Exp Clin Endocrinol Diabetes 2022; 130(S 01): S49-S79
DOI: 10.1055/a-1624-3388
German Diabetes Association: Clinical Practice Guidelines

Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents

Martin Holder
1   Klinikum Stuttgart, Olgahospital, Department of Pediatric Endocrinology and Diabetology, Germany
,
Thomas Kapellen
2   Department of Paediatrics and Adolescent Medicine, University Hospital, Leipzig, Germany
,
Ralph Ziegler
3   Practice for Paediatrics and Adolescent Medicine, Focus on Diabetology, Münster, Germany
,
Jutta Bürger-Büsing
4   Association of Diabetic Children and Adolescents, Diabetes Center, Kaiserslautern, Germany
,
Thomas Danne
5   Children’s and Youth Hospital Auf der Bult, Hannover, Germany
,
Axel Dost
6   Department of Paediatrics and Adolescent Medicine, University Hospital Jena, Germany
,
Reinhard W. Holl
7   Institute for Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Germany
,
Paul-Martin Holterhus
8   Department of General Paediatrics, University Hospital Schleswig-Holstein, Kiel Campus, Germany
,
Beate Karges
9   Endocrinology and Diabetology Section, University Hospital, RWTH Aachen University, Germany
,
Olga Kordonouri
5   Children’s and Youth Hospital Auf der Bult, Hannover, Germany
,
Karin Lange
10   Department of Medical Psychology, Hannover Medical School, Hannover, Germany
,
Susanne Müller
11   Practice for Nutrition Consultation, Ennepetal, Germany
,
Klemens Raile
12   Virchow Hospital, University Medicine, Berlin, Germany
,
Roland Schweizer
13   Department of Pediatrics and Adolescent Medicine, University Hospital Tübingen, Germany
,
Simone von Sengbusch
14   Department of Paediatrics and Adolescent Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Germany
,
Rainer Stachow
15   Sylt Specialist Hospital for Children and Adolescents, Westerland, Germany
,
Verena Wagner
16   Joint Practice for Paediatrics and Adolescent Medicine, Rostock, Germany
,
Susanna Wiegand
12   Virchow Hospital, University Medicine, Berlin, Germany
,
Andreas Neu
13   Department of Pediatrics and Adolescent Medicine, University Hospital Tübingen, Germany
› Author Affiliations
Preview
Abbreviations

μg microgram

ABCC8 gene localization for the sulfonylurea receptor 1

Abs antibodies

ACE angiotensin-converting enzyme

ACR albumin creatinine ratio

ADA American Diabetes Association

ADHD attention deficit/hyperactivity disorder

AER albumin excretion rate

AGA Working Group for Obesity/Arbeitsgemeinschaft für Adipositas

AGPDA Working Group for Paediatric Diabetology/Arbeitsgemeinschaft für Pädiatrische Diabetologie

AHCPR Agency for Health Care Policy and Research

AIHA autoimmune hemolytic anemia

ALT alanine transaminase=liver enzyme

APS Working Group for Paediatric Metabolic Disorders/Arbeitsgemeinschaft für Pädiatrische Stoffwechselstörungen

AT1 Angiotensin II receptor type 1

avg. average

AWMF German Association of the Scientific Medical Professional Societies/Arbeitsgemeinschaft der wissenschaftlichen medizinischen Fachgesellschaften

BABYDIAB German BabyDiab-Study (German baby diabetes study)

BAR Federal Working Group for Rehabilitation/Bundesarbeitsgemeinschaft für Rehabilitation

BdKJ Association of Diabetic Children and Adolescents/Bund diabetischer Kinder und Jugendlicher

BG blood glucose

BMI body mass index

BMI-SDS body mass index standard deviation score

BS blood sugar

BW body weight

c. a. condition after

C-peptide connecting peptide=part of proinsulin

CFRD cystic fibrosis-related diabetes

CGM continuous glucose monitoring

CK creatine kinase

CNS central nervous system

CSII continuous subcutaneous insulin injection=insulin pump

CT computer tomography

DAG German Obesity Society/Deutsche Adipositas Gesellschaft

DAISY Diabetes Autoimmunity Study of the Young (autoimmunity study for adolescents with diabetes)

DCC-Trial Diabetes Control and Complications Trial (study on the control and complications of diabetes)

DDG German Diabetes Society/Deutsche Diabetes Gesellschaft

DEND diabetes epilepsy and beurological delay (genetic syndrome with diabetes, epilepsy and neurological developmental disorder)

DENIS German Nicotinamide Intervention Study/Deutsche Nicotinamide-Intervention-Study

DEPS-R Diabetes Eating Problem Survey – Revised

DGE German Nutrition Society/Deutsche Gesellschaft für Ernährung

DGEM German Society for Nutritional Medicine/Deutsche Gesellschaft für Ernährungsmedizin

