Idiopathische rekurrierende Perikarditis

ZUSAMMENFASSUNG

Die idiopathische rekurrierende Perikarditis (IRP) umfasst rezidivierende Perikarditis-Episoden, für die keine anderen Ursachen bzw. Auslöser gefunden werden können. Aufgrund ihres inflammatorischen Charakters (meist akute Schmerzattacken mit deutlich erhöhten serologischen Entzündungszeichen sowie gutem Ansprechen auf Colchicin und/oder Interleukin-1-Blockade) mit Rezidivneigung wird die Erkrankung auch als eigenständige autoinflammatorische Erkrankung angesehen. Darüber hinaus können vergleichbare Episoden auch bei anderen autoinflammatorischen Erkrankungen wie dem familiären Mittelmeerfieber (FMF) oder TNF-Rezeptor-assoziierten periodischen Syndrom (TRAPS) auftreten. Der Artikel gibt einen Überblick über die Klinik, Pathophysiologie und Therapie der IRP.

ABSTRACT

Idiopathic recurrent pericarditis (IRP) refers to episodes of recurrent pericarditis for which no other causes or triggers can be identified. Due to the inflammatory character (acute attacks of thoracic pain with increased serological inflammatory markers and a good response to colchicine and/or interleukin-1-blockade) with a tendency to recurrence, the disease is considered an autoinflammatory disease. In addition, comparable episodes can also be other autoinflammatory diseases such as familial Mediterranean fever (FMF) or TNF receptor-associated periodic syndrome (TRAPS). This article provides an overview of the clinic, pathophysiology, and therapy of IRP.

Schlüsselwörter

Autoinflammation - familiäres Mittelmeerfieber - TRAPS - IL-1-Blockade

Keywords

Autoinflammation - Familial Mediterranean Fever - TRAPS - IL-1-blockage

• Literatur

• 1 Krusche M, Schneider U, Ruffer N. [Pericarditis is inflammation of the pericardium, which rheumatologists should know]. Z Rheumatol 2021; 80: 54-64
• 2 Imazio M. et al Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J ehab 452 2021;
• 3 Imazio M. et al Good prognosis for pericarditis with and without myocardial involvement: results from a multicenter, prospective cohort study. Circulation 2013; 128: 42-49
• 4 Cremer PC. et al Complicated Pericarditis: Understanding Risk Factors and Pathophysiology to Inform Imaging and Treatment. J Am Coll Cardiol 2016; 68: 2311-2328
• 5 Imazio M. et al Colchicine for recurrent pericarditis (CORP): a randomized trial. Ann Intern Med 2011; 155: 409-414
• 6 Imazio M, Gaita F, LeWinter M. Evaluation and Treatment of Pericarditis: A Systematic Review. JAMA 2015; 314: 1498-1506
• 7 Permanyer-Miralda G, Sagristá-Sauleda J, Soler-Soler J. Primary acute pericardial disease: a prospective series of 231 consecutive patients. Am J Cardiol 1985; 56: 623-630
• 8 Maestroni S. et al Recurrent pericarditis: autoimmune or autoinflammatory?. Autoimmun Rev 2012; 12: 60-65
• 9 Ozen S. et al Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children. Ann Rheum Dis 2014; 73: 662-667
• 10 Peet CJ. et al Pericarditis and Autoinflammation: A Clinical and Genetic Analysis of Patients With Idiopathic Recurrent Pericarditis and Monogenic Autoinflammatory Diseases at a National Referral Center. J Am Heart Assoc 11: e024931 2022;
• 11 Lachmann HJ. et al The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry. Ann Rheum Dis 2014; 73: 2160-2167
• 12 Cantarini L, Lucherini OM, Baldari CT. et al Familial clustering of recurrent pericarditis may disclose tumour necrosis factor receptor-associated periodic syndrome. Clin Exp Rheumatol 2010; 28: 405-407
• 13 Cantarini L. et al Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. Clin Res Cardiol Off J Ger Card Soc 2012; 101: 525-531
• 14 Cantarini L. et al The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up. Semin. Arthritis Rheum 2014; 43: 818-823
• 15 Kontzias A. Idiopathic Recurrent Acute Pericarditis. In: Efthimiou P, ed. Auto-Inflammatory Syndromes: Pathophysiology, Diagnosis, and Management. Springer International Publishing 2019
• 16 Ristić AD, Pankuweit S, Maksimović R. et al Pericardial cytokines in neoplastic, autoreactive, and viral pericarditis. Heart Fail Rev 2013; 18: 345-353
• 17 Lazaros G. et al The role of the immunogenetic background in the development and recurrence of acute idiopathic pericarditis. Cardiology 2011; 118: 55-62
• 18 Adler Y. et al 2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC) Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2015; 36: 2921-2964
• 19 Boyadzhieva Z, Ruffer N, Krusche M. Colchicin: altes Medikament mit neuem Nutzen: Einsatz in der Rheumatologie und darüber hinaus. Z Rheumatol 2021; 80: 647-657
• 20 Imazio M. et al Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial. Circulation 2005; 112: 2012-2016
• 21 Imazio M. et al A randomized trial of colchicine for acute pericarditis. N Engl J Med 2013; 369: 1522-1528
• 22 Imazio M. et al Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial. Lancet Lond Engl 2014; 383: 2232-2237
• 23 Vianello F. et al Azathioprine in isolated recurrent pericarditis: a single centre experience. Int J Cardiol 2011; 147: 477-478
• 24 Imazio M. et al Intravenous human immunoglobulins for refractory recurrent pericarditis: a systematic review of all published cases. J Cardiovasc Med 2016; 17: 263-269
• 25 Lo Presti S. et al Emerging Therapies for Recurrent Pericarditis: Interleukin-1 inhibitors. J Am Heart Assoc 2021; 10: e021685
• 26 Imazio M. et al Anakinra for corticosteroid-dependent and colchicine-resistant pericarditis: The IRAP (International Registry of Anakinra for Pericarditis) study. Eur J. Prev Cardiol 2020; 27: 956-964
• 27 Klein A. et al Rilonacept in recurrent pericarditis: first efficacy and safety data from an ongoing phase 2 pilot clinical trial. J Am Coll Cardiol 2019; 73: 1261
• 28 Gillaspie EA. et al A 20-year experience with isolated pericardiectomy: Analysis of indications and outcomes. J Thorac Cardiovasc Surg 2016; 152: 448-458