CC BY-NC-ND 4.0 · Laryngorhinootologie 2023; 102(S 01): S67-S92
DOI: 10.1055/a-1957-3267
Referat

Olfactory Function and Olfactory Disorders

Article in several languages: deutsch | English
T Hummel
1   Interdisziplinäres Zentrum Riechen und Schmecken, HNO Klinik, TU Dresden,
,
N Power Guerra
2   Rudolf-Zenker-Institut für Experimentelle Chirurgie, Medizinische Universität Rostock, Rostock,
,
N Gunder
3   Universitäts-HNO Klinik Dresden, Dresden,
,
A Hähner
1   Interdisziplinäres Zentrum Riechen und Schmecken, HNO Klinik, TU Dresden,
,
S Menzel
1   Interdisziplinäres Zentrum Riechen und Schmecken, HNO Klinik, TU Dresden,
› Author Affiliations

Abstract

The sense of smell is important. This became especially clear to patients with infection-related olfactory loss during the SARS-CoV-2 pandemic. We react, for example, to the body odors of other humans. The sense of smell warns us of danger, and it allows us to perceive flavors when eating and drinking. In essence, this means quality of life. Therefore, anosmia must be taken seriously. Although olfactory receptor neurons are characterized by regenerative capacity, anosmia is relatively common with about 5 % of anosmic people in the general population. Olfactory disorders are classified according to their causes (e. g., infections of the upper respiratory tract, traumatic brain injury, chronic rhinosinusitis, age) with the resulting different therapeutic options and prognoses. Thorough history taking is therefore important. A wide variety of tools are available for diagnosis, ranging from short screening tests and detailed multidimensional test procedures to electrophysiological and imaging methods. Thus, quantitative olfactory disorders are easily assessable and traceable. For qualitative olfactory disorders such as parosmia, however, no objectifying diagnostic procedures are currently available. Therapeutic options for olfactory disorders are limited. Nevertheless, there are effective options consisting of olfactory training as well as various additive drug therapies. The consultation and the competent discussion with the patients are of major importance.



Publication History

Article published online:
02 May 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • Literatur

  • 1 Pellegrino R, Mainland JD, Kelly CE, Parker JK, Hummel T.. Prevalence and correlates of parosmia and phantosmia among smell disorders. Chemical senses 2021; 46
  • 2 Zucco GM, Doty RL.. Multiple Chemical Sensitivity. Brain sciences 2022; 12: 46
  • 3 Eis D, Helm D, Mühlinghaus T, Birkner N, Dietel A, Eikmann T. et al. The German Multicentre Study on Multiple Chemical Sensitivity (MCS). International journal of hygiene and environmental health 2008; 211: 658-681
  • 4 Tan BKJ, Han R, Zhao JJ, Tan NKW, Quah ESH, Tan CJ-W. et al. Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves. BMJ 2022; e069503-e069503
  • 5 H Hoffman HJ, Ishii EK, MacTurk RH.. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci 1998; 855: 716-722
  • 6 Lee WH, Wee JH, Kim D-K, Rhee C-S, Lee CH, Ahn S. et al. Prevalence of subjective olfactory dysfunction and its risk factors: korean national health and nutrition examination survey. PLOS ONE 2013; 8: e62725
  • 7 Hwang S-H, Kang J-M, Seo J-H, Han K, Joo Y-H.. Gender Difference in the Epidemiological Association between Metabolic Syndrome and Olfactory Dysfunction: The Korea National Health and Nutrition Examination Survey. PLOS ONE 2016; 11: e0148813
  • 8 Bhattacharyya N, Kepnes LJ.. Contemporary assessment of the prevalence of smell and taste problems in adults. The Laryngoscope 2015; 125: 1102-1106
  • 9 Rawal S, Hoffman HJ, Bainbridge KE, Huedo-Medina TB, Duffy VB.. Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES). Chemical senses 2016; 41: 69-76
  • 10 Huang Z, Huang S, Cong H, Li Z, Li J, Keller KL. et al. Smell and Taste Dysfunction Is Associated with Higher Serum Total Cholesterol Concentrations in Chinese Adults. The. Journal of Nutrition 2017; 147: 1546-1551
  • 11 Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A. et al. Chronic rhinosinusitis in Europe – an underestimated disease. A GA²LEN study. Allergy 2011; 66: 1216-1223
  • 12 Hirsch AG, Stewart WF, Sundaresan AS, Young AJ, Kennedy TL, Scott Greene J. et al. Nasal and sinus symptoms and chronic rhinosinusitis in a population-based sample. Allergy 2017; 72: 274-281
  • 13 Schulz M, Mangiapane S, Scherer M, Karagiannidis C, Czihal T.. Post-Acute Sequelae of SARS-CoV-2 Infection. Deutsches Arzteblatt international 2022; 119: 177-178
  • 14 Landis BN, Konnerth CG, Hummel T.. A study on the frequency of olfactory dysfunction. The Laryngoscope 2004; 114: 1764-1769
  • 15 Brämerson A, Johansson L, Ek L, Nordin S, Bende M.. Prevalence of olfactory dysfunction: the skövde population-based study. The Laryngoscope 2004; 114: 733-737
  • 16 Vennemann MM, Hummel T, Berger K.. The association between smoking and smell and taste impairment in the general population. Journal of neurology 2008; 255: 1121-1126
  • 17 Nordin S, Brämerson A, Bende M.. Prevalence of self-reported poor odor detection sensitivity: the Skövde population-based study. Acta oto-laryngologica 2004; 124: 1171-1173
  • 18 Hinz A, Luck T, Riedel-Heller SG, Herzberg PY, Rolffs C, Wirkner K. et al. Olfactory dysfunction: properties of the Sniffin’ Sticks Screening 12 test and associations with quality of life. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2019; 276: 389-395
  • 19 Seubert J, Laukka EJ, Rizzuto D, Hummel T, Fratiglioni L, Bäckman L. et al. Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study. The journals of gerontology. Series A, Biological sciences and medical sciences 2017; 72: 1072-1079
  • 20 Ross GW, Petrovitch H, Abbott RD, Tanner CM, Popper J, Masaki K. et al. Association of olfactory dysfunction with risk for future Parkinson’s disease. Annals of neurology 2008; 63: 167-173
  • 21 Boesveldt S, Lindau ST, McClintock MK, Hummel T, Lundstrom JN, Lindstrom JN.. Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology 2011; 49: 324-330
  • 22 Kern DW, Wroblewski KE, Schumm LP, Pinto JM, Chen RC, McClintock MK.. Olfactory function in Wave 2 of the National Social Life, Health, and Aging Project. The journals of gerontology. Series B, Psychological sciences and social sciences 2014; 69 Suppl 2 S134-43
  • 23 Pinto JM, Schumm LP, Wroblewski KE, Kern DW, McClintock MK.. Racial disparities in olfactory loss among older adults in the United States. The journals of gerontology. Series A, Biological sciences and medical sciences 2014; 69: 323-329
  • 24 Devanand DP, Lee S, Manly J, Andrews H, Schupf N, Masurkar A. et al. Olfactory identification deficits and increased mortality in the community. Annals of neurology 2015; 78: 401-411
  • 25 Liu G, Zong G, Doty RL, Sun Q.. Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study. BMJ open 2016; 6: e013246
  • 26 Karpa MJ, Gopinath B, Rochtchina E, Jie JW, Cumming RG, Sue CM. et al. Prevalence and neurodegenerative or other associations with olfactory impairment in an older community. Journal of aging and health 2010; 22: 154-168
  • 27 Shu C-H, Hummel T, Lee P-L, Chiu C-H, Lin S-H, Yuan B-C.. The proportion of self-rated olfactory dysfunction does not change across the life span. American journal of rhinology & allergy 2009; 23: 413-416
  • 28 Mullol J, Alobid I, Mariño-Sánchez F, Quintó L, Haro de J, Bernal-Sprekelsen M. et al. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ open 2012; 2
  • 29 Murphy C, Schubert CR, Cruickshanks KJ, Klein BEK, Klein R, Nondahl DM.. Prevalence of olfactory impairment in older adults. JAMA 2002; 288: 2307-2312
  • 30 Desiato VM, Levy DA, Byun YJ, Nguyen SA, Soler ZM, Schlosser RJ.. The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis. American journal of rhinology & allergy 2021; 35: 195-205
  • 31 Bushdid C, Magnasco MO, Vosshall LB, Keller A.. Humans can discriminate more than 1 trillion olfactory stimuli. Science 2014; 343: 1370-1372
  • 32 Mayhew EJ, Arayata CJ, Gerkin RC, Lee BK, Magill JM, Snyder LL. et al. Transport features predict if a molecule is odorous. PROC. NAT. ACAD. OF SCI. (U.S.A.) 2022; 119 e2116576119
  • 33 Manzini I, Schild D, Di Natale C.. Principles of odor coding in vertebrates and artificial chemosensory systems. Physiological reviews 2022; 102: 61-154
  • 34 Fitzek M, Patel PK, Solomon PD, Lin B, Hummel T, Schwob JE. et al. Integrated age-related immunohistological changes occur in human olfactory epithelium and olfactory bulb. Journal of Comparative Neurology 2022; 530: 2154-2175
  • 35 Holbrook EH, Wu E, Curry WT, Lin DT, Schwob JE.. Immunohistochemical characterization of human olfactory tissue. The Laryngoscope 2011; 121: 1687-1701
