Can a Short-term Daily Oral Administration of Propolis Improve Muscle
                    Fatigue and Recovery?

Yuma Tsuchiya; Naoya Hirata; Takashi Asama; Naomi Osakabe; Kosuke Hirata; Ryota Akagi

doi:10.1055/a-1808-6319

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2022; 43(10): 859-864
DOI: 10.1055/a-1808-6319

Physiology & Biochemistry

Can a Short-term Daily Oral Administration of Propolis Improve Muscle Fatigue and Recovery?

Authors

Yuma Tsuchiya

¹Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama-shi, Japan
Naoya Hirata

¹Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama-shi, Japan
Takashi Asama

²Institute for Bee Products and Health Science, R&D department, Yamada Bee Company Inc, Kagamino-cho, Japan
Naomi Osakabe

³College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama-shi, Japan
Kosuke Hirata

⁴Faculty of Sport Sciences, Waseda University, Tokorozawa-shi, Japan
Ryota Akagi

³College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama-shi, Japan

Abstract

This study investigated the effect of 1-week oral administration of propolis on muscle fatigue and recovery after performing a fatigue task (total 100 maximal voluntary concentric knee extension repetitions). In this placebo-controlled, double-blind study, 18 young men consumed a formulation with high Brazilian green propolis dose (H-BGP), a formulation with low Brazilian green propolis dose, or a placebo, for 1 week before performing the fatigue task (an interval between each intervention: 1–2 weeks). Maximal voluntary contraction torque, central fatigue (voluntary activation and root mean square values of the surface electromyography amplitude), and peripheral fatigue (potentiated triplet torque) were assessed before, immediately after, and 2 minutes after the fatigue task. Maximal voluntary contraction torque decreased immediately after the fatigue task in all conditions (P<0.001); however, it recovered from immediately after to 2 minutes after the fatigue task only in the H-BGP condition (P<0.001). Furthermore, there was a significant decrease in voluntary activation (P<0.001) and root mean square values of the surface electromyography amplitude (P≤0.035) only in the placebo condition. No significant difference was observed in the time-course change in potentiated triplet torque between the conditions. These results suggest that oral administration of propolis promotes muscle fatigue recovery by reducing central fatigue.

Key words

brazilian green propolis - knee extensors - concentric contraction - potentiated triplet torque - voluntary activation

Full Text

References

References
1 Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 2001; 81: 1725-1789
2 Kellmann M, Bertollo M, Bosquet L. et al. Recovery and performance in sport: consensus statement. Int J Sports Physiol Perform 2018; 13: 240-245
3 Braakhuis AJ, Hopkins WG. Impact of dietary antioxidants on sport performance: a review. Sports Med 2015; 45: 939-955
4 Johnston CS, Barkyoumb GM, Schumacher SS. Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vitamin C status: a randomized controlled trial. Nutrients 2014; 6: 2572-2583
5 Etheridge T, Philp A, Watt PW. A single protein meal increases recovery of muscle function following an acute eccentric exercise bout. Appl Physiol Nutr Metab 2008; 33: 483-488
6 Cruzat VF, Krause M, Newsholme P. Amino acid supplementation and impact on immune function in the context of exercise. J Int Soc Sports Nutr 2014; 11: 61
7 Bastos-Silva VJ, Melo AA, Lima-Silva AE. et al. Carbohydrate mouth rinse maintains muscle electromyographic activity and increases time to exhaustion during moderate but not high-intensity cycling exercise. Nutrients 2016; 8: 49
8 Braakhuis A. Evidence on the health benefits of supplemental propolis. Nutrients 2019; 11: 2705
9 Sforcin JM. Biological properties and therapeutic applications of propolis. Phytother Res 2016; 30: 894-905
10 Yesiltas B, Capanoglu E, Firatligil-Durmus E. et al. Investigating the in-vitro bioaccessibility of propolis and pollen using a simulated gastrointestinal digestion system. J Apic Res 2014; 53: 101-108
11 Beserra FP, Gushiken LFS, Hussni MF. et al. Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: a review on pharmacological aspects. Phytother Res 2020; 35: 2274-2286
12 Ferreira LF, Reid MB. Muscle-derived ROS and thiol regulation in muscle fatigue. J Appl Physiol (1985) 2008; 104: 853-860
13 Powers SK, Radak Z, Ji LL. Exercise-induced oxidative stress: past, present and future. J Physiol 2016; 594: 5081-5092
14 Braik A, Lahouel M, Merabet R. et al. Myocardial protection by propolis during prolonged hypothermic preservation. Cryobiology 2019; 88: 29-37
15 Egawa T, Tsuda S, Goto A. et al. Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice. Br J Nutr 2017; 117: 21-29
16 Egawa T, Ohno Y, Yokoyama S. et al. The protective effect of Brazilian propolis against glycation stress in mouse skeletal muscle. Foods 2019; 8: 439
17 Yamaga M, Tani H, Nishikawa M. et al. Pharmacokinetics and metabolism of cinnamic acid derivatives and flavonoids after oral administration of Brazilian green propolis in humans. Food Funct 2021; 12: 2520-2530
18 Harriss DJ, Macsween A Atkinson. Ethical standards in sport and exercise science research: 2020 update. 2019; 40: 813-817. Int J Sports Med 2019; 40: 813-817
19 Hirata K, Tanimoto H, Sato S. et al. Carbon dioxide hydrate as a recovery tool after fatigue of the plantar flexors. J Biomech 2020; 108: 109900
20 Johnson MA, Sharpe GR, Williams NC. et al. Locomotor muscle fatigue is not critically regulated after prior upper body exercise. J Appl Physiol (1985) 2015; 119: 840-850
21 Akagi R, Sato S, Yoshihara K. et al. Sex difference in fatigability of knee extensor muscles during sustained low-level contractions. Sci Rep 2019; 9: 16718
22 Akagi R, Hinks A, Power GA. Differential changes in muscle architecture and neuromuscular fatigability induced by isometric resistance training at short and long muscle-tendon unit lengths. J Appl Physiol (1985) 2020; 129: 173-184
23 Sidhu SK, Weavil JC, Mangum TS. et al. Group III/IV locomotor muscle afferents alter motor cortical and corticospinal excitability and promote central fatigue during cycling exercise. Clin Neurophysiol 2017; 128: 44-55
24 Amann M. Significance of Group III and IV muscle afferents for the endurance exercising human. Clin Exp Pharmacol Physiol 2012; 39: 831-835
25 Delliaux S, Brerro-Saby C, Steinberg JG. et al. Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats. Pflugers Arch 2009; 459: 143-150
26 Morris SB. Estimating effect sizes from pretest-posttest-control group designs. Organ Res Methods 2008; 11: 364-386
27 Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, MI: Lawrence Erlbaum Associates; 1988: 24-27
28 Mira J, Lapole T, Souron R. et al. Cortical voluntary activation testing methodology impacts central fatigue. Eur J Appl Physiol 2017; 117: 1845-1857