Asymmetric Synthesis of 3-Phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles Catalyzed by Phase-Transfer Catalyst Derived from tert-Leucine

Abstract

Chiral phase-transfer catalysts derived from tert-leucine were synthesized and used in the asymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of the corresponding products were obtained in excellent yield (up to 99%) with high enantio­selectivities (up to 91% ee) and diastereoselectivities (up to >99: 1 dr).

Key words

tert-leucine - 4-azaindolines - phase-transfer catalyst - enantiomers - intramolecular Mannich reaction

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