  • 36 Féron F, Perry C, McGrath JJ, Mackay-Sim A.. New techniques for biopsy and culture of human olfactory epithelial neurons. Archives of otolaryngology – head & neck surgery 1998; 124: 861-866
  • 37 Lang J.. Clinical anatomy of the nose, nasal cavity, and paranasal sinuses. Stuttgart, New York, New York: Thieme; Thieme Medical Publishers; 1989
  • 38 Leopold DA, Hummel T, Schwob JE, Hong SC, Knecht M, Kobal G.. Anterior distribution of human olfactory epithelium. The Laryngoscope 2000; 110: 417-421
  • 39 E. A. Read. A Contribution to the Knowledge of the Olfactory Apparatus in Dog, Cat and Man. Am. J. Anat. 8: 17-47
  • 40 v. Brunn A.. Beiträge zur mikroskopischen Anatomie der menschlichen Nasenhöhle. Archiv f. mikrosk. Anatomie 1892; 39: 632-651
  • 41 Buck L, Axel R.. A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell 1991; 65: 175-187
  • 42 Dale Purves, George J Augustine, David Fitzpatrick, Lawrence C Katz, Anthony-Samuel LaMantia, James O McNamara, et al. The Transduction of Olfactory Signals. In: Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia A-S, McNamara JO, et al. (eds). Neuroscience. 2nd editionSinauer Associates; 2001
  • 43 Gilad Y, Bustamante CD, Lancet D, Pääbo S.. Natural selection on the olfactory receptor gene family in humans and chimpanzees. American journal of human genetics 2003; 73: 489-501
  • 44 Verbeurgt C, Wilkin F, Tarabichi M, Gregoire F, Dumont JE, Chatelain P.. Profiling of olfactory receptor gene expression in whole human olfactory mucosa. PloS one 2014; 9: e96333
  • 45 Dunkel A, Steinhaus M, Kotthoff M, Nowak B, Krautwurst D, Schieberle P. et al. Nature’s chemical signatures in human olfaction: a foodborne perspective for future biotechnology. Angewandte Chemie (International ed. in English) 2014; 53: 7124-7143
  • 46 Ressler KJ, Sullivan SL, Buck LB.. A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 1993; 73: 597-609
  • 47 Mombaerts P.. Odorant receptor gene choice in olfactory sensory neurons: the one receptor-one neuron hypothesis revisited. Current opinion in neurobiology 2004; 14: 31-36
  • 48 Axel R.. The molecular logic of smell. Scientific American 1995; 273: 154-159
  • 49 Firestein S.. How the olfactory system makes sense of scents. Nature 2001; 413: 211-218
  • 50 Holley A, Duchamp A, Revial MF, Juge A.. Qualitative and quantitative discrimination in the frog olfactory receptors: analysis from electrophysiological data. Annals of the New York Academy of Sciences 1974; 237: 102-114
  • 51 Kurian SM, Naressi RG, Manoel D, Barwich A-S, Malnic B, Saraiva LR.. Odor coding in the mammalian olfactory epithelium. Cell Tissue Res 2021; 383: 445-456
  • 52 Horowitz LF, Saraiva LR, Kuang D, Yoon K, Buck LB.. Olfactory receptor patterning in a higher primate. The Journal of neuroscience: the official journal of the Society for Neuroscience 2014; 34: 12241-12252
  • 53 Liberles SD, Buck LB.. A second class of chemosensory receptors in the olfactory epithelium. Nature 2006; 442: 645-650
  • 54 Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J. et al. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLOS ONE 2013; 8: e54950
  • 55 Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S. et al. Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nature neuroscience 2020; 23: 323-326
  • 56 Brann JH, Firestein SJ.. A lifetime of neurogenesis in the olfactory system. Front. Neurosci. 2014; 8: 182
  • 57 Graziadei P, Karlan MS, Monti GA, Bernstein JJ.. Neurogenesis of sensory neurons in the primate olfactory system after section of the fila olfactoria. Brain research 1980; 186: 289-300
  • 58 Fjaeldstad A, Fernandes HM, van Hartevelt TJ, Gleesborg C, Møller A, Ovesen T. et al. Brain fingerprints of olfaction: a novel structural method for assessing olfactory cortical networks in health and disease. Sci Rep 2017; 7: 42534
  • 59 Hummel T, Welge-Lussen A.. Taste and smell: An update: 33 figures, 1 in color, and 12 tables, 2006, Vol 63. Basel: Karger; 2006
  • 60 Frasnelli J, Manescu S.. The Intranasal Trigeminal System. In: Springer Handbook of Odor. Springer; Cham: 2017: 113-114
  • 61 Hummel T, Frasnelli J.. Chapter 8 – The intranasal trigeminal system. In: Doty RL (ed). Handbook of Clinical Neurology: Smell and Taste. Elsevier; 2019: 119-134
  • 62 Daiber P, Genovese F, Schriever VA, Hummel T, Möhrlen F, Frings S.. Neuropeptide receptors provide a signalling pathway for trigeminal modulation of olfactory transduction. The European journal of neuroscience 2013; 37: 572-582
  • 63 Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry L.. Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans. Physiology & behavior 1978; 20: 175-185
  • 64 Hummel T, Iannilli E, Frasnelli J, Boyle J, Gerber J.. Central processing of trigeminal activation in humans. Annals of the New York Academy of Sciences 2009; 1170: 190-195
  • 65 Mihara S, Shibamoto T.. The role of flavor and fragrance chemicals in TRPA1 (transient receptor potential cation channel, member A1) activity associated with allergies. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology 2015; 11: 11
  • 66 Konstantinidis I, Tsakiropoulou E, Chatziavramidis A, Ikonomidis C, Markou K.. Intranasal trigeminal function in patients with empty nose syndrome. The Laryngoscope 2017; 127: 1263-1267
  • 67 Li C, Farag AA, Maza G, McGhee S, Ciccone MA, Deshpande B. et al. Investigation of the abnormal nasal aerodynamics and trigeminal functions among empty nose syndrome patients. International forum of allergy & rhinology 2018; 8: 444-452
  • 68 Scheibe M, Schulze S, Mueller CA, Schuster B, Hummel T.. Intranasal trigeminal sensitivity: measurements before and after nasal surgery. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2014; 271: 87-92
  • 69 Zhao K, Jiang J, Blacker K, Lyman B, Dalton P, Cowart BJ. et al. Regional peak mucosal cooling predicts the perception of nasal patency. The Laryngoscope 2014; 124: 589-595
  • 70 Delank KW, Fechner G.. Zur Pathophysiologie der posttraumatischen Riechstörungen. Laryngol. Rhinol. Otol 1996; 75: 154-159
  • 71 Lötsch J, Daiker H, Hähner A, Ultsch A, Hummel T.. Drug-target based cross-sectional analysis of olfactory drug effects. Eur J Clin Pharmacol 2016; 71: 461-471
  • 72 Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C. et al. Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis. Chemical senses 2020; 45: 865-874
  • 73 Bartheld CS, von Hagen MM, Butowt R.. Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences. ACS Chem. Neurosci 2020; 19: 2944-2961
  • 74 Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T.. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2020; 163: 3-11
  • 75 Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L. et al. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 2020; 71: 889-890
  • 76 Lechien JR, Michel J, Radulesco T, Chiesa-Estomba CM, Vaira LA, Riu Gde. et al. Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report. The Laryngoscope 2020; 130: 2526-2531
  • 77 Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C. et al. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA 2020; 323: 2089-2090
  • 78 Niklassen AS, Draf J, Huart C, Hintschich C, Bocksberger S, Trecca EMC. et al. COVID-19: Recovery from chemosensory dysfunction. A multicentre study on smell and taste. The Laryngoscope. 2021
  • 79 Borsetto D, Hopkins C, Philips V, Obholzer R, Tirelli G, Polesel J. et al. Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients. Rhinology 2020; 58: 430-436
  • 80 Boscolo-Rizzo P, Tirelli G, Meloni P, Hopkins C, Madeddu G, Vito Ade. et al. Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant. International forum of allergy & rhinology 2022; 12: 1273-1281
  • 81 Hintschich CA, Vielsmeier V, Bohr C, Hagemann J, Klimek L.. Prevalence of acute olfactory dysfunction differs between variants of SARS-CoV-2-results from chemosensitive testing in wild type, VOC alpha (B.1.1.7) and VOC delta (B.1617.2). Eur Arch Otorhinolaryngol 2022; 279: 5445-5447
  • 82 Dehgani-Mobaraki P, Patel Z, Zaidi AK, Giannandrea D, Hopkins C.. The Omicron variant of SARS-CoV-2 and its effect on the olfactory system. International forum of allergy & rhinology. 2022
  • 83 Gane SB, Kelly C, Hopkins C.. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?. Rhinology 2020; 58: 299-301
  • 84 Hopkins C, Surda P, Kumar N.. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 2020; 58: 295-298
  • 85 Haehner A, Draf J, Dräger S, With K, de Hummel T.. Predictive Value of Sudden Olfactory Loss in the Diagnosis of COVID-19. ORL J Otorhinolaryngol Relat Spec 2020; 82: 175-180
  • 86 Huart C, Philpott C, Konstantinidis I, Altundag A, Whitcroft KL, Trecca EMC. et al. Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology 2020; 58: 623-625
  • 87 Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ. et al. More than smell – COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical senses 2020; 45: 609-622
