Rheumatologische paraneoplastische Syndrome

Zusammenfassung

Rheumatologische paraneoplastische Syndrome sind selten, stellten jedoch eine wichtige Differenzialdiagnose zu klassischen rheumatologischen Krankheitsbildern dar. Durch das Erkennen der eindrücklichen Syndrome mit typischen Labor- und Untersuchungsbefunden ist oftmals eine beschleunigte Diagnose der zugrundeliegenden Malignität und kurative Therapie möglich. In dieser Übersichtsarbeit werden die Charakteristika rheumatologischer paraneoplastischer Syndrome vorgestellt.

Abstract

Paraneoplastic syndromes in Rheumatology are rare, but they represent an important differential diagnosis to classic rheumatic and musculoskeletal diseases. The recognition of their typical laboratory and clinical examination findings often allows an accelerated diagnosis of the underlying malignancy and curative therapy. This review presents the characteristics of paraneoplastic syndromes in rheumatology

Schlüsselwörter

Malignom - Rheumatologie - Paraneoplasie - Myositis - Tumorsuche

Key words

Malignancy - Rheumatology - Paraneoplasia - Myositis - Tumorsuche

• Literatur

• 1 Albayda J, Pinal-Fernandez I, Huang W. et al. Antinuclear Matrix Protein 2 Autoantibodies and Edema, Muscle Disease, and Malignancy Risk in Dermatomyositis Patients. Arthritis care & research 2017; 69: 1771-1776
• 2 Baijens LWJ, Manni JJ. Paraneoplastic syndromes in patients with primary malignancies of the head and neck. Four cases and a review of the literature. European Archives of Oto-Rhino-Laryngology and Head & Neck 2006; 263: 32-36
• 3 Cohen JD, Li L, Wang Y. et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018; 359: 926
• 4 De Hollanda A, Beucher A, Henrion D. et al. Systemic and immune manifestations in myelodysplasia: A multicenter retrospective study. Arthritis care & research 2011; 63: 1188-1194
• 5 Dutton K, Soden M. Malignancy screening in autoimmune myositis among Australian rheumatologists. Internal Medicine Journal 2017; 47: 1367-1375
• 6 Ehrenstein B, Pongratz G, Fleck M. et al. The ability of rheumatologists blinded to prior workup to diagnose rheumatoid arthritis only by clinical assessment: a cross-sectional study. Rheumatology (Oxford) 2018; 57: 1592-1601
• 7 Fain O, Hamidou M, Cacoub P. et al. Vasculitides associated with malignancies: Analysis of sixty patients. Arthritis care & research 2007; 57: 1473-1480
• 8 Greer JM, Longley S, Edwards NL. et al. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine (Baltimore) 1988; 67: 220-230
• 9 Hautmann AH, Hautmann MG, Kölbl O. et al. Tumor-Induced Osteomalacia: an Up-to-Date Review. Curr Rheumatol Rep 2015; 17: 37
• 10 Irving G, Neves AL, Dambha-Miller H. et al. International variations in primary care physician consultation time: a systematic review of 67 countries. BMJ Open 2017; 7: e017902
• 11 Izumi M, Takayama K, Yabuuchi H. et al. Incidence of hypertrophic pulmonary osteoarthropathy associated with primary lung cancer. Respirology 2010; 15: 809-812
• 12 Jiang Y, Xia W-B, Xing X-P. et al. Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. Journal of Bone and Mineral Research 2012; 27: 1967-1975
• 13 Kisacik B, Onat AM, Kasifoglu T. et al. Diagnostic dilemma of paraneoplastic arthritis: Case series. International Journal of Rheumatic Diseases 2014; 17: 640-645
• 14 Leatham H, Schadt C, Chisolm S. et al. Evidence supports blind screening for internal malignancy in dermatomyositis: Data from 2 large US dermatology cohorts. Medicine (Baltimore) 2018; 97: e9639
