Horm Metab Res 2021; 53(03): 197-203
DOI: 10.1055/a-1322-3160
Endocrine Research

Overexpression of miR-127 Predicts Poor Prognosis and Contributes to the Progression of Papillary Thyroid Cancer by Targeting REPIN1

Yinghe Sun
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Wenhai Sun
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Hui Hua
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Jianhua Zhang
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Qianqian Yu
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Jueru Wang
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Xiaomin Liu
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
,
Anbing Dong
1  Department of Thyroid Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P. R. China
› Author Affiliations

Abstract

Papillary thyroid cancer (PTC) is a major kind of thyroid cancer with increasing recurrence and metastasis. MiR-127 has been demonstrated to play roles in many cancers with dysregulation. However, the function of miR-127 is still unknown. This study aimed to explore a novel biomarker for the progression and prognosis of PTC. A set of 118 patients with PTC were collected from the Affiliated Hospital of Qingdao University. qRT-PCR was used to detect the expression of miR-127 in PTC tissues and cells. The association between miR-127 expression and the clinicopathological features of patients were evaluated by the χ2 test, and the prognostic value of miR-127 was evaluated by Kaplan–Meier analysis and Cox regression analysis. The effect of miR-127 on cell proliferation, migration, and invasion of PTC was analyzed by CCK-8 and transwell assay. miR-127 was found to be upregulated in PTC tissues and cells correlated with the TNM stage and poor prognosis of PTC patients. MiR-127 and the TNM stage were considered as two independent prognostic indicators for PTC. Moreover, overexpression of miR-127 significantly enhanced cell proliferation, migration, and invasion of PTC by targeting REPIN1. miR-127 may be involved in the progression of PTC, which provides a new therapeutic strategy for PTC.



Publication History

Received: 25 August 2020

Accepted: 16 November 2020

Publication Date:
18 December 2020 (online)

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