  • 88 Duyan M, Ozturan IU, Altas M.. Delayed Parosmia Following SARS-CoV-2 Infection: a Rare Late Complication of COVID-19. SN comprehensive clinical medicine 2021; 3: 1200-1202
  • 89 Lerner DK, Garvey KL, Arrighi-Allisan AE, Filimonov A, Filip P, Shah J. et al. Clinical Features of Parosmia Associated With COVID-19 Infection. The Laryngoscope 2022; 132: 633-639
  • 90 Hopkins C, Surda P, Whitehead E, Kumar BN.. Early recovery following new onset anosmia during the COVID-19 pandemic – an observational cohort study. J Otolaryngol Head Neck Surg 2020; 49: 26
  • 91 Lee Y, Min P, Lee S, Kim SW.. Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients. J Korean Med Sci 2020; 35: e174
  • 92 Boscolo-Rizzo P, Menegaldo A, Fabbris C, Spinato G, Borsetto D, Vaira LA. et al. Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19. Chem. Senses. 2021
  • 93 Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G. et al. Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. J Laryngol Otol 2020; 134: 703-709
  • 94 Lechien JR, Chiesa-Estomba CM, Beckers E, Mustin V, Ducarme M, Journe F. et al. Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients. Journal of internal medicine 2021; 290: 451-461
  • 95 Boscolo-Rizzo P, Fabbris C, Polesel J, Emanuelli E, Tirelli G, Spinato G. et al. Two-Year Prevalence and Recovery Rate of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19. JAMA Otolaryngol Head Neck Surg. 2022
  • 96 Prem B, Liu DT, Besser G, Renner B, Mueller CA.. Retronasal olfactory testing in early diagnosed and suspected COVID-19 patients: a 7-week follow-up study. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2022; 279: 257-265
  • 97 Tognetti A, Thunell E, Olsson MJ, Greilert N, Havervall S, Thålin C. et al. High prevalence of olfactory disorders 18 months after contracting COVID-19. medRxiv 2022; 269490
  • 98 Hummel T, Lotsch J.. Prognostic factors of olfactory dysfunction. Arch Otolaryngol Head Neck Surg 2010; 136: 347-351
  • 99 Liu DT, Sabha M, Damm M, Philpott C, Oleszkiewicz A, Hähner A. et al. Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training. The Laryngoscope 2021; 131: 618-623
  • 100 Brann DH, Tsukahara T, Weinreb C, Lipovsek M, van den Berge K, Gong B. et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Science Advances 2020; 6
  • 101 Najafloo R, Majidi J, Asghari A, Aleemardani M, Kamrava SK, Simorgh S. et al. Mechanism of Anosmia Caused by Symptoms of COVID-19 and Emerging Treatments. ACS Chem Neurosci 2021; 12: 3795-3805
  • 102 Zazhytska M, Kodra A, Hoagland DA, Frere J, Fullard JF, Shayya H. et al. Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. Cell 2022; 185: 1052-1064
  • 103 Melo de GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F. et al. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Science Translational Medicine 2021; 13
  • 104 Kirschenbaum D, Imbach LL, Ulrich S, Rushing EJ, Keller E, Reimann RR. et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet 2020; 396: 166
  • 105 Politi LS, Salsano E, Grimaldi M.. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia. JAMA Neurol 2020; 77: 1028-1029
  • 106 Xydakis MS, Albers MW, Holbrook EH, Lyon DM, Shih RY, Frasnelli JA. et al. Post-viral effects of COVID-19 in the olfactory system and their implications. Lancet Neurol. 2021
  • 107 Deems RO, Friedman MI, Friedman LS, Maddrey WC.. Clinical manifestations of olfactory and gustatory disorders associated with hepatic and renal disease. In: Getchell TV, Doty RL, Bartoshuk L, Snow J (eds). Smell and taste in health and disease. New York: Raven Press; 1991: 805-816
  • 108 Temmel AF, Quint C, Schickinger-Fischer B, Klimek L, Stoller E, Hummel T.. Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 2002; 128: 635-641
  • 109 Doty RL.. Clinical Disorders of Olfaction. In: Doty RL (ed). Handbook of Olfaction and Gustation. John Wiley & Sons, Inc; 2015: 375-401
  • 110 Philpott C, DeVere R.. Post-infectious and post-traumatic olfactory loss. In: Welge-Luessen A, Hummel T (eds). Management of smell and taste disorders. Stuttgart: Thieme; 2014: 91-105
  • 111 Suzuki M, Saito K, Min WP, Vladau C, Toida K, Itoh H. et al. Identification of viruses in patients with postviral olfactory dysfunction. The Laryngoscope 2007; 117: 272-7
  • 112 Jafek BW, Murrow B, Michaels R, Restrepo D, Linschoten M.. Biopsies of human olfactory epithelium. Chem. Senses 2002; 27: 623-628
  • 113 Loo AT, Youngentob SL, Kent PF, Schwob JE.. The aging olfactory epithelium: neurogenesis, response to damage, and odorant-induced activity. Int. J. Dev. Neurosci 1996; 14: 881-900
  • 114 Whitcroft KL, Cuevas M, Haehner A, Hummel T.. Patterns of olfactory impairment reflect underlying disease etiology. The Laryngoscope 2017; 127: 291-295
  • 115 Reden J, Mueller A, Mueller C, Konstantinidis I, Frasnelli J, Landis BN. et al. Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg 2006; 132: 265-269
  • 116 Hendriks A.. Olfactory dysfunction. Rhinology 1988; 26: 229-251
  • 117 Mori J, Aiba T, Sugiura M, Matsumoto K, Tomiyama K, Okuda F. et al. Clinical study of olfactory disturbance. Acta Otolaryngol Suppl (Stockh) 1998; 538: 197-201
  • 118 Duncan HJ, Seiden AM.. Long-term follow-up of olfactory loss secondary to head trauma and upper respiratory tract infection. Arch Otolaryngol Head Neck Surg 1995; 121: 1183-1187
  • 119 The Olfactory System and the Nasal Mucosa as Portals of Entry of Viruses, Drugs, and Other Exogenous Agents into the Brain. In: Handbook of Olfaction and Gustation. CRC Press; 2003:979–1020
  • 120 Youngentob SL, Schwob JE, Saha S, Manglapus G, Jubelt B.. Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM. Chemical senses 2001; 26: 953-963
  • 121 Yamagishi M, Fujiwara M, Nakamura H.. Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology 1994; 32: 113-118
  • 122 Mueller A, Rodewald A, Reden J, Gerber J, Kummer R, von Hummel T.. Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. Neuroreport 2005; 16: 475-478
  • 123 Damm M, Temmel A, Welge-Lüssen A, Eckel HE, Kreft MP, Klussmann JP. et al. Epidemiologie und Therapie von Riechstörungen in Deutschland, Österreich und der Schweiz. HNO 2004; 52: 112-120
  • 124 Rombaux P, Huart C, Levie P, Cingi C, Hummel T.. Olfaction in Chronic Rhinosinusitis. Current allergy and asthma reports 2016; 16: 41
  • 125 Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 2020; 58: 1-464
  • 126 Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M. et al. Clinical practice guideline (update): adult sinusitis. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2015; 152: S1-S39
  • 127 Stuck BA, Popert U, Beule A, Jobst D, Klimek L, LAudien M. et al. Rhinosinusitis. AWMF Leitlinien. 2017 https://www.awmf.org/leitlinien/detail/ll/017-049.html
  • 128 Lane AP, Turner J, May L, Reed R.. A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization. The Journal of neuroscience: the official journal of the Society for Neuroscience 2010; 30: 2324-2329
  • 129 Pozharskaya T, Liang J, Lane AP.. Regulation of inflammation-associated olfactory neuronal death and regeneration by the type II tumor necrosis factor receptor. International forum of allergy & rhinology 2013; 3: 740-747
  • 130 Gudziol V, Hummel T.. Effects of pentoxifylline on olfactory sensitivity: a postmarketing surveillance study. Arch Otolaryngol Head Neck Surg 2009; 135: 291-295
  • 131 Han P, Whitcroft KL, Fischer J, Gerber J, Cuevas M, Andrews P. et al. Olfactory brain gray matter volume reduction in patients with chronic rhinosinusitis. International forum of allergy & rhinology 2017; 7: 551-556
  • 132 Rombaux P, Potier H, Bertrand B, Duprez T, Hummel T.. Olfactory bulb volume in patients with sinonasal disease. Am J Rhinol 2008; 22: 598-601
  • 133 Whitcroft KL, Noltus J, Andrews P, Hummel T.. Sinonasal surgery alters brain structure and function: Neuroanatomical correlates of olfactory dysfunction. J Neurosci Res 2021; 99: 2156-2171
  • 134 Enriquez K, Lehrer E, Mullol J.. The optimal evaluation and management of patients with a gradual onset of olfactory loss. Current opinion in otolaryngology & head and neck surgery 2014; 22: 34-41
  • 135 Hernandez AK, Juratli L, Haehner A, Hsieh JW, Landis BN, Hummel T.. Assessment of olfactory fluctuations in a clinical context. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery. 2022
  • 136 Jafek BW, Moran DT, Eller PM, Rowley J.C., Jafek TB.. Steroid-dependent anosmia. Arch. Otolaryngol. Head Neck Surg.. 1987 113. 547-549
  • 137 Seiden AM.. Olfactory loss secondary to nasal and sinus pathology. In: Seiden AM (ed). Taste and smell disorders. New York: Thieme; 1997: 52-71
  • 138 Richard M, Costanzo, Laurence J, DiNardo, and Evan R.Reiter. Head Injury and Taste. In: Handbook of Olfaction and Gustation. CRC Press; 2003: 1638-1649
