Pharmacopsychiatry 2021; 54(02): 91-95
DOI: 10.1055/a-1353-6509
Original Paper

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States

Daniel E. Kaufman
1  Geisinger Commonwealth School of Medicine, Scranton, PA, USA
,
Asawer M. Nihal
1  Geisinger Commonwealth School of Medicine, Scranton, PA, USA
,
Janan D. Leppo
1  Geisinger Commonwealth School of Medicine, Scranton, PA, USA
,
Kelly M. Staples
1  Geisinger Commonwealth School of Medicine, Scranton, PA, USA
,
Kenneth L. McCall
2  University of New England, Portland, ME, USA
,
Brian J. Piper
1  Geisinger Commonwealth School of Medicine, Scranton, PA, USA
3  Center for Pharmacy Innovation and Outcomes, Forty Fort, PA, USA
› Author Affiliations
Funding: Prior research has been supported by NIDA and the Center for Wellness Leadership, travel by cannabis patient organizations (e.g. Patients Out of Time). Current research on osteoarthritis is supported by Pfizer and Eli Lilly.

Abstract

Introduction The United States is in the midst of an opioid overdose epidemic. Emerging evidence suggests that medical cannabis (MC) may reduce use of opioids for pain in some individuals, with potential impacts on opioid-related overdose. However, there may be other important differences between states that did, and did not, adopt MC.

Methods This study evaluated differences following legal MC sales on US opioid-related overdose deaths, corrected for population, from 1999 to 2017 using an interrupted time series. Comparisons by MC status were also made for Medicaid expansion and the Centers for Disease Control death certificate reporting quality (0: <good, 1: good, 2: excellent).

Results Overdose deaths were significantly higher in MC states from 2012–2017. Overdose death slopes over time increased in states with (pre=1.46±0.46, post=2.90±0.58, p<0.05) and without (pre =0.20±.10, post=1.04±0.22, p<0.005) MC. Post-legalization slopes were significantly higher in MC states (p<0.01). Two states without (11.1%) as compared to 11 states with (91.7%) MC expanded Medicaid by 2014 (χ2[1]=19.03, p<0.0005). MC states (1.50±0.23) had higher death certificate reporting quality relative to states without MC (0.78±0.22, p<0.05).

Discussion MC states had higher rates of opioid overdoses. Although there was no decrease in association with MC introduction, these results were confounded by states without MC having lower overdose reporting quality. Medicaid expansion was also more common in states with MC. Finally, the potency of fentanyl analogues may have obscured any protective effects of MC against illicit opioid harms.

Supplementary Material



Publication History

Received: 21 June 2020
Received: 09 December 2020

Accepted: 04 January 2021

Publication Date:
23 February 2021 (online)

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