Pivotal Reactions in the Creation of the Polycyclic Skeleton of Cryptotrione

Zhuliang Zhong; Mao-Yun Lyu; Hao-Ran Ma; Henry N. C. Wong; Xiao-Shui Peng

doi:10.1055/a-1472-4594

Synlett, Table of Contents

Synlett 2021; 32(18): 1796-1815
DOI: 10.1055/a-1472-4594

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Pivotal Reactions in the Creation of the Polycyclic Skeleton of Cryptotrione

Authors

Zhuliang Zhong

^bDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
Mao-Yun Lyu

^bDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
Hao-Ran Ma

^aSchool of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China
Henry N. C. Wong∗

^aSchool of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China

^bDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China
Xiao-Shui Peng ∗

^aSchool of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China

^bDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China

Abstract

All articles of this category

Dedicated to the memory of Professor Shang-Wai Tam, who passed away January 1, 2021

Abstract

Three pivotal reactions, namely, enyne cycloisomerization, polyene cyclization, and quinone methide formation, are applied to synthesize the complex polycyclic skeleton of cryptotrione. This review summarizes the most prominent applications of these three reactions to the total syntheses of natural products, covering results published in the literature between 2011 and 2020.

1 Introduction

2 Three Pivotal Reactions Applied to Create the Polycyclic Framework of Cryptotrione

2.1 Enyne Cycloisomerization

2.2 Polyene Cyclization

2.3 Quinone Methide Formation

3 Conclusion

Key words

total synthesis - natural products - enyne cycloisomerization - polyene cyclization - quinone methides

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References

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