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DOI: 10.1055/a-1789-4896
Original Article

ASSOCIATIONS OF HAEMOSTATIC VARIABLES WITH CARDIOVASCULAR DISEASE AND TOTAL MORTALITY - THE GLASGOW MONICA STUDY

Haemostatics and CVD
Gordon Lowe
1   University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland
,
Sanne A.E. Peters
2   Imperial College London Faculty of Medicine, London, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN4957)
,
Ann Rumley
3   University of Glasgow, Glasgow, United Kingdom of Great Britain and Northern Ireland
,
Hugh Tunstall-Pedoe
4   University of Dundee Division of Medical Sciences, Dundee, United Kingdom of Great Britain and Northern Ireland (Ringgold ID: RIN85326)
,
Mark Woodward 
5   George Institute for Global Health, University of New South Wales, Sydney, Australia (Ringgold ID: RIN7800)
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The associations of plasma levels of haemostatic factors, other than fibrinogen, with risks of cardiovascular disease and all-cause mortality are not well defined. In two phases of the Glasgow MONICA Study, we assayed coagulation factors (VII, VIII, IX and von Willebrand factor, VWF), coagulation inhibitors (antithrombin, protein C, protein S), coagulation activation markers (prothrombin F1+2, thrombin-antithrombin [TAT] complexes, D-dimer), and the fibrinolytic factors tissue plasminogen activator antigen (t-PA) and plasminogen activator inhibitor (PAI-1). Over 15-20 years, we followed-up between 382 and 1123 men and women aged 30-74 years, without baseline CVD, for risks of CVD and mortality. Age and sex adjusted hazard ratios (HRs) for CVD (top third versus bottom third) were significant only for Factor VIII (1.30; 95% CI 1.06, 1.58) and Factor IX (1.18; 1.01, 1.39); these HRs were attenuated by further adjustment for CVD risk factors: 1.17; 0.94, 1.46, and 1.07; 0.92, 1.25, respectively. In contrast, Factor VIII, D-dimer and t-PA were strongly associated with mortality after full risk factor adjustment: respectively, 1.63 (1.35, 1.96), 2.34 (1.26; 4.35) and 2.81 (1.43, 5.54). Further studies, including meta-analyses, are required to assess the associations of these haemostatic factors with the risks of stroke and heart disease and causes of mortality.



Publication History

Received: 01 February 2022

Accepted: 28 February 2022

Accepted Manuscript online:
04 March 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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