Application of Industrially Relevant HydroFluoroOlefin (HFO) Gases in Organic Syntheses

Bálint Varga; János T. Csenki; Balázs L. Tóth; Ferenc Béke; Zoltán Novák; András Kotschy

doi:10.1055/a-1538-8344

Synthesis, Table of Contents

Synthesis 2021; 53(23): 4313-4326
DOI: 10.1055/a-1538-8344

short review

Application of Industrially Relevant HydroFluoroOlefin (HFO) Gases in Organic Syntheses

Authors

Bálint Varga

^aELTE ‘Lendület’ Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Faculty of Science, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary
János T. Csenki

^aELTE ‘Lendület’ Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Faculty of Science, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary
Balázs L. Tóth

^aELTE ‘Lendület’ Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Faculty of Science, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary
Ferenc Béke

^aELTE ‘Lendület’ Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Faculty of Science, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary
Zoltán Novák ∗

^aELTE ‘Lendület’ Catalysis and Organic Synthesis Research Group, Institute of Chemistry, Faculty of Science, Eötvös Loránd University, Pázmány Péter stny. 1/A, 1117 Budapest, Hungary
András Kotschy ∗

^bServier Research Institute of Medicinal Chemistry, Záhony utca 7, 1031 Budapest, Hungary

Abstract

All articles of this category

Abstract

Hydrofluoroolefin (HFO) gases are state-of-the-art cooling agents with widespread household and industrial applications. Considering their structural benefits these fluorous feedstocks have gained the attention of organic chemists in the last couple of years. In this short review we summarized the existing synthetic transformations of these gaseous starting material and present their applicability in the synthesis of fluorine-containing organic molecules, which have potential importance as building blocks and reagents for diverse syntheses.

1 Introduction

2 Addition Reactions

3 Substitutions

4 Organometallic Chemistry

4.1 Organolithium Compounds

4.2 Organometallic Complexes

4.3 Silicon Organic Chemistry

4.4 Boron Organic Chemistry

4.5 Palladium-Catalyzed Transformations

4.6 Metathesis

4.7 Hydroesterification, Hydroformylation

5 Conclusions

Key words

HFO - hydrofluoroolefin - fluorine - fluoroalkylation - transition metals

Full Text

References

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