ventricular catheter location and the clearance of intraventricular hemorrhage. Neurosurgery 2012; 70: 1258-1263 discussion 1263–1264 doi:10.1227/NEU.0b013e31823f6571
21 Jackson DA, Patel AV, Darracott RM. et al. Safety of intraventricular hemorrhage (IVH) thrombolysis based on CT localization of external ventricular drain (EVD) fenestrations and analysis of EVD tract hemorrhage. Neurocrit Care 2013; 19: 103-110 doi:10.1007/s12028-012-9713-1
22 Dey M, Stadnik A, Riad F. et al. Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial. Neurosurgery 2015; 76: 291-300 discussion 301 doi:10.1227/neu.0000000000000624
23 Fam MD, Stadnik A, Zeineddine HA. et al. Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis. Neurosurgery 2018; 83: 1260-1268 doi:10.1093/neuros/nyx587
24 Volbers B, Wagner I, Willfarth W. et al. Intraventricular fibrinolysis does not increase perihemorrhagic edema after intracerebral hemorrhage. Stroke 2013; 44: 362-366 doi:10.1161/STROKEAHA.112.673228
25 Fam MD, Zeineddine HA, Eliyas JK. et al. CSF inflammatory response after intraventricular hemorrhage. Neurology 2017; 89: 1553-1560 doi:10.1212/wnl.0000000000004493
26 Li Y, Zhang H, Wang X. et al. Neuroendoscopic Surgery versus External Ventricular Drainage Alone or with Intraventricular Fibrinolysis for Intraventricular Hemorrhage Secondary to Spontaneous Supratentorial Hemorrhage: A Systematic Review and Meta-Analysis. PLoS One 2013; 8: e80599 doi:10.1371/journal.pone.0080599
27 Klimo P, Kestle JR, MacDonald JD. et al. Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage. J Neurosurg 2004; 100: 215-224
28 Kwon OY, Kim YJ, Cho CS. et al. The Utility and Benefits of External Lumbar CSF Drainage after Endovascular Coiling on Aneurysmal Subarachnoid Hemorrhage. J Korean Neurosurg Soc 2008; 43: 281-287 doi:10.3340/jkns.2008.43.6.281
29 Widenka DC, Wolf S, Schürer L. et al. Factors leading to hydrocephalus after aneurysmal subarachnoid hemorrhage. Neurol Neurochir Pol 2000; 34: 56-60
30 Qian C, Yu X, Chen J. et al. Effect of the drainage of cerebrospinal fluid in patients with aneurismal subarachnoid hemorrhage: A meta-analysis. Medicine 2016; 95: e5140 doi:10.1097/md.0000000000005140
31 Al-Tamimi YZ, Bhargava D, Feltbower RG. et al. Lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: a prospective, randomized, controlled trial (LUMAS). Stroke 2012; 43: 677-682 doi:10.1161/STROKEAHA.111.625731
32 Park S, Yang N, Seo E. The effectiveness of lumbar cerebrospinal fluid drainage to reduce the cerebral vasospasm after surgical clipping for aneurysmal subarachnoid hemorrhage. J Korean Neurosurg Soc 2015; 57: 167-173 doi:10.3340/jkns.2015.57.3.167
33 Borkar SA, Singh M, Kale SS. et al. Spinal Cerebrospinal Fluid Drainage for prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized controlled study. Asian J Neurosurg 2018; 13: 238-246 doi:10.4103/1793-5482.228512
34 Bardutzky J, Witsch J, Juttler E. et al. EARLYDRAIN – outcome after early lumbar CSF-drainage in aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial. Trials 2011; 12: 203 doi:10.1186/1745-6215-12-203
35 Huttner HB, Nagel S, Tognoni E. et al. Intracerebral hemorrhage with severe ventricular involvement: lumbar drainage for communicating hydrocephalus. Stroke 2007; 38: 183-187
36 Huttner HB, Schwab S, Bardutzky J. Lumbar drainage for communicating hydrocephalus after ICH with ventricular hemorrhage. Neurocrit Care 2006; 5: 193-196
37 Staykov D, Huttner HB, Struffert T. et al. Intraventricular fibrinolysis and lumbar drainage for ventricular hemorrhage. Stroke 2009; 40: 3275-3280 doi:10.1161/STROKEAHA.109.551945
38 Speck V, Staykov D, Huttner HB. et al. Lumbar catheter for monitoring of intracranial pressure in patients with post-hemorrhagic communicating hydrocephalus. Neurocrit Care 2010; 14: 208-215 doi:10.1007/s12028-010-9459-6
39 Staykov D, Speck V, Volbers B. et al. Early recognition of lumbar overdrainage by lumboventricular pressure gradient. Neurosurgery 2011; 68: 1187-1191 discussion 1191 doi:10.1227/NEU.0b013e31820c0274
40 Zhang Z, Li X, Liu Y. et al. Application of neuroendoscopy in the treatment of intraventricular hemorrhage. Cerebrovasc Dis 2007; 24: 91-96 doi:10.1159/000103122
41 Staykov D, Kuramatsu JB, Bardutzky J. et al. Efficacy and safety of combined intraventricular fibrinolysis with lumbar drainage for prevention of permanent shunt dependency after intracerebral hemorrhage with severe ventricular involvement: A randomized trial and individual patient data meta-analysis. Ann Neurol 2017; 81: 93-103 doi:10.1002/ana.24834