Coronary Plaque Erosion after Abemaciclib Treatment Onset: An Unknown Side Effect?

Abstract

The current article describes a 72-year-old woman who suffered an acute myocardial infarction due to plaque erosion (PE) 2 weeks after abemaciclib treatment onset due to advanced breast cancer. Abemaciclib is a cyclin-dependent kinase 4 and 6 inhibitor that has recently demonstrated efficacy and safety in advanced breast cancer. Of major concern, however, reported thromboembolic rates in randomized clinical trials testing this drug range from 0.6 to 5%. To the best of our knowledge this is the first thrombotic coronary side effect ever reported. We suggest that a treatment that increases thromboembolic risk, such abemaciclib, may have triggered PE in our patient, 15 days after abemaciclib initiation. New molecules are promising in cancer treatment; however, care must be paid to their potential cardiotoxic effects.

Keywords

thrombosis - acute myocardial infarction - cardiology

Publication History

Received: 07 November 2020

Accepted: 27 November 2020

Accepted Manuscript online:
01 December 2020

Article published online:
06 February 2021

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