  • 139 Holbrook EH, Leopold DA, Schwob JE.. Abnormalities of axon growth in human olfactory mucosa. The Laryngoscope 2005; 115: 2144-2154
  • 140 Shiga H, Taki J, Okuda K, Watanabe N, Tonami H, Nakagawa H. et al. Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction. Scientific reports 2017; 7: 3581
  • 141 Lotsch J, Reither N, Bogdanov V, Hahner A, Ultsch A, Hill K. et al. A brain-lesion pattern based algorithm for the diagnosis of posttraumatic olfactory loss. Rhinology 2015; 53: 365-370
  • 142 Schofield PW, Doty RL.. The influence of head injury on olfactory and gustatory function. Handbook of clinical neurology 2019; 164: 409-429
  • 143 Costanzo RM, Zasler ND.. Epidemiology and pathophysiology of olfactory and gustatory dysfunction in head trauma, Vol 7. 1992
  • 144 Zang Y, Hähner A, Negoias S, Lakner T, Hummel T.. Apparently Minor Head Trauma Can Lead to Anosmia: A Case Report. ORL J Otorhinolaryngol Relat Spec 2021; 83: 2-6
  • 145 Christensen MD, Holbrook EH, Costanzo RM, Schwob JE.. Rhinotopy is disrupted during the re-innervation of the olfactory bulb that follows transection of the olfactory nerve. Chemical senses 2001; 26: 359-369
  • 146 Yee KK, Costanzo RM.. Changes in odor quality discrimination following recovery from olfactory nerve transection. Chemical senses 1998; 23: 513-519
  • 147 Doty RL, Yousem DM, Pham LT, Kreshak AA, Geckle R, Lee WW.. Olfactory dysfunction in patients with head trauma. Arch Neurol 1997; 54: 1131-1140
  • 148 Fan L-Y, Kuo C-L, Lirng J-F, Shu C-H.. Investigation of prognostic factors for post-traumatic olfactory dysfunction. Journal of the Chinese Medical Association: JCMA 2015; 78: 299-303
  • 149 Mueller CA, Hummel T.. Recovery of olfactory function after nine years of post-traumatic anosmia: a case report. J Med Case Rep 2009; 3: 9283
  • 150 Sumner D.. Post-traumatic anosmia. Brain 1964; 87: 107-120
  • 151 Haehner A, Hummel T, Reichmann H.. Olfactory dysfunction as a diagnostic marker for Parkinson’s disease. Expert Rev Neurother 2009; 9: 1773-1779
  • 152 Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W. et al. MDS clinical diagnostic criteria for Parkinson’s disease. Movement disorders: official journal of the Movement Disorder Society 2015; 30: 1591-1601
  • 153 Haehner A, Masala C, Walter S, Reichmann H, Hummel T.. Incidence of Parkinson’s disease in a large patient cohort with idiopathic smell and taste loss. Journal of neurology 2019; 266: 339-345
  • 154 Roos DS, Klein M, Deeg DJH, Doty RL, Berendse HW.. Prevalence of Prodromal Symptoms of Parkinson’s Disease in the Late Middle-Aged Population. J Parkinsons Dis 2022; 12: 967-974
  • 155 Doty RL, Hawkes CH.. Chemosensory dysfunction in neurodegenerative diseases. Handb Clin Neurol 2019; 164: 325-360
  • 156 Conti MZ, Vicini-Chilovi B, Riva M, Zanetti M, Liberini P, Padovani A. et al. Odor identification deficit predicts clinical conversion from mild cognitive impairment to dementia due to Alzheimer’s disease. Arch. Clin. Neuropsychol. 2013; 28: 391-399
  • 157 Leon-Sarmiento FE, Leon-Ariza DS, Doty RL.. Dysfunctional chemosensation in myasthenia gravis: a systematic review. J Clin Neuromuscul Dis 2013; 15: 1-6
  • 158 Lucassen EB, Turel A, Knehans A, Huang X, Eslinger P.. Olfactory dysfunction in Multiple Sclerosis: A scoping review of the literature. Mult Scler Relat Disord 2016; 6: 1-9
  • 159 Kohler CG, Moberg PJ, Gur RE, O’Connor MJ, Sperling MR, Doty RL.. Olfactory dysfunction in schizophrenia and temporal lobe epilepsy. Neuropsychiatry Neuropsychol Behav Neurol 2001; 4: 83-88
  • 160 Negoias S, Croy I, Gerber J, Puschmann S, Petrowski K, Joraschky P. et al. Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 2010; 169: 415-421
  • 161 Moberg PJ, Kamath V, Marchetto DM, Calkins ME, Doty RL, Hahn CG. et al. Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis. Schizophr Bull 2014; 40: 50-59
  • 162 Attems J, Walker L, Jellinger KA.. Olfactory bulb involvement in neurodegenerative diseases. Acta neuropathologica 2014; 127: 459-475
  • 163 Witt M, Bormann K, Gudziol V, Pehlke K, Barth K, Minovi A. et al. Biopsies of olfactory epithelium in patients with Parkinson’s disease. Mov Disord 2009; 24: 906-914
  • 164 Doty RL.. Treatments for smell and taste disorders: A critical review. Handb Clin Neurol 2019; 164: 455-479
  • 165 Pinto JM, Wroblewski KE, Kern DW, Schumm LP, McClintock MK. , . 2014 Oct 1, et al. Olfactory dysfunction predicts 5-year mortality in older adults. PLOS ONE 2014; 9: e107541
  • 166 Schubert CR, Fischer ME, Pinto AA, Klein BEK, Klein R, Tweed TS. et al. Sensory Impairments and Risk of Mortality in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences 2017; 72: 710-715
  • 167 Liu B, Luo Z, Pinto JM, Shiroma EJ, Tranah GJ, Wirdefeldt K. et al. Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study. Annals of internal medicine. 2019
  • 168 Doty RL, Kamath V.. The influences of age on olfaction: a review. Front. Psychol. 2014; 5: 20
  • 169 Fonteyn S, Huart C, Deggouj N, Collet S, Eloy P, Rombaux P.. Non-sinonasal-related olfactory dysfunction: A cohort of 496 patients. Eur Ann Otorhinolaryngol Head Neck Dis 2014; 131: 87-91 DOI: 10.1016/j.anorl.2013.03.006.. Epub 2014 Mar 26
  • 170 Sendon A.. Olfato, psicología y psicoanálisis. Enfoque multidisciplinario. In: In G. Soler (Ed.). Olfato y Gusto; 223-230
  • 171 Han P, Musch M, Abolmaali N, Hummel T.. Improved Odor Identification Ability and Increased Regional Gray Matter Volume After Olfactory Training in Patients With Idiopathic Olfactory Loss. i-Perception 2021; 12 20416695211005811
  • 172 Doty RL. (ed). Handbook of Olfaction and Gustation. John Wiley & Sons, Inc; 2015
  • 173 Ros C, Alobid I, Centellas S, Balasch J, Mullol J, Castelo-Branco C.. Loss of smell but not taste in adult women with Turner’s syndrome and other congenital hypogonadisms. Maturitas 2012; 73: 244-250
  • 174 Iannaccone A, Mykytyn K, Persico AM, Searby CC, Baldi A, Jablonski MM. et al. Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene. Am J Med Genet A. 2005; 132A: 343-346
  • 175 Boesveldt S, Lindau ST, McClintock MK, Hummel T, Lundstrom JN, Lindstrom JN.. Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology 2011; 49: 324-330
  • 176 Ottaviano G, Cantone E, D’Errico A, Salvalaggio A, Citton V, Scarpa B. et al. Sniffin’ Sticks and olfactory system imaging in patients with Kallmann syndrome. International forum of allergy & rhinology 2015; 5: 855-861
  • 177 Yousem DM, Geckle RJ, Bilker W, McKeown DA, Doty RL.. MR evaluation of patients with congenital hyposmia or anosmia. Am J Radiol 1996; 166: 439-443
  • 178 Abolmaali ND, Hietschold V, Vogl TJ, Hüttenbrink KB, Hummel T.. MR evaluation in patients with isolated anosmia since birth or early childhood. AJNR Am J Neuroradiol 2002; 23: 157-164
  • 179 Karstensen HG, Mang Y, Fark T, Hummel T, Tommerup N.. The first mutation in CNGA2 in two brothers with anosmia. Clin Genet 2015; 88: 293-296
  • 180 Weiss T, Soroka T, Gorodisky L, Shushan S, Snitz K, Weissgross R. et al. Human Olfaction without Apparent Olfactory Bulbs. Neuron 2020; 105: 35-45
  • 181 Rombaux P, Mouraux A, Bertrand B, Duprez T, Hummel T.. Can we smell without an olfactory bulb?. American journal of rhinology 2007; 21: 548-550
  • 182 Pfaar O, Hüttenbrink KB, Hummel T.. Assessment of olfactory function after septoplasty: A longitudinal study. Rhinology 2004; 42: 195-199
  • 183 Alobid I, Enseñat J, Mariño-Sánchez F, Notaris M, de Centellas S, Mullol J. et al. Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors. Neurosurgery 2013; 72: 540-546
  • 184 Gouveri E, Katotomichelakis M, Gouveris H, Danielides V, Maltezos E, Papanas N.. Olfactory dysfunction in type 2 diabetes mellitus: an additional manifestation of microvascular disease?. Angiology 2014; 65: 869-876
  • 185 Risberg-Berlin B, Möller RY, Finizia C.. Effectiveness of olfactory rehabilitation with the nasal airflow-inducing maneuver after total laryngectomy: one-year follow-up study. Archives of otolaryngology – head & neck surgery 2007; 133: 650-654
  • 186 Atanasova B, Graux J, El Hage W, Hommet C, Camus V, Belzung C.. Olfaction: a potential cognitive marker of psychiatric disorders. Neuroscience and biobehavioral reviews 2008; 32: 1315-1325
  • 187 Kayser J, Tenke CE, Kroppmann CJ, Alschuler DM, Ben-David S, Fekri S. et al. Olfaction in the psychosis prodrome: electrophysiological and behavioral measures of odor detection. Int J Psychophysiol 2013; 90: 190-206
  • 188 Blau JN, Solomon F.. Smell and other sensory disturbances in migraine. J. Neurol 1985; 232: 275-276
  • 189 Snyder RD, Drummond PD.. Olfaction in migraine. Cephalalgia 1997; 17: 729-32
  • 190 Holscher T, Seibt A, Appold S, Dorr W, Herrmann T, Huttenbrink KB. et al. Effects of radiotherapy on olfactory function. Radiother Oncol 2005; 77: 157-163
