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CC BY 4.0 · Int J Sports Med 2021; 42(13): 1174-1181
DOI: 10.1055/a-1422-3376
Physiology & Biochemistry

Acute Response of Sclerostin to Whole-body Vibration with Blood Flow Restriction

Kyle S Gapper
1   Department of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom of Great Britain and Northern Ireland
,
Sally Stevens
1   Department of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom of Great Britain and Northern Ireland
,
Rona Antoni
1   Department of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom of Great Britain and Northern Ireland
,
Julie Hunt
1   Department of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom of Great Britain and Northern Ireland
,
Sarah J Allison
1   Department of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom of Great Britain and Northern Ireland
› Author Affiliations Funding This study was funded by the University of Surrey Pump Priming Award.
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Abstract

Blood flow restriction may augment the skeletal response to whole-body vibration. This study used a randomised, crossover design to investigate the acute response of serum sclerostin and bone turnover biomarkers to whole-body vibration with blood flow restriction. Ten healthy males (mean±standard deviation; age: 27±8 years) completed two experimental conditions separated by 7 days: (i) whole-body vibration (10 1-minute bouts of whole-body vibration with 30 s recovery) or (ii) whole-body vibration with lower-body blood flow restriction (10 cycles of 110 mmHg inflation with 30 s deflation during recovery). Fasting blood samples were obtained immediately before and immediately after exercise, then 1 hour, and 24 hours after exercise. Serum samples were analysed for sclerostin, cross-linked C-terminal telopeptide of type I collagen, and bone-specific alkaline phosphatase. There was a significant time × condition interaction for bone-specific alkaline phosphatase (p=0.003); bone-specific alkaline phosphatase values at 24 hours post-exercise were significantly higher following whole-body vibration compared to combined whole-body vibration and blood flow restriction (p=0.028). No significant time × condition interaction occurred for any other outcome measure (p>0.05). These findings suggest that a single session of whole-body vibration combined with blood flow restriction does not significantly affect serum sclerostin or bone turnover biomarkers.

Key words

bone metabolism - bone turnover markers - blood flow restriction - vibration - acute response


Publication History

Received: 23 March 2020

Accepted: 27 February 2021

Article published online:
11 May 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
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