Neurologie up2date, Table of Contents Neurologie up2date 2021; 4(02): 131-146DOI: 10.1055/a-1313-1623 Immunvermittelte und erregerbedingte Erkrankungen des ZNS Neurologische Komplikationen bei COVID-19-Infektion Eileen Gülke , Christian GerloffRecommend Article Abstract Buy Article All articles of this category Seit ersten Berichten einer neuen Atemwegsinfektion aus der Hauptstadt Wuhan der zentralchinesischen Provinz Hubei Ende 2019 breitet sich das Coronavirus SARS-CoV-2 weltweit aus. Mittlerweile ist bekannt, dass eine COVID-19-Infektion häufig begleitet wird von neurologischen Symptomen und Komplikationen. Dieser Artikel beleuchtet die klinische Relevanz der COVID-19-Pandemie für die Neurologie im Allgemeinen und insbesondere im Hinblick auf an Parkinson vorerkrankte Patienten. Full Text References Literatur 1 Matheson NJ, Lehner PJ. How does SARS-CoV-2 cause COVID-19?. Science 2020; 369: 510-511 2 He X, Lau EHY, Wu P. et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med 2020; 26: 672-675 3 Khan S, Gomes J. Neuropathogenesis of SARS-CoV-2 infection. Elife 2020; 9 4 Zubair AS, McAlpine LS, Gardin T. et al. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. JAMA Neurol 2020; 77: 1018-1027 5 van Riel D, Verdijk R, Kuiken T. The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. J Pathol 2015; 235: 277-287 6 Kandemirli SG, Altundag A, Yildirim D. et al. Olfactory bulb MRI and paranasal sinus CT findings in persistent COVID-19 anosmia. Acad Radiol 2021; 28: 28-35 7 Fotuhi M, Mian A, Meysami S. et al. Neurobiology of COVID-19. J Alzheimers Dis 2020; 76: 3-19 8 Ellul MA, Benjamin L, Singh B. et al. Neurological associations of COVID-19. Lancet Neurol 2020; 19: 767-783 9 Matschke J, Lütgehetmann M, Hagel C. et al. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol 2020; 19: 919-929 10 Yanai H. Metabolic Syndrome and COVID-19. Cardiol Res 2020; 11: 360-365 11 Madia F, Merico B, Primiano G. et al. Acute myopathic quadriplegia in patients with COVID-19 in the intensive care unit. Neurology 2020; 95: 492-494 12 Mao L, Jin H, Wang M. et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 2020; 77: 683-690 13 Moro E, Priori A, Beghi E. et al. The international European Academy of Neurology survey on neurological symptoms in patients with COVID-19 infection. Eur J Neurol 2020; 27: 1727-1737 14 Liotta EM, Batra A, Clark JR. et al. Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients. Ann Clin Transl Neurol 2020; 7: 2221-2230 15 Kennedy M, Helfand BKI, Gou RY. et al. Delirium in older patients with COVID-19 presenting to the emergency department. JAMA Netw Open 2020; 3: e2029540 16 Cilia R, Bonvegna S, Straccia G. et al. Effects of COVID-19 on Parkinsonʼs disease clinical features: A community-based case-control study. Mov Disord 2020; 35: 1287-1292 17 Paterson RW, Brown RL, Benjamin L. et al. The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain 2020; 143: 3104-3120 18 Frontera JA, Sabadia S, Lalchan R. et al. A prospective study of neurologic disorders in hospitalized COVID-19 patients in New York City. Neurology 2021; 96: e575-e586 19 Meppiel E, Peiffer-Smadja N, Maury A. et al. Neurologic manifestations associated with COVID-19: a multicentre registry. Clin Microbiol Infect 2021; 27: 458-466 20 Mizuguchi M, Yamanouchi H, Ichiyama T. et al. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand 2007; 115: 45-56 21 Mizuguchi M. Influenza encephalopathy and related neuropsychiatric syndromes. Influenza Other Respir Viruses 2013; 7 (Suppl. 