Synthesis, Table of Contents Synthesis 2022; 54(02): 451-464DOI: 10.1055/a-1624-2176 paper Facile and Straightforward Synthesis of Racemic Version of Substituted 3-[3-(2-Hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins: Easy Access to a Series of Biorelevant Warfarin Analogues Goutam Brahmachari ∗ , Mullicka Mandal , Indrajit KarmakarRecommend Article Abstract Buy Article All articles of this category Abstract The present communication deals with a straightforward, efficient, and green synthesis of a series of racemic version of 3-[3-(2-hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins as biologically interesting warfarin analogues upon decarboxylative hydrolysis of bis-coumarin derivatives in aqueous potassium hydroxide solution. The salient features of this practical method are operational simplicity, avoidance of any organic solvents and tedious column chromatographic purification, clean reaction profiles, excellent yields, and gram-scale synthetic applicability. Keywords Keywords3-[3-(2-hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins - warfarin analogues - water medium - cost-effective - green synthesis Full Text References References 1a Chen X, Liu Y, Furukawa N, Jin D.-Y, Savage GP, Stafford DW, Suhara Y, Williams CM, Tie J.-K. J. Thromb. Haemost. 2021; 19: 689 1b Wardrop D, Keeling D. Br. J. Haematol. 2008; 141: 757 1c Fasco MJ, Principe LM, Walsh WA, Friedman PA. Biochemistry 1983; 22: 5655 1d Bell RG, Caldwell PT. Biochemistry 1973; 12: 1759 1e Bell RG, Sadowski JA, Matschiner JT. Biochemistry 1972; 11: 1959 2a Dong J, Du D.-M. Org. Biomol. Chem. 2012; 10: 8125 2b Park BK. Biochem. Pharmacol. 1988; 37: 19 3a Ndadza A, Thomford NE, Mukanganyama S, Wonkam A, Ntsekhe M, Dandara C. OMICS 2019; 23: 152 3b Hylek EM, Evans-Molina C, Shea C, HenaultL E, Regan S. Circulation 2007; 115: 2689 3c Elliott MJ, Zimmerman D, Holden RM. Am. J. Kidney Dis. 2007; 50: 433 3d Pirmohamed M. Br. J. Clin. 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