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Exp Clin Endocrinol Diabetes 2022; 130(08): 546-553
DOI: 10.1055/a-1785-3729
DOI: 10.1055/a-1785-3729
Article
Hyperuricemia Associated with Low Skeletal Muscle in the Middle-Aged and Elderly Population in China
Funding The research was supported by the National Key Basic Research Program of China (Grant No. 2012CB524906 to Gao X and Grant No. 2011CB504004 to Gao X), the Shanghai Municipal Health Bureau Foundation (Grant No.12GWZX0103 to Gao X), the Shanghai Municipal Science and Technology Major Project (2017SHZDZX01 to Gao X), the key basic research grants from Science and Technology Commission of Shanghai Municipality (grant number 16JC1400500 and 16411954800to Gao X).
Abstract
Background Previous studies have presented inconsistent results on the relationship between serum uric acid and skeletal muscle mass (SMM). We aimed to explore whether a higher serum uric acid level was associated with low SMM in the Chinese population.
Methods We performed a cross-sectional analysis of 6595 subjects aged 45 years or older. They were tested for fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, uric acid, blood urea nitrogen, creatinine, and estimated glomerular filtration rate. SMM was accessed by dual-energy x-ray absorptiometry using two approaches: weight-adjusted appendicular skeletal muscle mass (ASM)% and ASM/BMI (body mass index (kg/m2)). Low SMM was defined as a cut-off point of ASM/BMI<0.789 for men and<0.512 for women.
Results Compared with their normal group, patients with hyperuricemia had lower ASM% (29.33±2.33 vs 30.03±2.34 for males and 24.71±1.99 vs 25.19±2.07 for females, P<0.01) and ASM/BMI (0.83±0.10 vs 0.85±0.10 for male and 0.60±0.07 vs 0.62±0.07 for female), with a higher prevalence of the associated low SMM in both sexes (35.2 vs 26.5% for male and 10.5 vs 5.9% for female, P<0.01). Pearson analysis showed that ASM% and ASM/BMI were negatively correlated with SUA (male: ASM/BMI, r=−0.097, ASM%, r=−0.146; female: ASM/BMI, r=−0.151, ASM%, r=−0.157; all P<0.001). Logistic regression analysis showed a positive association of hyperuricemia with adjusted risk of low SMM association.
Conclusions In a middle-aged and elderly Chinese population, hyperuricemia is independently and positively associated with low SMM and can vary by age and gender.
Publication History
Received: 16 September 2021
Received: 06 January 2022
Accepted: 11 February 2022
Article published online:
24 May 2022
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