  • 191 Maurage P, Callot C, Chang B, Philippot P, Rombaux P, de Timary P. Olfactory impairment is correlated with confabulation in alcoholism: towards a multimodal testing of orbitofrontal cortex. PLOS ONE 2011; 6: e23190
  • 192 Maurage P, Callot C, Philippot P, Rombaux P, de Timary P. Chemosensory event-related potentials in alcoholism: a specific impairment for olfactory function, Vol 88. 2011
  • 193 Venstrom D, Amoore JE.. Olfactory threshold in relation to age, sex, or smoking. J. Food Sci 1968; 33: 264-265
  • 194 Mullol J, Alobid I, Marino-Sanchez F, Quinto L, Haro J, de Bernal-Sprekelsen M. et al. Furthering the understanding of olfaction, prevalence of loss of smell and risk factors: a population-based survey (OLFACAT study). BMJ Open 2012; 2: e001256 DOI: 10.1136/bmjopen-2012-001256.. Print 2012
  • 195 Fjaeldstad AW, Ovesen T, Hummel T.. The Association Between Smoking on Olfactory Dysfunction in 3,900 Patients With Olfactory Loss. The Laryngoscope 2021; 131: E8-E13
  • 196 Frye RE, Schwartz BS, Doty RL.. Dose-related effects of cigarette smoking on olfactory function. JAMA 1990; 263: 1233-1236
  • 197 Katotomichelakis M, Balatsouras D, Tripsianis G, Davris S, Maroudias N, Danielides V. et al. The effect of smoking on the olfactory function. Rhinology 2007; 45: 273-280
  • 198 Vent J, Robinson AM, Gentry-Nielsen MJ, Conley DB, Hallworth R, Leopold DA. et al. Pathology of the olfactory epithelium: smoking and ethanol exposure. The Laryngoscope 2004; 114: 1383-1388
  • 199 Yee KK, Pribitkin EA, Cowart BJ, Vainius AA, Klock CT, Rosen D. et al. Smoking-associated squamous metaplasia in olfactory mucosa of patients with chronic rhinosinusitis. Toxicol Pathol 2009; 37: 594-598
  • 200 Halabe-Cherem J, Salado-Burbano JC, Nellen-Hummel H.. Parosmia agradable a materia fecal propia posterior a la infección por SARS-CoV-2. Gaceta medica de Mexico 2021; 157: 636-638
  • 201 Landis BN, Frasnelli J, Hummel T.. Euosmia: a rare form of parosmia. Acta Otolaryngol 2006; 126: 101-103
  • 202 Lin S-H, Chu S-T, Yuan B-C, Shu C-H.. Survey of the Frequency of Olfactory Dysfunction in Taiwan. Journal of the Chinese Medical Association 2009; 72: 68-71
  • 203 Nordin S, Brämerson A, Millqvist E, Bende M.. Prevalence of parosmia: the Skövde population-based studies. Rhinology 2007; 45: 50-53
  • 204 Nordin S, Murphy C, Davidson TM, Quinonez C, Jalowayski AA, Ellison DW.. Prevalence and assessment of qualitative olfactory dysfunction in different age groups The Laryngoscope 1996; 106: 739-744
  • 205 Reden J, Maroldt H, Fritz A, Zahnert T, Hummel T.. A study on the prognostic significance of qualitative olfactory dysfunction. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2007; 264: 139-144
  • 206 Pellegrino R, Mainland JD, Kelly CE, Parker JK, Hummel T.. Prevalence and correlates of parosmia and phantosmia among smell disorders. Chemical senses 2021; 46
  • 207 Frasnelli J, Hummel T.. Olfactory dysfunction and daily life. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2005; 262: 231-235
  • 208 Burges Watson DL, Campbell M, Hopkins C, Smith B, Kelly C, Deary V.. Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19. PLOS ONE 2021; 16: e0256998
  • 209 Deems DA, Doty RL, Settle RG, Moore-Gillon V, Shaman P, Mester AF. et al. Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch. Otorhinolaryngol. Head Neck Surg 1991; 117: 519-528
  • 210 Hofmann FB.. Über Geruchsstörungen nach Katarrhen der Nasenhöhle. (Zur Theorie des Geruchssinnes). Muench Med Wochenschr 1918; 65: 1369
  • 211 McMillan Carr V, Ring G, Youngentob SL, Schwob JE, Farbman AI.. Altered epithelial density and expansion of bulbar projections of a discrete HSP70 immunoreactive subpopulation of rat olfactory receptor neurons in reconstituting olfactory epithelium following exposure to methyl bromide. J Comp Neurol 2004; 469: 475-493
  • 212 Cheung MC, Jang W, Schwob JE, Wachowiak M.. Functional recovery of odor representations in regenerated sensory inputs to the olfactory bulb. Frontiers in neural circuits 2013; 7: 207
  • 213 Costanzo RM.. Rewiring the olfactory bulb: changes in odor maps following recovery from nerve transection. Chem Senses 2000; 25: 199-205
  • 214 Schwob JE, Youngentob SL, Ring G, Iwema CL, Mezza RC.. Reinnervation of the rat olfactory bulb after methyl bromide-induced lesion: timing and extent of reinnervation. J Comp Neurol 1999; 412: 439-457
  • 215 John JAS, Key B.. Axon mis-targeting in the olfactory bulb during regeneration of olfactory neuroepithelium. Chem Senses 2003; 28: 773-779
  • 216 Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T.. Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. The Laryngoscope 2006; 116: 436-439
  • 217 Bitter T, Siegert F, Gudziol H, Burmeister HP, Mentzel HJ, Hummel T. et al. Gray matter alterations in parosmia. Neuroscience 2011; 177: 177-182
  • 218 Iannilli E, Leopold DA, Hornung DE, Hummel T.. Advances in Understanding Parosmia: An fMRI Study. ORL J Otorhinolaryngol Relat Spec 2019; 81: 185-192
  • 219 Christopher H. Hawkes, Richard L. Doty. Non-neurodegenerative Disorders of Olfaction. In: Smell and Taste Disorders. Cambridge University Press; 2018: 182-247
  • 220 Parker JK, Kelly CE, Gane SB.. Molecular Mechanism of Parosmia. medRxiv 2021; 21251085
  • 221 Keller A, Malaspina D.. Hidden consequences of olfactory dysfunction: a patient report series. BMC Ear Nose Throat Disord 2013; 13: 8
  • 222 Parker JK, Kelly CE, Smith BC, Kirkwood AF, Hopkins C, Gane S.. Patients’ Perspectives on Qualitative Olfactory Dysfunction: Thematic Analysis of Social Media Posts. JMIR formative research 2021; 5: e29086
  • 223 Leopold D.. Distortion of olfactory perception: diagnosis and treatment. Chem. Senses 2002; 27: 611-615
  • 224 Landis BN, Frasnelli J, Croy I, Hummel T.. Evaluating the clinical usefulness of structured questions in parosmia assessment. The Laryngoscope 2010; 120: 1707-1713
  • 225 Hummel T, Hummel C, Welge-Luessen A.. Assessment of Olfaction and Gustation. In: Welge-Luessen A, Hummel T (eds). Management of Smell and Taste Disorders – A Practical Guide for Clinicians. Stuttgart: Thieme; 2013: 58-75
  • 226 Liu DT, Welge-Lüssen A, Besser G, Mueller CA, Renner B.. Assessment of odor hedonic perception: the Sniffin’ sticks parosmia test (SSParoT). Scientific reports 2020; 10: 18019
  • 227 Sekine R, Menzel S, Hähner A, Mori E, Hummel T.. Assessment of postviral qualitative olfactory dysfunction using the short SSParoT in patients with and without parosmia. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2022; 1-4
  • 228 Frasnelli J, Landis BN, Heilmann S, Hauswald B, Huttenbrink KB, Lacroix JS. et al. Clinical presentation of qualitative olfactory dysfunction. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2004; 261: 411-415
  • 229 Sjölund S, Larsson M, Olofsson JK, Seubert J, Laukka EJ.. Phantom Smells: Prevalence and Correlates in a Population-Based Sample of Older Adults. Chemical senses 2017; 42: 309-318
  • 230 Bainbridge KE, Byrd-Clark D, Leopold D.. Factors Associated With Phantom Odor Perception Among US Adults: Findings From the National Health and Nutrition Examination Survey. JAMA otolaryngology – head & neck surgery 2018; 144: 807-814
  • 231 Croy I, Nordin S, Hummel T.. Olfactory disorders and quality of life –an updated review. Chemical senses 2014; 39: 185-194
  • 232 Ohayon MM.. Prevalence of hallucinations and their pathological associations in the general population. Psychiatry Res 2000; 97: 153-164
  • 233 Holbrook EH, Puram SV, See RB, Tripp AG, Nair DG.. Induction of smell through transethmoid electrical stimulation of the olfactory bulb. International forum of allergy & rhinology 2019; 9: 158-164
  • 234 Kumar G, Juhász C, Sood S, Asano E.. Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: effects of direct stimulation of olfactory bulb and tract. Epilepsy & behavior: E&B 2012; 24: 264-268
  • 235 Bérard N, Landis BN, Legrand L, Tyrand R, Grouiller F, Vulliémoz S. et al. Electrical stimulation of the medial orbitofrontal cortex in humans elicits pleasant olfactory perceptions. Epilepsy & behavior: E&B 2021; 114: 107559
  • 236 Kaufman MD, Lassiter KR, Shenoy BV.. Paroxysmal unilateral dysosmia: a cured patient. Annals of neurology 1988; 24: 450-451
  • 237 Markert JM, Hartshorn DO, Farhat SM.. Paroxysmal bilateral dysosmia treated by resection of the olfactory bulbs. Surg Neurol 1993; 40: 160-163
  • 238 Leopold DA, Loehrl TA, Schwob JE.. Long-term follow-up of surgically treated phantosmia. Arch Otolaryngol Head Neck Surg 2002; 128: 642-7
  • 239 Morrissey DK, Pratap U, Brown C, Wormald P-J.. The role of surgery in the management of phantosmia. The Laryngoscope 2016; 126: 575-578
  • 240 Fikentscher R, Gudziol H, Roseburg B.. Einteilung und Begriffsbestimmung der Riech- und Schmeckstörungen. Laryngo-Rhino-Otol 1987; 66: 355-357
