Zellbasierte Therapeutika zur Behandlung der Osteoarthritis beim Pferd

Susanne P. Roth; Walter Brehm; Antonia Troillet

doi:10.1055/a-1482-7752

Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere, Table of Contents

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021; 49(03): 189-202
DOI: 10.1055/a-1482-7752

Übersichtsartikel

Zellbasierte Therapeutika zur Behandlung der Osteoarthritis beim Pferd

Grundlagenwissen für den PraktikerCell-based therapeutic strategies for osteoarthritis in equine patientsBasic knowledge for clinical practitioners

Susanne P. Roth

¹Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig

²Sächsischer Inkubator für Klinische Translation, Universität Leipzig

,

Walter Brehm

¹Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig

²Sächsischer Inkubator für Klinische Translation, Universität Leipzig

,

Antonia Troillet

¹Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig

²Sächsischer Inkubator für Klinische Translation, Universität Leipzig

› Author Affiliations

Abstract

Zusammenfassung

In den letzten Jahren haben zellbasierte Therapeutika zur Behandlung von Osteoarthritiden in der Pferdemedizin einen regelrechten Boom erlebt. In der Praxis werden diese Therapeutika in Eigenverantwortung des Tierarztes aus Patientenblut oder anderen körpereigenen Geweben wie Fettgewebe oder Knochenmark hergestellt. Auch wenn diesen zellbasierten Therapiemethoden das einheitliche therapeutische Konzept der regenerativen Medizin gemein ist, unterscheiden sie sich maßgeblich hinsichtlich Herstellungsverfahren, Inhaltsstoffen und Funktionsweisen. Grundlegendes Wissen hierzu ermöglicht es dem praktizierenden Tierarzt, das für ihn und seine Pferdepatienten geeignete Produkt auszuwählen und bestmögliche Behandlungsstrategien zu erstellen.

Abstract

Cell-based therapies for the treatment of osteoarthritis in equine patients experienced a real boom within the last few years. In every day medical practice, attending veterinary surgeons extract patient’s blood or other autologous tissue samples and process the material for the purpose of administering the resulting product to the same patient under their own responsibility. Although being consistently classified as treatment option within the framework of regenerative medicine, the manufacturing processes, ingredients, and mechanisms of action remain highly diverse among cell-based therapies. Thus, sound knowledge about the latter ones forms the basis for therapeutic decision-making and best possible treatment regimes.

Schlüsselwörter

Regenerative Medizin - Orthopädie - Gelenk - blutbasierte Therapien - Stammzellen

Key words

Regenerative medicine - orthopaedics - joint - blood-derived products - stem cells

Full Text

References

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