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Hamostaseologie 2021; 41(01): 022-024
DOI: 10.1055/a-1339-7401
Review Article

New Opportunities for Diagnosis and Prognosis of Stroke: The Benefits of Across Border Approaches

Denis Vivien
1   Normandie Univ, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France
2   CHU Caen, Department of Clinical Research, CHU Caen Côte de Nacre, Caen, France
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Abstract

Ischemic stroke is a leading cause of disability, with its treatment not yet optimal. It is thus mandatory to make preclinical research on this topic more efficient. This review summarizes current development of research aimed to improve diagnosis and prognosis of ischemic stroke. For more details, see our recent review published in Lancet Neurology.

Keywords

stroke/prevention - imaging - animal models - proteases


Publication History

Received: 21 August 2020

Accepted: 17 December 2020

Article published online:
15 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Powers WJ, Rabinstein AA, Ackerson T. et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2019; 50 (12) e344-e418
    CrossrefPubMedGoogle Scholar
  • 2 Thiebaut AM, Gauberti M, Ali C. et al. The role of plasminogen activators in stroke treatment: fibrinolysis and beyond. Lancet Neurol 2018; 17 (12) 1121-1132
    CrossrefPubMedGoogle Scholar
  • 3 Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I. et al. Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism. Blood 2016; 128 (20) 2423-2434
    CrossrefPubMedGoogle Scholar
  • 4 Lesept F, Chevilley A, Jezequel J. et al. Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors. Cell Death Dis 2016; 7 (11) e2466
    CrossrefPubMedGoogle Scholar
  • 5 Martinez de Lizarrondo S, Gakuba C, Herbig BA. et al. Potent thrombolytic effect of N-acetylcysteine on arterial thrombi. Circulation 2017; 136 (07) 646-660
    CrossrefPubMedGoogle Scholar
  • 6 Gauberti M, Fournier AP, Docagne F, Vivien D, Martinez de Lizarrondo S. Molecular magnetic resonance imaging of endothelial activation in the central nervous system. Theranostics 2018; 8 (05) 1195-1212
    CrossrefPubMedGoogle Scholar
  • 7 Quenault A, Martinez de Lizarrondo S, Etard O. et al. Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack. Brain 2017; 140 (01) 146-157
    CrossrefPubMedGoogle Scholar
  • 8 Fournier AP, Quenault A, Martinez de Lizarrondo S. et al. Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin. Proc Natl Acad Sci U S A 2017; 114 (23) 6116-6121
    CrossrefPubMedGoogle Scholar
  • 9 Fournier AP, Martinez de Lizarrondo S, Rateau A. et al. Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice. Sci Transl Med 2020; 12 (560) 4047
    CrossrefPubMedGoogle Scholar
  • 10 Hingot V, Brodin C, Lebrun F. et al. Early ultrafast ultrasound imaging of cerebral perfusion correlates with ischemic stroke outcomes and responses to treatment in mice. Theranostics 2020; 10 (17) 7480-7491
    CrossrefPubMedGoogle Scholar