  • 241 Landis BN, Reden J, Haehner A.. Idiopathic phantosmia: outcome and clinical significance. ORL J Otorhinolaryngol Relat Spec 2010; 72: 252-255
  • 242 Whitcroft KL, Hummel T.. Olfactory Dysfunction in COVID-19: Diagnosis and Management. JAMA 2020; 323: 2512-2514
  • 243 Damm M, Hüttenbrink KB, Hummel T, Landis B, Göktas Ö, Muttray A, Blankenburg M, Höglinger G, Schmitl L.. AWMF Leitlinien “Riech- und Schmeckstörungen”. 2017 https://www.awmf.org/uploads/tx_szleitlinien/017-050l_S2k_Riech-und-Schmeckst%C3%B6rungen_2017-03.pdf
  • 244 Soler ZM, Hyer JM, Karnezis TT, Schlosser RJ.. The Olfactory Cleft Endoscopy Scale correlates with olfactory metrics in patients with chronic rhinosinusitis. International forum of allergy & rhinology 2016; 6: 293-298
  • 245 Lund VJ, Kennedy DW.. Quantification for staging sinusitis. The Staging and Therapy Group. The Annals of otology, rhinology & laryngology. Supplement 1995; 167: 17-21
  • 246 Hummel T, Landis BN, Huttenbrink KB.. Smell and taste disorders. GMS Curr Top Otorhinolaryngol Head Neck Surg 2011; 10:: Doc04
  • 247 Hopkins C, Gillett S, Slack R, Lund VJ, Browne JP.. Psychometric validity of the 22-item Sinonasal Outcome Test. Clin Otolaryngol 2009; 34: 447-454
  • 248 Soler ZM, Smith TL, Alt JA, Ramakrishnan VR, Mace JC, Schlosser RJ.. Olfactory-specific quality of life outcomes after endoscopic sinus surgery. International forum of allergy & rhinology 2016; 6: 407-413
  • 249 Zou L-Q, Linden L, Cuevas M, Metasch M-L, Welge-Lüssen A, Hähner A. et al. Self-reported mini olfactory questionnaire (Self-MOQ): A simple and useful measurement for the screening of olfactory dysfunction. The Laryngoscope 2020; 130: E786-E790
  • 250 Landis BN, Hummel T, Hugentobler M, Giger R, Lacroix JS.. Ratings of overall olfactory function. Chemical senses 2003; 28: 691-694
  • 251 Philpott CM, Wolstenholme CR, Goodenough PC, Clark A, Murty GE.. Comparison of subjective perception with objective measurement of olfaction. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2006; 134: 488-490
  • 252 Philpott CM, Rimal D, Tassone P, Prinsley PR, Premachandra DJ.. A study of olfactory testing in patients with rhinological pathology in the ENT clinic. Rhinology 2008; 46: 34-39
  • 253 Wehling E, Lundervold AJ, Espeset T, Reinvang I, Bramerson A, Nordin S.. Even cognitively well-functioning adults are unaware of their olfactory dysfunction: Implications for ENT clinicians and researchers. Rhinology 2015; 53: 89-94
  • 254 Hedner M, Larsson M, Arnold N, Zucco GM, Hummel T.. Cognitive factors in odor detection, odor discrimination, and odor identification tasks. J Clin Exp Neuropsychol 2010; 32: 1062-1067
  • 255 Sorokowska A, Albrecht E, Hummel T.. Reading first or smelling first? Effects of presentation order on odor identification. Atten Percept Psychophys 2015; 77: 731-736
  • 256 Doty RL, McKeown DA, Lee WW, Shaman P.. A study of the test-retest reliability of ten olfactory tests. Chem Senses 1995; 20: 645-656
  • 257 Doty RL, Smith R, McKeown DA, Raj J.. Tests of human olfactory function: principle component analysis suggests that most measure a common source of variance. Percept Psychophys 1994; 56: 701-707
  • 258 Jones-Gotman M, Zatorre RJ.. Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 1988; 26: 387-400
  • 259 Hornung DE, Kurtz DB, Bradshaw CB, Seipel DM, Kent PF, Blair DC. et al. The olfactory loss that accompanies an HIV infection. Physiol Behav 1998; 15: 549-556
  • 260 Lotsch J, Reichmann H, Hummel T.. Different odor tests contribute differently to the evaluation of olfactory loss. Chemical senses 2008; 33: 17-21
  • 261 Cain WS, Gent JF, Goodspeed RB, Leonard G.. Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center (CCCRC). The Laryngoscope 1988; 98: 83-88
  • 262 Doty RL, Shaman P, Dann M.. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiology & behavior 1984; 32: 489-502
  • 263 Picillo M, Iavarone A, Pellecchia MT, Amboni M, Erro R, Moccia M. et al. Validation of an Italian version of the 40-item University of Pennsylvania Smell Identification Test that is physician administered: our experience on one hundred and thirty-eight healthy subjects. Clinical otolaryngology: official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial. Surgery 2014; 39: 53-57
  • 264 Taherkhani S, Moztarzadeh F, Mehdizadeh Seraj J, Hashemi Nazari SS, Taherkhani F, Gharehdaghi J. et al. Iran Smell Identification Test (Iran-SIT): a Modified Version of the University of Pennsylvania Smell Identification Test (UPSIT) for Iranian Population. Chem. Percept 2015; 8: 183-191
  • 265 Thamboo A, Santos RCD, Naidoo L, Rahmanian R, Chilvers MA, Chadha NK.. Use of the SNOT-22 and UPSIT to appropriately select pediatric patients with cystic fibrosis who should be referred to an otolaryngologist: cross-sectional study. JAMA otolaryngology – head & neck surgery 2014; 140: 934-939
  • 266 Razmpa E, Saedi B, Safavi A, Mohammadi S.. Olfactory function after nasal plastic surgery. B-ENT 2013; 9: 269-275
  • 267 Saedi B, Sadeghi M, Yazdani N, Afshari A.. Effectiveness of FESS in Smell Improvement of Sinusitis Patients. Indian J Otolaryngol Head Neck Surg 2013; 65: 283-287
  • 268 Shemshadi H, Azimian M, Onsori MA, AzizAbadi Farahani M.. Olfactory function following open rhinoplasty: A 6-month follow-up study. BMC Ear Nose Throat Disord 2008; 8: 6
  • 269 Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G.. ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chemical senses 1997; 22: 39-52
  • 270 Gudziol V, Lötsch J, Hähner A, Zahnert T, Hummel T.. Clinical significance of results from olfactory testing. The Laryngoscope 2006; 116: 1858-1863
  • 271 Gudziol H, Wächter R.. Gibt es olfaktorisch evozierte Atemänderungen?. Laryngo-Rhino-Otol 2004; 83: 367-373
  • 272 Gudziol H, Stark D, Lehnich H, Bitter T, Guntinas-Lichius O.. Hyposmiker haben weniger evozierte respiratorische Orientierungsreaktionen als Normosmiker. Laryngo-Rhino-Otol 2010; 89: 477-482
  • 273 Schriever VA, Agosin E, Altundag A, Avni H, Cao Van H, Cornejo C. et al. Development of an International Odor Identification Test for Children: The Universal Sniff Test. J Pediatr 2018; 198: 265-272
  • 274 Cameron EL, Doty RL.. Odor identification testing in children and young adults using the smell wheel. Int J Pediatr Otorhinolaryngol 2013; 77: 346-350
  • 275 Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM. et al. Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2000; 257: 205-211
  • 276 Klimek L, Hummel T, Moll B, Kobal G, Mann WJ.. Lateralized and bilateral olfactory function in patients with chronic sinusitis compared with healthy control subjects. The Laryngoscope 1998; 108: 111-114
  • 277 Welge-Lüssen A, Gudziol V, Wolfensberger M, Hummel T.. Olfactory testing in clinical settings – is there additional benefit from unilateral testing?. Rhinology 2010; 48: 156-159
  • 278 Gudziol V, Hummel C, Negoias S, Ishimaru T, Hummel T.. Lateralized differences in olfactory function. The Laryngoscope 2007; 117: 808-811
  • 279 Huart C, Rombaux P, Gérard T, Hanseeuw B, Lhommel R, Quenon L. et al. Unirhinal Olfactory Testing for the Diagnostic Workup of Mild Cognitive Impairment. Journal of Alzheimer’s Disease 2015; 47: 253
  • 280 Doty R, Marcus A, Lee WW.. Development of the 12-item cross-cultural smell identification test (CC-SIT). The Laryngoscope 1996; 106: 353-356
  • 281 Hummel T, Konnerth CG, Rosenheim K, Kobal G.. Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. The Annals of otology, rhinology, and laryngology 2001; 110: 976-981
  • 282 Jackman AH, Doty RL.. Utility of a three-item smell identification test in detecting olfactory dysfunction. The Laryngoscope 2005; 115: 2209-2212
  • 283 Mueller C, Renner B.. A new procedure for the short screening of olfactory function using five items from the “Sniffin’ Sticks” identification test kit. Am J Rhinol 2006; 20: 113-116
  • 284 Gupta S, Kallogjeri D, Farrell NF, Lee JJ, Smith HJ, Khan AM. et al. Development and Validation of a Novel At-home Smell Assessment. JAMA otolaryngology – head & neck surgery 2022; 148: 252-258
  • 285 Parma V, Hannum ME, O’Leary M, Pellegrino R, Rawson NE, Reed DR. et al. SCENTinel 1.0: Development of a Rapid Test to Screen for Smell Loss. Chemical senses 2021; 46
  • 286 Sheen F, Tan V, Lim AJ, Haldar S, Sengupta S, Allen D. et al. The COVOSMIA-19 trial: Preliminary application of the Singapore smell and taste test to objectively measure smell and taste function with COVID-19. Food Qual Pref 2022; 97: 104482
  • 287 Li Z, Stolper S, Draf J, Haehner A, Hummel T.. Smell, taste and trigeminal function: similarities and differences between results from home tests and examinations in the clinic. Rhinology 2022; DOI: 10.4193/Rhin21.430.
