Zeitschrift für Orthomolekulare Medizin 2022; 20(03): 20-27
DOI: 10.1055/a-1914-0993
Wissen

Kardioprotektive und pleiotrope Effekte von Coenzym Q10

Uwe Gröber
,
Daniel Schniertshauer
,
Hans-Peter Friedrichsen
,
Jörg Bergemann

Zusammenfassung

Coenzym Q10 ist ein ubiquitäres endogenes Chinon-Derivat, das in den biologischen Membranen der Körperzellen und als antioxidative Komponente in zirkulierenden Lipoproteinen vorkommt. Das Vitaminoid spielt eine wichtige Rolle bei der Energieproduktion in den Mitochondrien. Eine unzureichende Versorgung mit Coenzym Q10, wie sie bei Erkrankungen mit oxidativem Stress häufig vorkommt, ist mit einer allgemeinen Abnahme der psychischen und physischen Leistungsfähigkeit verbunden. Coenzym Q10 und seine reduzierte Form Ubiquinol haben sich mittlerweile in der Prävention und Therapie einer Vielzahl von Erkrankungen klinisch bewährt.



Publication History

Article published online:
05 October 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Pallotti F, Bergamini C, Lamperti C. et al. The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions. IJMS 2022; 23: 128
  • 2 Crane FL.. Biochemical functions of coenzyme Q10. J Am Coll Nutr 2001; 20: 591-598
  • 3 Bentinger M, Tekle M, Dallner G.. Coenzyme Q-biosynthesis and functions. Biochem Biophys Res Commun 2010; 396: 74-79
  • 4 Christiakov DA, Shkurat T, Melnichenko A. et al. The role of mitochondrial dysfunction in cardiovascular disease: a brief review. Ann Med 2018; 50: 121-127
  • 5 Baris OR, Ederer S, Neuhaus JFG. Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging. Cell Metab 2015; 21: 667-677
  • 6 Zahra AAD, Otandault A, Tanos R. et al. Blood contains circulating cell-free respiratory competent mitochondria. FASEB J 2020; 34: 3616-3630
  • 7 Pravst I, Rodriguez Aguilera JC, Cortes Rodriguez AB. et al. Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients 2020; 12: 784
  • 8 Estornell E, Fato R, Castelluccio C. et al. Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria. FEBS Lett 1992; 311: 107-109
  • 9 Littarru GP, Tiano L.. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007; 37: 31-37
  • 10 Schniertshauer D, Muller S, Mayr T. et al. Accelerated Regeneration of ATP Level after Irradiation in Human Skin Fibroblasts by Coenzyme Q10. Photochem Photobiol 2016; 92: 488-494
  • 11 Schniertshauer D, Gebhard D, Bergemann J.. Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10. J Aging Res 2018; 6354680
  • 12 Schniertshauer D, Bergemann J.. Pleiotrope Effekte von Coenzym Q10 in der Mitochondrialen Medizin. OM & Ernährung 2022; SH 24: 46-55
  • 13 Schniertshauer D, Gebhard D, van Beek H. et al. The activity of the DNA repair enzyme hOGG1 can be directly modulated by ubiquinol. DNA Repair (Amst) 2020; 87: 102784
  • 14 Bentinger M, Brismar K, Dallner G.. The antioxidant role of coenzyme Q. Mitochondrion Suppl 2007; 7: S41-S50
  • 15 Nordman T, Xia L, Bjorkhem-Bergman L. et al. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. Biofactors 2003; 18: 45-50
  • 16 Alehagen U, Johansson P, Björnstedt M. et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013; 167: 1860-1866
  • 17 Ajehagen U, Alexander J, Aaseth J.. Supplementation with Selenium and Coenzyme Q10 Reduces Cardiovascular Mortality in Elderly with Low Selenium Status. A Secondary Analysis of a Randomised Clinical Trial. PLos One 2016; 11: e0157541 DOI: 10.1371/journal.pone.0157541.
  • 18 Su YH, Lee YL, Chen SF. et al. Essential role of β-human 8-oxoguanine DNA glycosylase 1 in mitochondrial oxidative DNA repair. Environ Mol Mutagen 2013; 54: 54-64
  • 19 Edeas M.. Strategies to target mitochondria and oxidative stress by antioxidants: key points and perspectives. Pharm Res 2011; 28: 2771-2779
  • 20 Perumal SS, Shanthi P, Sachdanandam P.. Augmented efficacy of tamoxifen in rat breast tumorigenesis when gavaged along with riboflavin, niacin, and CoQ10: effects on lipid peroxidation and antioxidants in mitochondria. Chem Biol Interact 2005; 152: 49-58
  • 21 Echtay KS, Winkler E, Klingenberg M.. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 2000; 408: 609-613
  • 22 Echtay KS, Winkler E, Frischmuth K, Klingenberg M.. Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci USA 2001; 98: 1416-1421
  • 23 Nedergaard J, Ricquier D, Kozak LP.. Uncoupling proteins: current status and therapeutic prospects. EMBO Rep 2005; 6: 917-921
  • 24 Sue-Ling CB, Abel WM, Sue-Ling K. Coenzyme Q10 as Adjunctive Therapy for Cardiovascular Disease and Hypertension: A Systematic Review. J Nutr 2022; 152: 1666-1674
  • 25 Gröber U, Kisters K, Schmidt J.. Important drug-micronutrient interactions: A selection for clinical practice. Crit Rev Food Sci Nutr 2020; 60: 257-275
  • 26 Stroes ES, Thompson PD, Corsini A. et al. Statin-associated muscle symptoms: impact on statin therapy--European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J 2015; 36: 1012-1022
  • 27 Banach M, Serban C, Ursoniu S. et al. Statin therapy and plasma coenzyme Q10 concentrations- A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res 2015; 99: 329-336
  • 28 Qu H, Mang YY, Chai H. et al. The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res 2018; 23: 57
  • 29 Qu H, Guo M, Chai H. et al. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc 2018; 7: e009835
  • 30 Perez-Sanchez C, Aguirre MA, Ruiz-Limon P. et al. Ubiquinol effects on antiphospholipid syndrome prothrombotic profile: a randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2017; 37: 1923-1932
  • 31 Evans M, Baisley J, Barss S, Guthrie N.. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Funct Foods 2009; 1: 65-73
  • 32 Yamashita S, Yamamoto Y.. Simultaneous detection of ubiquinol and ubiquinone human plasma as a marker of oxidative stress. Ann Biochem 1997; 250: 66-73
  • 33 Samimi F, Baazm M, Eftekhar E.. Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways. Res Pharm Sci 2019; 14: 524-533
  • 34 Hernandez-Camacho JD, Bernier M, Lopez-Lluch G. et al. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol 2018; 9: 44 DOI: 10.3389/fphys.2018.00044.