Synthesis 2022; 54(05): 1287-1300
DOI: 10.1055/a-1681-3972
feature

Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides

Laura Köring
,
Nikolai A. Sitte
,
Jan Paradies
The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is gratefully acknowledged for financial support (PA 1562/18-1). The Verband der Chemischen Industrie (VCI) is acknowledged for Kekulé grants to L.K. and N.S.


Abstract

The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the developed chemistry is extended to the hydrogenation of polyamides and of trifluoroacetamides for the convenient introduction of trifluoroethyl groups into organic molecules.

Supporting Information



Publication History

Received: 03 September 2021

Accepted after revision: 28 October 2021

Publication Date:
28 October 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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