  • 288 Negoias S, Meves B, Zang Y, Haehner A, Hummel T.. Characteristics of Olfactory Disorder With and Without Reported Flavor Loss. The Laryngoscope 2020; 130: 2869-2873
  • 289 Heilmann S, Strehle G, Rosenheim K, Damm M, Hummel T.. Clinical assessment of retronasal olfactory function. Arch Otolaryngol Head Neck Surg 2002; 128: 414-418
  • 290 Renner B, Mueller CA, Dreier J, Faulhaber S, Rascher W, Kobal G.. The candy smell test: a new test for retronasal olfactory performance. Laryngoscope 2009; 119: 487-495
  • 291 Yoshino A, Goektas G, Mahmut MK, Zhu Y, Goektas O, Komachi T. et al. A New Method for Assessment of Retronasal Olfactory Function. The Laryngoscope 2021; 131: E324-e330
  • 292 Rombaux P, Huart C, Deggouj N, Duprez T, Hummel T.. Prognostic value of olfactory bulb volume measurement for recovery in postinfectious and posttraumatic olfactory loss. Otolaryngology—head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2012; 147: 1136-1141
  • 293 Huart C, Rombaux P, Hummel T, Mouraux A.. Clinical usefulness and feasibility of time-frequency analysis of chemosensory event-related potentials. Rhinology 2013; 51: 210-221
  • 294 Lundström JN, Gordon AR, Alden EC, Boesveldt S, Albrecht J.. Methods for building an inexpensive computer-controlled olfactometer for temporally-precise experiments. Int J Psychophysiol 2010; 78: 179-189
  • 295 Lundström JN, Boesveldt S, Albrecht J.. Central Processing of the Chemical Senses: an Overview. ACS Chem Neurosci 2011; 2: 5-16
  • 296 Zang Y, Han P, Joshi A, Hummel T.. Individual variability of olfactory fMRI in normosmia and olfactory dysfunction. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2021; 278: 379-387
  • 297 Alobid I, Benítez P, Cardelús S, Borja Callejas de F, Lehrer-Coriat E, Pujols L. et al. Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis. The Laryngoscope 2014; 124: 50-56
  • 298 Banglawala SM, Oyer SL, Lohia S, Psaltis AJ, Soler ZM, Schlosser RJ.. Olfactory outcomes in chronic rhinosinusitis with nasal polyposis after medical treatments: a systematic review and meta-analysis. International forum of allergy & rhinology 2014; 4: 986-994
  • 299 Golding-Wood DG, Holmstrom M, Darby Y, Scadding GK, Lund VJ.. The treatment of hyposmia with intranasal steroids. J. Laryngol. Otol 1996; 110: 132-135
  • 300 Chong LY, Head K, Hopkins C, Philpott C, Burton MJ, Schilder AGM.. Different types of intranasal steroids for chronic rhinosinusitis. The Cochrane database of systematic reviews 2016; 4: CD011993
  • 301 Chong LY, Head K, Hopkins C, Philpott C, Schilder AGM, Burton MJ.. Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis. The Cochrane database of systematic reviews 2016; 4: CD011996
  • 302 Head K, Chong LY, Hopkins C, Philpott C, Schilder AGM, Burton MJ.. Short-course oral steroids as an adjunct therapy for chronic rhinosinusitis. The Cochrane database of systematic reviews 2016; 4: CD011992
  • 303 Head K, Chong LY, Hopkins C, Philpott C, Burton MJ, Schilder AGM.. Short-course oral steroids alone for chronic rhinosinusitis. The Cochrane database of systematic reviews 2016; 4: CD011991
  • 304 Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM. et al. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. International forum of allergy & rhinology 2016; 6 (Suppl. 01) S22-209
  • 305 Hopkins C, Philpott C, Crowe S, Regan S, Degun A, Papachristou I. et al. Identifying the most important outcomes for systematic reviews of interventions for rhinosinusitis in adults: working with Patients, Public and Practitioners. Rhinology 2016; 54: 20-26
  • 306 Rimmer J, Fokkens W, Chong LY, Hopkins C.. Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps. The Cochrane database of systematic reviews 2014; CD006991
  • 307 Mainland JD, Barlow LA, Munger SD, Millar SE, Vergara MN, Jiang P. et al. Identifying treatments for taste and smell disorders: gaps and opportunities. Chemical senses 2020; 45: 493-502
  • 308 Patel ZM, Holbrook EH, Turner JH, Adappa ND, Albers MW, Altundag A. et al. International consensus statement on allergy and rhinology: Olfaction. International forum of allergy & rhinology 2022; 12: 327-680
  • 309 Ikeda K, Sakurada T, Suzaki Y, Takasaka T.. Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease. Rhinology 1995; 33: 162-165
  • 310 Genetzaki S, Tsakiropoulou E, Nikolaidis V, Markou K, Konstantinidis I.. Postinfectious Olfactory Dysfunction: Oral Steroids and Olfactory Training versus Olfactory Training Alone: Is There any Benefit from Steroids?. ORL 2021; 83: 387-394
  • 311 Heilmann S, Just T, Goktas O, Hauswald B, Huttenbrink KB, Hummel T.. [Effects of systemic or topical administration of corticosteroids and vitamin B in patients with olfactory loss]. Laryngorhinootologie 2004; 83: 729-734
  • 312 Stenner M, Vent J, Huttenbrink KB, Hummel T, Damm M.. Topical therapy in anosmia: relevance of steroid-responsiveness. The Laryngoscope 2008; 118: 1681-1686
  • 313 Fukazawa K.. A local steroid injection method for olfactory loss due to upper respiratory infection. Chemical senses 2005; 30 Suppl 1 i212-3
  • 314 Le Bon SD, Pisarski N, Verbeke J, Prunier L, Cavelier G, Thill MP. et al. Psychophysical evaluation of chemosensory functions 5 weeks after olfactory loss due to COVID-19: a prospective cohort study on 72 patients. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2021; 278: 101-108
  • 315 Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Cutrupi S, Salzano G. et al. Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients. Rhinology 2021; 59: 21-25
  • 316 Fujii M, Fukazawa K, Hatta C, Yasuno H, Sakagami M.. Olfactory acuity after total laryngectomy. Chemical senses 2002; 27: 117-21
  • 317 Jiang R-S, Wu S-H, Liang K-L, Shiao J-Y, Hsin C-H, Su M-C.. Steroid treatment of posttraumatic anosmia. Eur Arch Otorhinolaryngol 2010; 267: 1563-1567
  • 318 Bratt M, Moen KG, Nordgård S, Helvik A-S, Skandsen T.. Treatment of posttraumatic olfactory dysfunction with corticosteroids and olfactory training. Acta oto-laryngologica 2020; 140: 761-767
  • 319 Jiang RS, Twu CW, Liang KL.. Medical treatment of traumatic anosmia. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2015; 152: 954-958
  • 320 Scheibe M, Bethge C, Witt M, Hummel T.. Intranasal administration of drugs. Archives of otolaryngology – head & neck surgery 2008; 134: 643-646
  • 321 Shu CH, Lee PL, Shiao AS, Chen KT, Lan MY.. Topical corticosteroid applied with a squirt system being more effective than with nasal spray for steroid-dependent olfactory impairment. The Laryngoscope 2012; 122: 747-750
  • 322 Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ. et al. Techniques of intranasal steroid use. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2004; 130: 5-24
  • 323 Blomqvist EH, Lundblad L, Bergstedt H, Stjarne P.. Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia. Acta Otolaryngol 2003; 123: 862-868
  • 324 Heilmann S, Huettenbrink KB, Hummel T.. Local and systemic administration of corticosteroids in the treatment of olfactory loss. Am J Rhinol 2004; 18: 29-33
  • 325 Fleiner F, Lau L, Goktas O.. Active olfactory training for the treatment of smelling disorders. Ear Nose Throat J 2012; 91: 198-203 215
  • 326 Kim DH, Kim SW, Hwang SH, Kim BG, Kang JM, Cho JH. et al. Prognosis of Olfactory Dysfunction according to Etiology and Timing of Treatment. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2017; 156: 371-377
  • 327 Hintschich CA, Dietz M, Haehner A, Hummel T.. Topical Administration of Mometasone Is Not Helpful in Post-COVID-19 Olfactory Dysfunction. Life 2022; 12: 1483
  • 328 Kasiri H, Rouhani N, Salehifar E, Ghazaeian M, Fallah S.. Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial. Int Immunopharmacol 2021; 98: 107871
  • 329 Abdelalim AA, Mohamady AA, Elsayed RA, Elawady MA, Ghallab AF.. Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial. Am J Otolaryngol 2021; 42: 102884
  • 330 Nguyen TP, Patel ZM.. Budesonide irrigation with olfactory training improves outcomes compared with olfactory training alone in patients with olfactory loss. International forum of allergy & rhinology 2018; 8: 977-981
  • 331 Asvapoositkul V, Samuthpongtorn J, Aeumjaturapat S, Snidvongs K, Chusakul S, Seresirikachorn K. et al. Therapeutic options of post-COVID-19 related olfactory dysfunction: a systematic review and meta-analysis. Rhinology. 2022
  • 332 Addison AB, Wong B, Ahmed T, Macchi A, Konstantinidis I, Huart C. et al. Clinical Olfactory Working Group Consensus Statement on the Treatment of Post Infectious Olfactory Dysfunction. The Journal of allergy and clinical immunology. 2021
  • 333 Henkin RI, Hosein S, Stateman WA, Knoppel AB, Abdelmeguid M.. Improved smell function with increased nasal mucus sonic hedgehog in hyposmic patients after treatment with oral theophylline. Am J Otolaryngol 2017; 38: 143-147
  • 334 Hosein W, Henkin RI.. Therapeutic diminution of Interleukin-10 with intranasal theophylline administration in hyposmic patients. American journal of otolaryngology 2022; 43: 103375
  • 335 Henkin RI, Velicu I, Schmidt L.. An open-label controlled trial of theophylline for treatment of patients with hyposmia. Am J Med Sci 2009; 337: 396-406
  • 336 Henkin RI, Schultz M, Minnick-Poppe L.. Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Arch Otolaryngol Head Neck Surg 2012; 138: 1064-1070
  • 337 Lee JJ, Peterson AM, Kallogjeri D, Jiramongkolchai P, Kukuljan S, Schneider JS. et al. Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction. American journal of otolaryngology 2022; 43: 103299
  • 338 Meusel T, Albinus J, Welge-Luessen A, Hahner A, Hummel T.. Short-term effect of caffeine on olfactory function in hyposmic patients. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2016; 273: 2091-2095
  • 339 Gudziol V, Pietsch J, Witt M, Hummel T.. Theophylline induces changes in the electro-olfactogram of the mouse. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2010; 267: 239-243
  • 340 Gudziol V, Mück-Weymann M, Seizinger O, Rauh R, Siffert W, Hummel T.. Sildenafil affects olfactory function. J Urol 2007; 177: 258-61 discussion 261
  • 341 Zufall F, Shepherd GM, Firestein S.. Inhibition of the olfactory cyclic nucleotide gated ion channel by intracellular calcium. Proceedings. Biological sciences 1991; 246: 225-230
  • 342 Panagiotopoulos G, Naxakis S, Papavasiliou A, Filipakis K, Papatheodorou G, Goumas P.. Decreasing nasal mucus Ca++ improves hyposmia. Rhinology 2005; 43: 130-134