03) 67-71 22 Glaser CA, Winter K, DuBray K. et al. A population-based study of neurologic manifestations of severe influenza A(H1N1)pdm09 in California. Clin Infect Dis 2012; 55: 514-520 23 Parauda SC, Gao V, Gewirtz AN. et al. Posterior reversible encephalopathy syndrome in patients with COVID-19. J Neurol Sci 2020; 416: 117019 24 Tan YK, Goh C, Leow AST. et al. COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature. J Thromb Thrombolysis 2020; 50: 587-595 25 Siegler JE, Cardona P, Arenillas JF. et al. Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry. Int J Stroke 30.09.2020; 26 Nannoni S, de Groot R, Bell S. et al. Stroke in COVID-19: A systematic review and meta-analysis. Int J Stroke 2021; 16: 137-149 27 Oxley TJ, Mocco J, Majidi S. et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med 2020; 382: e60 28 Fan BE, Umapathi T, Chua K. et al. Delayed catastrophic thrombotic events in young and asymptomatic post COVID-19 patients. J Thromb Thrombolysis 07.11.2020; 1-7 29 Bekelis K, Missios S, Ahmad J. et al. Ischemic stroke occurs less frequently in patients with COVID-19: A multicenter cross-sectional study. Stroke 2020; 51: 3570-3576 30 Nadkarni GN, Lala A, Bagiella E. et al. Anticoagulation, bleeding, mortality, and pathology in hospitalized patients with COVID-19. J Am Coll Cardiol 2020; 76: 1815-1826 31 Cuker A, Tseng EK, Nieuwlaat R. et al. American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19. Blood Adv 2021; 5: 872-888 32 Rentsch CT, Beckman JA, Tomlinson L. et al. Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study. BMJ 2021; 372: n311 33 Flam B, Wintzell V, Ludvigsson JF. et al. Direct oral anticoagulant use and risk of severe COVID-19. J Intern Med 2021; 289: 411-419 34 Ntaios G, Michel P, Georgiopoulos G. et al. Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke: The Global COVID-19 Stroke Registry. Stroke 2020; 51: e254-e258 35 Filosto M, Cotti PiccinelliS, Gazzina S. et al. Guillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions. J Neurol Neurosurg Psychiatry 06.11.2020; 36 Josephson SA, Kamel H. Neurology and COVID-19. Jama 2020; 324: 1139-1140 37 Cagnazzo F, Arquizan C, Derraz I. et al. Neurological manifestations of patients infected with the SARS-CoV-2: a systematic review of the literature. J Neurol 30.10.2020; 1-10 38 Cabañes-Martínez L, Villadóniga M, González-Rodríguez L. et al. Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol 2020; 131: 2809-2816 39 Restivo DA, Centonze D, Alesina A. et al. Myasthenia gravis associated with SARS-CoV-2 infection. Ann Intern Med 2020; 173: 1027-1028 40 Méndez-Guerrero A, Laespada-García MI, Gómez-Grande A. et al. Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection. Neurology 2020; 95: e2109-e2118 41 Chaumont H, San-Galli A, Martino F. et al. Mixed central and peripheral nervous system disorders in severe SARS-CoV-2 infection. J Neurol 2020; 267: 3121-3127 42 Helmich RC, Bloem BR. The impact of the COVID-19 pandemic on Parkinsonʼs disease: Hidden sorrows and emerging opportunities. J Parkinsons Dis 2020; 10: 351-354 43 Brown EG, Chahine LM, Goldman SM. et al. The effect of the COVID-19 pandemic on people with Parkinsonʼs disease. J Parkinsons Dis 2020; 10: 1365-1377 44 Neumann-Haefelin T, Faiss J, Glahn J. et al. Schlaganfallversorgung in Deutschland während der frühen Phase der COVID-19-Pandemie. DGNeurologie 2020; 3: 478-484 45 Jasne AS, Chojecka P, Maran I. et al. Stroke