Klin Monbl Augenheilkd 2021; 238(03): 267-271
DOI: 10.1055/a-1315-1331
Übersicht

Surgical Aspects in Gene Therapy for Inherited Retinal Diseases

Artikel in mehreren Sprachen: English | deutsch
M. Dominik Fischer
1   Department für Augenheilkunde, Universitäts-Augenklinik, Universitätsklinikum Tübingen, Deutschland
2   Nuffield Laboratory of Ophthalmology, University of Oxford, United Kingdom of Great Britain and Northern Ireland
,
Karl Ulrich Bartz-Schmidt
1   Department für Augenheilkunde, Universitäts-Augenklinik, Universitätsklinikum Tübingen, Deutschland
,
Spyridon Dimopoulos
1   Department für Augenheilkunde, Universitäts-Augenklinik, Universitätsklinikum Tübingen, Deutschland
,
Philipp Herrmann
3   Augenklinik, Universitätsklinikum Bonn, Deutschland
,
Maximilian Gerhardt
4   Augenklinik der LMU, Klinikum der Universität München, Deutschland
,
Frank G. Holz
3   Augenklinik, Universitätsklinikum Bonn, Deutschland
,
Siegfried Priglinger
4   Augenklinik der LMU, Klinikum der Universität München, Deutschland
› Institutsangaben

Abstract

Inherited retinal dystrophies (IRD) have been studied since their recognition by Franz Donders and Albrecht von Graefe. It nevertheless took 100 years for a causal therapy to take shape in the form of gene therapy: The approval of Voretigen Neparvovec (VN) for the treatment of hereditary retinal dystrophies due to RPE65 mutations was thus a significant milestone – for the era of personalised medicine in general and ophthalmology in particular. The clinical management around gene therapy applications is complex and requires the cooperation of various experts as a multidisciplinary team. This article describes the requirements, challenges, approaches, and open questions regarding the surgical aspects of gene therapy for retinal dystrophies. The first part outlines the standard surgical treatment. Based on this standard, alternative approaches are indicated for each individual step and their value discussed. Knowledge gaps are defined and in the outlook we speculate on future developments.



Publikationsverlauf

Eingereicht: 15. November 2020

Angenommen: 20. Dezember 2020

Artikel online veröffentlicht:
22. Februar 2021

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