  • 343 Whitcroft KL, Merkonidis C, Cuevas M, Haehner A, Philpott C, Hummel T.. Intranasal sodium citrate solution improves olfaction in post-viral hyposmia. Rhinology 2016; 54: 368-374
  • 344 Philpott CM, Erskine SE, Clark A, Leeper A, Salam M, Sharma R. et al. A randomised controlled trial of sodium citrate spray for non-conductive olfactory disorders. Clin Otolaryngol 2017; 42: 1295-1302
  • 345 Whitcroft KL, Gunder N, Cuevas M, Andrews P, Menzel S, Haehner A. et al. Intranasal sodium citrate in quantitative and qualitative olfactory dysfunction: results from a prospective, controlled trial of prolonged use in 60 patients. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery. 2021
  • 346 Abdelazim MH, Abdelazim AH.. Effect of Sodium Gluconate on Decreasing Elevated Nasal Calcium and Improving Olfactory Function Post COVID-19 Infection. American journal of rhinology & allergy. 2022 19458924221120116
  • 347 Abdelazim MH, Abdelazim AH, Ismaiel WF, Alsobky ME, Younes A, Hadeya AM. et al. Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patients. Eur Arch Otorhinolaryngol 2022; 4623-4628
  • 348 Abdelazim MH, Abdelazim AH, Moneir W.. The effect of intra-nasal tetra sodium pyrophosphate on decreasing elevated nasal calcium and improving olfactory function post COVID-19: a randomized controlled trial. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology 2022; 18: 67
  • 349 Rawson NE, LaMantia A-S.. A speculative essay on retinoic acid regulation of neural stem cells in the developing and aging olfactory system. Experimental Gerontology 2007; 42: 46-53
  • 350 Rawson NE.. Olfactory loss in aging. Sci Aging Knowledge Environ 2006; 2006: pe6
  • 351 Anchan RM, Drake DP, Haines CF, Gerwe EA, LaMantia AS.. Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway. J Comp Neurol 1997; 379: 171-184
  • 352 Zhang QY.. Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice. Biochemical and biophysical research communications 1999; 256: 346-351
  • 353 Paschaki M, Cammas L, Muta Y, Matsuoka Y, Mak S-S, Rataj-Baniowska M. et al. Retinoic acid regulates olfactory progenitor cell fate and differentiation. Neural development 2013; 8: 13
  • 354 Whitesides J, Hall M, Anchan R, LaMantia AS.. Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse. J Comp Neurol 1998; 394: 445-461
  • 355 Etchamendy N, Enderlin V, Marighetto A, Vouimba R-M, Pallet V, Jaffard R. et al. Alleviation of a Selective Age-Related Relational Memory Deficit in Mice by Pharmacologically Induced Normalization of Brain Retinoid Signaling. J Neurosci 2001; 21: 6423-6429
  • 356 Duncan RB, Briggs M.. Treatment of uncomplicated anosmia by vitamin A. Arch.Otolaryng.(Chic.) 1962; 75: 116
  • 357 Kartal D, Yaşar M, Kartal L, Özcan I, Borlu M.. Effects of isotretinoin on the olfactory function in patients with acne. Anais Brasileiros de Dermatologia 2017; 92: 191-195
  • 358 Reden J, Lill K, Zahnert T, Haehner A, Hummel T.. Olfactory function in patients with postinfectious and posttraumatic smell disorders before and after treatment with vitamin A: a double-blind, placebo-controlled, randomized clinical trial. The Laryngoscope 2012; 122: 1906-1909
  • 359 Hummel T, Whitcroft KL, Rueter G, Haehner A.. Intranasal vitamin A is beneficial in post-infectious olfactory loss. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2017; 274: 2819-2825
  • 360 Health Research Authority. Vitamin A Proof of Concept Study Post-Viral Olfactory Loss; 2022. https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/vitamin-a-proof-of-concept-study-post-viral-olfactory-loss/ (accessed 02. Oktober 2022)
  • 361 Wang L, Chen L, Jacob T.. Evidence for peripheral plasticity in human odour response. J. Physiol 2004; 554: 236-244
  • 362 Riechtraining. https://www.uniklinikum-dresden.de/de/das-klinikum/kliniken-polikliniken-institute/hno/forschung/interdisziplinaeres-zentrum-fuer-riechen-und-schmecken/downloads/videos/riechtraining/riechtraining-deutsch/@@view/++widget++form.widgets.IVideo.video_file/@@stream (accessed 03. Oktober 2022)
  • 363 Youngentob SL, Kent PF.. Enhancement of odorant-induced mucosal activity patterns in rats trained on an odorant. Brain Res 1995; 670: 82-88
  • 364 Hummel T, Stupka G, Haehner A, Poletti SC.. Olfactory training changes electrophysiological responses at the level of the olfactory epithelium. Rhinology 2018; 56: 330-335
  • 365 Kim BY, Park JY, Kim EJ, Kim BG.. Olfactory Ensheathing Cells Mediate Neuroplastic Mechanisms After Olfactory Training in Mouse Model. Am J Rhinol Allerg 2020; 34: 217-229
  • 366 Watt WC, Sakano H, Lee Z-Y, Reusch JE, Trinh K, Storm DR.. Odorant Stimulation Enhances Survival of Olfactory Sensory Neurons via MAPK and CREB. Neuron 2004; 41: 955-967
  • 367 Negoias S, Hummel T, Symmank A, Schellong J, Joraschky P, Croy I.. Olfactory bulb volume predicts therapeutic outcome in major depression disorder. Brain Imaging Behav 2016; 10: 367-372
  • 368 Al Aïn S, Poupon D, Hétu S, Mercier N, Steffener J, Frasnelli J.. Smell training improves olfactory function and alters brain structure. NeuroImage 2019; 189: 45-54
  • 369 Kollndorfer K, Fischmeister FPS, Kowalczyk K, Hoche E, Mueller CA, Trattnig S. et al. Olfactory training induces changes in regional functional connectivity in patients with long-term smell loss. Neuroimage Clin 2015; 9: 401-410
  • 370 Hummel T, Rissom K, Reden J, Hahner A, Weidenbecher M, Huttenbrink KB.. Effects of olfactory training in patients with olfactory loss. The Laryngoscope 2009; 119: 496-499
  • 371 Geissler K, Reimann H, Gudziol H, Bitter T, Guntinas-Lichius O.. Olfactory training for patients with olfactory loss after upper respiratory tract infections. Eur Arch Otorhinolaryngol 2014; 271: 1557-62 DOI: 10.1007/s00405-013-2747-y.. Epub 2013 Oct 6
  • 372 Pieniak M, Oleszkiewicz A, Avaro V, Calegari F, Hummel T.. Olfactory training – Thirteen years of research reviewed. Neurosci Biobehav Rev 2022; 141: 104853
  • 373 Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B. et al. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. The Laryngoscope 2014; 124: 826-831
  • 374 Altundag A, Cayonu M, Kayabasoglu G, Salihoglu M, Tekeli H, Saglam O. et al. Modified olfactory training in patients with postinfectious olfactory loss. The Laryngoscope 2015; 125: 1763-1766
  • 375 Altundag A, Yilmaz E, Kesimli MC.. Modified Olfactory Training Is an Effective Treatment Method for COVID-19 Induced Parosmia. The Laryngoscope 2022; 132: 1433-1438
  • 376 Kattar N, Do TM, Unis GD, Migneron MR, Thomas AJ, McCoul ED.. Olfactory Training for Postviral Olfactory Dysfunction: Systematic Review and Meta-analysis. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2021 194599820943550
  • 377 Konstantinidis I, Tsakiropoulou E, Bekiaridou P, Kazantzidou C, Constantinidis J.. Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction. Laryngoscope. 2013; 123: 85-90
  • 378 Langdon C, Lehrer E, Berenguer J, Laxe S, Alobid I, Quintó L. et al. Olfactory Training in Post-Traumatic Smell Impairment: Mild Improvement in Threshold Performances: Results from a Randomized Controlled Trial. Journal of neurotrauma 2018; 35: 2641-2652
  • 379 Jiang R-S, Twu C-W, Liang K-L.. The effect of olfactory training on the odor threshold in patients with traumatic anosmia. American journal of rhinology & allergy 2017; 31: 317-322
  • 380 Jiang R-S, Twu C-W, Liang K-L.. The effect of olfactory training on odor identification in patients with traumatic anosmia. International forum of allergy & rhinology 2019; 9: 1244-1251
  • 381 Haehner A, Tosch C, Wolz M, Klingelhoefer L, Fauser M, Storch A. et al. Olfactory training in patients with Parkinson’s disease. PLOS ONE 2013; 8: e61680
  • 382 Pekala K, Chandra RK, Turner JH.. Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. International forum of allergy & rhinology 2016; 6: 299-307
  • 383 Sorokowska A, Drechsler E, Karwowski M, Hummel T.. Effects of olfactory training: a meta-analysis. Rhinology 2017; 55: 17-26
  • 384 Sharma R, Lakhani R, Rimmer J, Hopkins C.. Surgical interventions for chronic rhinosinusitis with nasal polyps. The Cochrane database of systematic reviews 2014; 11: CD006990
  • 385 Kohli P, Naik AN, Farhood Z, Ong AA, Nguyen SA, Soler ZM. et al. Olfactory Outcomes after Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Meta-analysis. Otolaryngology – head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2016; 155: 936-948
  • 386 Pade J, Hummel T.. Olfactory function following nasal surgery. The Laryngoscope 2008; 118: 1260-1264
  • 387 Whitcroft KL, Fischer J, Han P, Raue C, Bensafi M, Gudziol V. et al. Structural Plasticity of the Primary and Secondary Olfactory cortices: Increased Gray Matter Volume Following Surgical Treatment for Chronic Rhinosinusitis. Neuroscience 2018; 395: 22-34
  • 388 Schriever VA, Gupta N, Pade J, Szewczynska M, Hummel T.. Olfactory function following nasal surgery: a 1-year follow-up. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2013; 270: 107-111
  • 389 Pfaff MJ, Bertrand AA, Lipman KJ, Shah A, Nolan I, Krishna V. et al. The Effect of Functional Nasal Surgery on Olfactory Function. Plastic and reconstructive surgery 2021; 147: 707-718
  • 390 Damm M, Eckel HE, Jungehulsing M, Hummel T.. Olfactory changes at threshold and suprathreshold levels following septoplasty with partial inferior turbinectomy. The Annals of otology, rhinology, and laryngology 2003; 112: 91-97
  • 391 Besser G, Liu DT, Sharma G, Bartosik TJ, Kaphle S, Enßlin M. et al. Ortho- and retronasal olfactory performance in rhinosurgical procedures: a longitudinal comparative study. Eur Arch Otorhinolaryngol 2021; 278: 397-403
  • 392 Elbistanli MS, Koçak HE, Çelik M, Acipayam H, Alakhras WME, Koç AK. et al. Significance of Medial Osteotomy on the Olfactory Function in Patients Who Underwent Septorhinoplasty. The. Journal of craniofacial surgery 2019; 30: e106-e109
  • 393 Poirrier A-L, Ahluwalia S, Goodson A, Ellis M, Bentley M, Andrews P.. Is the Sino-Nasal Outcome Test-22 a suitable evaluation for septorhinoplasty?. The Laryngoscope 2013; 123: 76-81
  • 394 Randhawa PS, Watson N, Lechner M, Ritchie L, Choudhury N, Andrews PJ.. The outcome of septorhinoplasty surgery on olfactory function. Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2016; 41: 15-20
  • 395 Ulusoy S, Dinç ME, Dalğıç A, Dizdar D, Avınçsal MÖ, Külekçi M.. Effects of Spreader Grafts on Olfactory Function in Septorhinoplasty. Aesthetic plastic surgery 2016; 40: 106-113
  • 396 Jankowski R, Bodino C.. