CC BY-NC-ND 4.0 · Int J Sports Med
DOI: 10.1055/a-1403-2701
Physiology & Biochemistry

No Influence of Nonivamide-nicoboxil on the Peak Power Output in Competitive Sportsmen

1  Department of Clinical Research, German Centre for Neurodegenerative Diseases, Bonn, Germany
,
Yvonne Wahl
5  Insitute of Exercise Training and Sport Informatics, German Sport University Cologne, Cologne, Germany
,
Christian Brinkmann
3  Department of Preventive and Rehabilitative Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany
,
Wilhelm Bloch
2  The German Research Centre of Elite Sport, German Sport University Cologne, Cologne, Germany
4  Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sports Medicine, German Sport University Cologne, Cologne, Germany
,
Patrick Wahl
2  The German Research Centre of Elite Sport, German Sport University Cologne, Cologne, Germany
4  Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sports Medicine, German Sport University Cologne, Cologne, Germany
6  Institute of Interdisciplinary Exercise Science and Sports Medicine, Medical School Hamburg, Germany
› Author Affiliations

Abstract

Recent studies have shown that the oxygenated hemoglobin level can be enhanced during rest through the application of nonivamide-nicoboxil cream. However, the effect of nonivamide-nicoboxil cream on oxygenation and endurance performance under hypoxic conditions is unknown. Therefore, the purpose of this study was to investigate the effects of nonivamide-nicoboxil cream on local muscle oxygenation and endurance performance under normoxic and hypoxic conditions. In a cross-over design, 13 athletes (experienced cyclists or triathletes [age: 25.2±3.5 years; VO2max 62.1±7.3 mL·min−1·kg−1]) performed four incremental exercise tests on the cycle ergometer under normoxic or hypoxic conditions, either with nonivamide-nicoboxil or placebo cream. Muscle oxygenation was recorded with near-infrared spectroscopy. Capillary blood samples were taken after each step, and spirometric data were recorded continuously. The application of nonivamide-nicoboxil cream increased muscle oxygenation at rest and during different submaximal workloads as well as during physical exhaustion, irrespective of normoxic or hypoxic conditions. Overall, there were no significant effects of nonivamide-nicoboxil on peak power output, maximal oxygen uptake or lactate concentrations. Muscle oxygenation is significantly higher with the application of nonivamide-nicoboxil cream. However, its application does not increase endurance performance.



Publication History

Received: 20 September 2020

Accepted: 16 February 2021

Publication Date:
15 April 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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