Therapieoptionen zur LDL-C-Senkung zusätzlich zu Statinen

Die aktuellen Leitlinien für Dyslipidämie heben Statine als Eckpfeiler der pharmakologischen Lipidsenkungstherapie hervor. Ezetimib, PCSK9-Antikörper sowie Bempedosäure und Inclisiran sind neu verfügbare Optionen zur weiteren Senkung des LDL-C. Da die moderne Lipidsenkungstherapie durch einen individuellen „Treat-to-Target“-Ansatz gekennzeichnet ist, soll dieser Beitrag zu einem besseren Verständnis des Cholesterinstoffwechsels beitragen, um den rationalen Einsatz früher individualisierter Kombinationstherapien zu unterstützen.

Abstract

Current dyslipidemia guidelines emphasize statins as the cornerstone of pharmacological lipid-lowering therapy. The cholesterol absorption inhibitor ezetimibe, PCSK9-antibodies, as well as bempedoic acid and inclisiran are newly available options to further reduce LDL-cholesterol. Since modern lipid-lowering therapy is characterized by an individual, “treat-to-target” approach the aim of this review is to provide a better understanding of cholesterol metabolism to guide decision-making and the rational for using early individualized combination therapies.

Schlüsselworter

Statin - Ezetimib - PCSK9I - Bempedoinsäure - Inclisiran - Cholesterin

Key words

statins - ezetimibe - PCSK9I - bempedoic acide - fibrates - inclisiran - cholesterol

Publikationsverlauf

Artikel online veröffentlicht:
01. August 2022

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