Z Orthop Unfall 2021; 159(06): 617-623
DOI: 10.1055/a-1219-8274
Review/Übersicht

Cartilage Regeneration with a Cell-free Collagen Type 1 Matrix (Part 2 – Experimental Aspects)

Article in several languages: English | deutsch
1   OPM – Orthopädische Praxisklinik Mayen, Germany
2   Medizinische Fakultät, Fachbereich Orthopädie und Unfallchirurgie, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany
,
Ralf Mueller-Rath
3   OPND – Orthopädische Praxisklinik Neuss-Düsseldorf, Germany
4   Medizinische Fakultät, Orthopädie, Rheinisch-Westfälische Technische Hochschule Aachen, Germany
,
Dieter Christian Wirtz
5   Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Germany
,
5   Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn, Germany
› Author Affiliations

Abstract

Cartilage regeneration with cell-free matrices has developed from matrix-associated autologous cartilage cell transplantation (MACT) over ten years ago. Adjustments to the legal framework and higher hurdles for cell therapy have led to the procedures being established as an independent alternative to MACT. These procedures, which can be classified as matrix-induced autologous cartilage regeneration (MACR), all rely on the chemotactic stimulus of a cross-linked matrix, which mostly consists of collagens. Given the example of a commercially available type I collagen hydrogel, the physicochemical properties of such a matrix are explained and the available experimental data highlighted in more detail. The interaction between different cell types and the chemotactic properties of the collagen has been investigated extensively and, from a clinical point of view, today offers various reference points for a smart modification of the described method to further improve clinical outcomes. Since the origin of the cells in the ultimately formed repair tissue is still unrevealed, further investigations to clarify the exact mechanism are crucially needed.



Publication History

Article published online:
12 October 2020

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