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Klin Monbl Augenheilkd 2023; 240(02): 163-168
DOI: 10.1055/a-1942-2007
Klinische Studie

Effect of Intense Pulsed Light to Mitigate Meibomian Gland Dysfunction for Dry Eye Disease

Wirkung von intensivem gepulstem Licht zur Linderung der Meibom-Drüsen-Dysfunktion für das Trockene-Auge-Syndrom
Abhishek Suwal‡
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
,
Jilong Hao‡
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
,
Xiufen Liu‡
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
,
Dandan Zhou‡
2   Department of Radiology, The First Hospital of Jilin University, Changchun, China
,
Zhifang Jia
3   Division of Clinical Research, The First Hospital of Jilin University, Changchun, China
,
Hongwei Liu
4   Ophthalmology, Jiamusi University First Affiliated Hospital, Jiamusi, China
,
Yu Ren
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
,
Fei Shao
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
,
Chengwei Lu 
1   Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China
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Abstract

Background This retrospective study aimed to evaluate the effect of intense pulsed light treatment (IPL) combined with meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD) related dry eye disease (DED) for the first time in Northeast China.

Methods Thirty-one MGD-related dry eye patients were managed by IPL-MGX from October to December 2019 in The First Hospital of Jilin University. Those patients had single IPL-MGX treatment with one follow-up visit, and no topical eye drops used were included in the study. General checkup and data collection helped in determining the age, sex, diagnosis, status of the MG, first noninvasive tear break-up time (1st NIBUT), average NIBUT, the height of tear film, and additional medical history.

Results There was an improvement in the function of the meibomian gland (MG), with a significant decrease in the MG dropouts in the upper eyelid (Rt eye, p = 0.0047; Lt eye, p = 0.0158) and lower eyelid (Rt eye, p = 0.0017; Lt eye, p = 0.0027) plus the average NIBUT (Rt eye, p = 0.0264) also showed improvement after the IPL-MGX treatment. Though no significant difference was reached with the average NIBUT of the Lt eye (p = 0.5256) and the NIBUT grade (Rt eye, p = 0.0578; Lt eye, p = 0.0588), there was an increased duration of the average NIBUT and improved NIBUT grading. The negative results may be because of the maximum severity of DED and the limited treatment times.

Conclusions The result suggests that IPL-MGX was effective in treating MGD-related DED.

Zusammenfassung

Hintergrund Diese retrospektive Studie zielt darauf ab, die Wirkung einer Behandlung mit intensiv gepulstem Licht (IPL) in Kombination mit der Meibom-Drüsen-Expression (MGX) bei der Behandlung der Meibom-Drüsen-Dysfunktion (MGD) im Zusammenhang mit dem Trockenen Auge (DED) zum ersten Mal in Nordostchina zu bewerten.

Methoden 31 Patienten mit Trockenem Auge im Zusammenhang mit MGD wurden von Oktober bis Dezember 2019 im Ersten Krankenhaus der Jilin-Universität mit IPL-MGX behandelt. Diese Patienten erhielten eine einzige IPL-MGX-Behandlung mit einem Folgebesuch, und es wurden keine topischen Augentropfen in die Studie aufgenommen. Die allgemeine Untersuchung und Datenerfassung half bei der Bestimmung von Alter, Geschlecht, Diagnose, Status der MG, Zeit der ersten nicht invasiven Tränenfilmunterbrechung (1. NIBUT), durchschnittlicher NIBUT, Höhe des Tränenfilms und zusätzlicher Krankengeschichte.

Ergebnisse Es gab eine Verbesserung der Funktion der Meibom-Drüse (MG) mit einer signifikanten Abnahme der MG-Aussetzer im oberen Augenlid (rechtes Auge, p = 0,0047; linkes Auge, p = 0,0158) und im unteren Augenlid (rechtes Auge, p = 0,0017; linkes Auge, p = 0,0027) plus die durchschnittliche NIBUT (rechtes Auge, p = 0,0264) zeigte ebenfalls eine Verbesserung nach der IPL-MGX-Behandlung. Obwohl kein signifikanter Unterschied zwischen der durchschnittlichen NIBUT auf dem linken Auge (p = 0,5256) und dem NIBUT-Grad (rechtes Auge, p = 0,0578; linkes Auge, p = 0,0588) erreicht wurde, gibt es eine längere Dauer der durchschnittlichen NIBUT und eine verbesserte NIBUT-Einstufung. Die negativen Ergebnisse können auf den maximalen Schweregrad der KCS und die begrenzten Behandlungszeiten zurückzuführen sein.

Schlussfolgerungen Das Ergebnis legt nahe, dass IPL-MGX bei der Behandlung von MGD-bedingter KCS wirksam war.

Key words

dry eye disease (DED) - meibomian gland dysfunction (MGD) - noninvasive tear break-up time (NIBUT) - intense pulsed light (IPL)

Schlüsselwörter

Trockenes Auge (DED) - Meibom-Drüsen-Dysfunktion (MGD) - nicht invasive Tränenfilmaufbruchzeit (NIBUT) - intense pulsed light (IPL)


Publikationsverlauf

Eingereicht: 23. Mai 2022

Angenommen: 10. September 2022

Accepted Manuscript online:
13. September 2022

Artikel online veröffentlicht:
27. November 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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