code presentations, interventions, and outcomes before and during the COVID-19 pandemic. Stroke 2020; 51: 2664-2673 46 Blecker S, Jones SA, Petrilli CM. et al. Hospitalizations for chronic disease and acute conditions in the time of COVID-19. JAMA Intern Med 2021; 181: 269-271 47 Richter D, Eyding J, Weber R. et al. Analysis of nationwide stroke patient care in times of COVID-19 pandemic in Germany. Stroke 2021; 52: 716-721 48 Zhao J, Li H, Kung D. et al. Impact of the COVID-19 epidemic on stroke care and potential solutions. Stroke 2020; 51: 1996-2001 49 Tiedt S, Bode FJ, Uphaus T. et al. Impact of the COVID-19-pandemic on thrombectomy services in Germany. Neurol Res Pract 2020; 2: 44 50 Williamson EJ, Walker AJ, Bhaskaran K. et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020; 584: 430-436 51 Romagnolo A, Balestrino R, Imbalzano G. et al. Neurological comorbidity and severity of COVID-19. J Neurol 2021; 268: 762-769 52 Kovvuru S, Nalleballe K, Onteddu SR. et al. Immunosuppression in chronic autoimmune neurological disorders during the COVID-19 pandemic. J Neurol Sci 2021; 420 53 Zhang Q, Schultz JL, Aldridge GM. et al. Coronavirus disease 2019 case fatality and Parkinsonʼs disease. Mov Disord 2020; 35: 1914-1915 54 Ferini-Strambi L, Salsone M. COVID-19 and neurological disorders: are neurodegenerative or neuroimmunological diseases more vulnerable?. J Neurol 2021; 268: 409-419 55 Hribar CA, Cobbold PH, Church FC. Potential role of vitamin D in the elderly to resist COVID-19 and to slow progression of Parkinsonʼs disease. Brain Sci 2020; 10 56 Leung K, Shum MH, Leung GM. et al. Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020. Euro Surveill 2021; 26 57 Hou YJ, Chiba S, Halfmann P. et al. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science 2020; 370: 1464-1468 58 Goërtz YMJ, Van Herck M, Delbressine JM. et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome?. ERJ Open Res 2020; 6 59 Nehme M, Braillard O, Alcoba G. et al. COVID-19 Symptoms: Longitudinal evolution and persistence in outpatient settings. Ann Intern Med 08.12.2020; 60 Kedor C, Freitag H, Meyer-Arndt L. et al. Chronic COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) following the first pandemic wave in Germany – a first analysis of a prospective observational study. MedRxiv 2021; 61 Woo MS, Malsy J, Pöttgen J. et al. Frequent neurocognitive deficits after recovery from mild COVID-19. Brain Commun 2020; 2: fcaa205. 62 Méndez R, Balanzá-Martínez V, Luperdi SC. et al. Short-term neuropsychiatric outcomes and quality of life in COVID-19 survivors. J Intern Med 03.02.2021; 63 Heneka MT, Golenbock D, Latz E. et al. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 2020; 12: 69 64 Fazzini E, Fleming J, Fahn S. Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease. Mov Disord 1992; 7: 153-158 65 Tulisiak CT, Mercado G, Peelaerts W. et al. Can infections trigger alpha-synucleinopathies?. Prog Mol Biol Transl Sci 2019; 168: 299-322 66 Boika AV. A Post-COVID-19 Parkinsonism in the future?. Mov Disord 2020; 35: 1094 67 Sulzer D, Antonini A, Leta V. et al. COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside. NPJ Parkinsons Dis 2020; 6: 18 68 Chaudhry ZL, Klenja D, Janjua N. et al. COVID-19 and Parkinson's Disease: Shared inflammatory pathways under oxidative stress. Brain Sci 2020; 10 69 Follmer C. Gut microbiome imbalance and neuroinflammation: Impact of COVID-19 on Parkinsonʼs disease. Mov Disord 2020; 35: 1495-1496