• 15 Li H, Altman RD, Yao Q. RS3PE: Clinical and Research Development. Curr Rheumatol Rep 2015; 17: 49
• 16 Lundberg IE, Tjärnlund A, Bottai M. et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Annals of the rheumatic diseases 2017; 76: 1955
• 17 Manger B, Lindner A, Manger K. et al. Hypertrophe Osteoarthropathie. Zeitschrift für Rheumatologie 2011; 70: 554
• 18 Manger B, Schett G. Palmar fasciitis and polyarthritis syndrome—Systematic literature review of 100 cases. Seminars in Arthritis and Rheumatism 2014; 44: 105-111
• 19 Manger B, Schett G. Paraneoplastic syndromes in rheumatology. Nature Reviews Rheumatology 2014; 10: 662-670
• 20 Manger B, Schett G. Rheumatic paraneoplastic syndromes – A clinical link between malignancy and autoimmunity. Clinical Immunology 2018; 186: 67-70
• 21 Manger B, Wacker J, Schmidt D. et al. Clinical Images: Hippokrates confirmed by positron emission tomography. Arthritis & Rheumatism 2011; 63: 1150-1150
• 22 Martinez-Lavin M. Exploring the Cause of the Most Ancient Clinical Sign of Medicine: Finger Clubbing. Seminars in Arthritis and Rheumatism 2007; 36: 380-385
• 23 Medsger TA, Dixon JA, Garwood VF. Palmar Fasciitis and Polyarthritis Associated with Ovarian Carcinoma. Annals of Internal Medicine 1982; 96: 424-431
• 24 Narváez J, Bianchi MM, Santo P. et al. Pancreatitis, Panniculitis, and Polyarthritis. Seminars in Arthritis and Rheumatism 2010; 39: 417-423
• 25 Origuchi T, Arima K, Kawashiri SY. et al. High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome. Modern Rheumatology 2012; 22: 584-588
• 26 Podjasek JO, Wetter DA, Pittelkow MR. et al. Henoch-Schonlein purpura associated with solid-organ malignancies: three case reports and a literature review. Acta Derm Venereol 2012; 92: 388-392
• 27 Price S, Spencer A, Medina-Lara A. et al. Availability and use of cancer decision-support tools: a cross-sectional survey of UK primary care. British Journal of General Practice 2019; 69: e437
• 28 Qiang JK, Kim WB, Baibergenova A. et al. Risk of Malignancy in Dermatomyositis and Polymyositis: A Systematic Review and Meta-Analysis. Journal of Cutaneous Medicine and Surgery 2016; 21: 131-136
• 29 Schmalzing M. Paraneoplastische Syndrome in der Rheumatologie. Zeitschrift für Rheumatologie 2018; 77: 309-321
• 30 Scholtissek B, Ferring-Schmitt S, Maier J. et al. Expression of the autoantigen TRIM33/TIF1γ in skin and muscle of patients with dermatomyositis is upregulated, together with markers of cellular stress. Clinical and Experimental Dermatology 2017; 42: 659-662
• 31 Selva-O'callaghan A, Martinez-Gomez X, Trallero-Araguas E. et al. The diagnostic work-up of cancer-associated myositis. Curr Opin Rheumatol 2018; 30: 630-636
• 32 Sigurgeirsson B, Lindelöf B, Edhag O. et al. Risk of Cancer in Patients with Dermatomyositis or Polymyositis. New England Journal of Medicine 1992; 326: 363-367
• 33 Solans-Laqué R, Bosch-Gil JA, Pérez-Bocanegra C. et al. Paraneoplastic vasculitis in patients with solid tumors: Report of 15 cases. Journal of Rheumatology 2008; 35: 294-304
• 34 Trallero-Araguás E, Rodrigo-Pendás JÁ, Selva-O'callaghan A. et al. Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: A systematic review and meta-analysis. Arthritis & Rheumatism 2012; 64: 523-532
• 35 Yang H, Peng Q, Yin L. et al. Identification of multiple cancer-associated myositis-specific autoantibodies in idiopathic inflammatory myopathies: a large longitudinal cohort study. Arthritis research & therapy 2017; 19: 259
• 36 Zundler S, Erber R, Agaimy A. et al. Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature. BMC Cancer 2016; 16: 130