CC BY-NC-ND 4.0 · Dtsch Med Wochenschr 2022; 147(01/02): 62-68
DOI: 10.1055/a-1516-2471

State of the Art: Therapie mit Statinen

State of the Art: Statin Therapy
Ulrich Laufs
Oliver Weingärtner
Ursula Kassner
Ulrike Schatz

Im Jahr 2020 wurden hierzulande 2,7 Milliarden Statin-Tabletten verordnet, das entspricht bei täglicher Einnahme 7,6 Millionen Menschen in Deutschland [1]. Daher hat jeder Internist oder Allgemeinmediziner täglich mit Statin-Verschreibungen zu tun. Die vorliegende Übersichtsarbeit fasst die aktuelle Datenlage zur klinischen Pharmakologie und Wirksamkeit sowie zu Nebenwirkungen und speziellen Therapie-Situationen zusammen.


This review summarizes the pharmacology and clinical use of HMG-CoA reductase inhibitors, statins. LDL-Cholesterol lowering with statins reduces atherosclerotic cardiovascular risk by approx. one quater per year of treatment. The efficacy and safety of statins are demonstrated by randomized trials irrespective of the patient’s age. The synthetic statins, rosuvastatin and atorvastatin, are superior with regard to LDL-C lowering, half-life and drug-interactions compared to the older statins such as simvastatin. Modern lipid lowering therapy uses individualized statin-based combination therapies.

Publication History

Article published online:
06 December 2021

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