DGKJP German Society for Paediatric and Adolescent Psychiatry, Psychosomatics and Psychotherapy/Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie

diab. diabetic

diabetesDEDiabetes Germany

DIAMYD Diamyd® Study

DIPPDiabetes Prediction and Prevention Project

DKA diabetic ketoacidosis

dl decilitre

DNSG Diabetes And Nutrition Study Group

DPT-1 Diabetes Prevention Trial – Type 1

DPM Diabetes patient management (documentation system)

EASD European Association for the Study of Diabetes

EDIC-Trial Epidemiology of Diabetes Interventions and Complications Trial=Follow-up Study of the DCC Trial

EIF2AK3 Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 – gene locus for mutations leading to a genetic syndrome with diabetes

EC evidence class (methodological quality of a study according to criteria of evidence-based medicine)

ECG electrocardiogram

EMA European Medicines Agency

ENDIT European Nicotinamide Intervention Trial

ES educational support (therapeutic support in parenting)

esp. especially

ethn. ethnic

fam. familiar

FES family environment scale=scale for the evaluation of social characteristics and the environment of families

FOXP3 forkhead box P3 – gene locus for mutations leading to genetic syndromes with diabetes

FST-D family system therapy for patients with diabetes

fT3 free triiodothyronine

fT4 free thyroxine

g gram

GAD glutamate decarboxylase

GCK glucokinase

hhour

HbA1c glycated haemoglobin

HDL high-density lipoprotein

HHS hyperglycaemic hyperosmolar syndrome

HLA human leukocyte antigen

HNF hepatocyte nuclear factor

HTA health technology assessment=systematic assessment of medical technologies, procedures aids and organizational structures, in which medical services are provided

I.U. international unit(s)

i. m. intramuscular

IV intravenously

IA-2 tyrosine phosphatase IA-2 antibody

IAA insulin autoantibodies

ICAislet cell antibody

ICT intensified conventional therapy

IgA immunoglobulin A

IgG immunoglobulin G

INS insulin(s)

IPEX immunodysregulation polyendocrinopathy enteropathy X-linked syndrome

IPF-1 insulin promoter factor 1=gene locus with mutations leading to MODY-4 diabetes

IRMA intraretinal microvascular anomaly

ISPAD International Society for Paediatric and Adolescent Diabetes

ITP immune thrombocytopenic purpura

n/a not available

kcal kilocalories

KCNJ11inward-rectifier potassium ion channel, subfamily J, member 11

kgkilogram

Kir6.2major subunit of the ATP-sensitive K+ channel

KJHG child and youth welfare law

llitres

LDLlow-density lipoprotein

LGS low-glucose suspend

m2 square meters

max. maximum

mg milligram

micro microalbuminuria

min. minimum

MJ megajoules

ml millilitres

mm millimetres

mmHg millimetres of mercury=used to measure blood pressure

mmol millimole

mon month(s)

MODY maturity onset diabetes of the young (adult diabetes in adolescents)=monogenetic diabetes

MRI magnetic resonance imaging

n number

NaCl sodium chloride

NDM neonatal diabetes mellitus

NCV nerve conduction velocity

NPH neutral protamine Hagedorn

NYHA New York Heart Association classification system for the severity of heart failure

OGTT oral glucose tolerance test

p p-value/probability value – exceeding probability, statistical information

PAL physical activity level (value for measuring the daily physical activity expenditure)

Pat.patient(s)

pCO2 arterial partial pressure of carbon dioxide

pHpotentia hydrogenii (capacity of hydrogen)=negative logarithm of the hydrogen ion concentration/activity, measure for acidity of a medium

PGAs polyglandular autoimmune syndromes

PLGM predictive low glucose management

PNDM permanent neonatal diabetes mellitus

RCT randomized controlled trial

RR Riva Rocci=arterial blood pressure, measured according to the method of Riva Rocci

s. c. subcutaneous

SC standard care (standard treatment)

SEARCH search for diabetes in the youth study (studies for the identification of diabetes in children and adolescents)

SGB Social Code (Sozialgesetzbuch)

SIGN Scottish Intercollegiate Guidelines Network

sign. significant

SSRIselective serotonin reuptake inhibitor

STIKO Standing Vaccination Commission of the Federal Republic of Germany/Ständige Impfkommission der Bundesrepublik Deutschland

SaP sensor-augmented pump therapy

SUR 1 sulphonylurea receptor 1

SaT sensor-augmented insulin therapy

T3 triiodothyronine

T4 thyroxine

tTG tissue transglutaminase

Tg thyroglobulin

TNDM transient neonatal diabetes mellitus

TPO thyroid peroxidase

TSHR thyrotropin receptor

TRIGR Trial to Reduce IDDM in the Genetically at the Risk (Study on the reduction of diabetes mellitus by immunodeficiency for genetical risks)

TSH thyroid-stimulating hormone/thyrotropin

U unit

UK United Kingdom

vs. versus

WHO World Health Organization

Yyears

ZnT8 zinc transporter 8



Publication History

Article published online:
29 July 2022

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