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Exp Clin Endocrinol Diabetes 2022; 130(10): 678-686
DOI: 10.1055/a-1749-4909
Mini-Review

Leveraging Potential of Nanotherapeutics in Management of Diabetic Foot Ulcer

Supriya Pandey
1   Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India
,
Mohammad Shaif
1   Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India
,
Tarique M Ansari
1   Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India
,
Arshiya Shamim
1   Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India
,
Poonam Kushwaha
1   Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India
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Abstract

Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. DFUs are displayed as open sores or wounds located on the bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs are associated with significant morbidity and mortality and can subsequently lead to hospitalization and lower limb amputation if not recognized and treated on time. An immense challenge to conventional treatments is caused by the chronic nature of diabetic foot syndrome and it has led to the emergence of nanotechnology-based therapeutics. The greatest advantages of these nanotherapeutics are their unique biological, chemical, and physical properties. The present review highlights the augmentation of bacterial infections relating to delayed healing of DFUs and the potential of nanotherapeutics such as polymeric nanoparticles, metallic nanoparticles, siRNA-based nanoparticles, lipid nanoparticles, and nanofibers in accelerating wound healing in diabetic foot ulcers.

Key words

Nanotechnology - diabetes mellitus - diabetic foot ulcer - wound healing - pathophysiology - nanotherapeutics


Publication History

Received: 14 October 2021
Received: 10 January 2022

Accepted: 18 January 2022

Article published online:
03 March 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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