CC BY-NC-ND 4.0 · Horm Metab Res 2021; 53(08): 529-540
DOI: 10.1055/a-1510-8896
Endocrine Care

Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic Syndrome

Markus Rohner
1   EGB EpiGeneticBalance AG, Rheinfelden, Switzerland
Robert Heiz
2   Zentrum für Komplementärmedizin AG, Uster, Switzerland
Simon Feldhaus
3   Paramed AG, Haldenstrasse 1, Baar, Switzerland
Stefan R. Bornstein
4   Department of Medicine, Technische Universität Dresden, Dresden, Germany
› Author Affiliations


Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient insulin resistance remission. Treating insulin resistance with a molecular nutrition-centered approach shifts the treatment paradigm of Type 2 Diabetes from management to cure. This allows remission within five months, with a high efficiency rate of 85%. With molecular intermittent fasting a very efficient treatment for prediabetes and metabolic syndrome is possible, improving the non-alcoholic fatty liver disease (NAFL) state and enabling the body to lose weight in a sustainable manner.

Publication History

Received: 09 February 2021

Accepted after revision: 12 May 2021

Article published online:
30 June 2021

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