New Opportunities for Diagnosis and Prognosis of Stroke: The Benefits of Across Border Approaches

Abstract

Ischemic stroke is a leading cause of disability, with its treatment not yet optimal. It is thus mandatory to make preclinical research on this topic more efficient. This review summarizes current development of research aimed to improve diagnosis and prognosis of ischemic stroke. For more details, see our recent review published in Lancet Neurology.

Keywords

stroke/prevention - imaging - animal models - proteases

Publikationsverlauf

Eingereicht: 21. August 2020

Angenommen: 17. Dezember 2020

Artikel online veröffentlicht:
15. Februar 2021

• References

• 1 Powers WJ, Rabinstein AA, Ackerson T. et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2019; 50 (12) e344-e418
• 2 Thiebaut AM, Gauberti M, Ali C. et al. The role of plasminogen activators in stroke treatment: fibrinolysis and beyond. Lancet Neurol 2018; 17 (12) 1121-1132
• 3 Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I. et al. Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism. Blood 2016; 128 (20) 2423-2434
• 4 Lesept F, Chevilley A, Jezequel J. et al. Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors. Cell Death Dis 2016; 7 (11) e2466
• 5 Martinez de Lizarrondo S, Gakuba C, Herbig BA. et al. Potent thrombolytic effect of N-acetylcysteine on arterial thrombi. Circulation 2017; 136 (07) 646-660
• 6 Gauberti M, Fournier AP, Docagne F, Vivien D, Martinez de Lizarrondo S. Molecular magnetic resonance imaging of endothelial activation in the central nervous system. Theranostics 2018; 8 (05) 1195-1212
• 7 Quenault A, Martinez de Lizarrondo S, Etard O. et al. Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack. Brain 2017; 140 (01) 146-157
• 8 Fournier AP, Quenault A, Martinez de Lizarrondo S. et al. Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin. Proc Natl Acad Sci U S A 2017; 114 (23) 6116-6121
• 9 Fournier AP, Martinez de Lizarrondo S, Rateau A. et al. Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice. Sci Transl Med 2020; 12 (560) 4047
• 10 Hingot V, Brodin C, Lebrun F. et al. Early ultrafast ultrasound imaging of cerebral perfusion correlates with ischemic stroke outcomes and responses to treatment in mice. Theranostics 2020; 10 (17) 7480-7491