Novel Insight into the Mechanism of Metabolic Surgery Causing the
                    Diversity in Glycemic Status in Type 2 Diabetes

Mengxiao Zhou; Lijuan Wang; Lujin Zhou; Xiaotong Chang; Xiaobo Zhu

doi:10.1055/a-1708-3214

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2022; 130(07): 484-492
DOI: 10.1055/a-1708-3214

Article

Novel Insight into the Mechanism of Metabolic Surgery Causing the Diversity in Glycemic Status in Type 2 Diabetes

Mengxiao Zhou‡

¹Key Laboratory of Clinical Diagnostics, North University of Hebei, Zhangjiakou, China

²Department of Blood Transfusion, Forth Hospital of Shijiazhuang, Shijiazhuang, China

,

Lijuan Wang‡

³Department of Day Care Unit, Gansu Hospital of Traditional Chinese Medicine, Lanzhou, China

,

Lujin Zhou

¹Key Laboratory of Clinical Diagnostics, North University of Hebei, Zhangjiakou, China

,

Xiaotong Chang

¹Key Laboratory of Clinical Diagnostics, North University of Hebei, Zhangjiakou, China

,

Xiaobo Zhu

¹Key Laboratory of Clinical Diagnostics, North University of Hebei, Zhangjiakou, China

› Author Affiliations

Abstract

Metabolic surgery results in diverse glycemic status in patients with type 2 diabetes (T2D), including hyperglycemia without remission, significant amelioration of hyperglycemia with partial remission, complete restoration of euglycemia, or with prolonged remission, hyperglycemia recurrence in relapses after remission, or post-bariatric hypoglycemia. Unfortunately, it is not known how metabolic surgery leads to this diverse consequence. Here, we discuss the diversity of glycemic status associated with metabolic surgery and the potential mechanisms of T2D remission. We also highlight the relationship between the change in low-grade inflammation and T2D remission after metabolic surgery. We hypothesize that the level of inflammatory and anti-inflammatory cytokines controls the efficacy of metabolic surgery in patients with T2D. This hypothesis may provide further insight into the mechanism of the beneficial effects of metabolic surgery patients with T2D.

Key Words

Metabolic surgery - Type 2 Diabetes - Glycemic status - Low-grade inflammation

Full Text

References

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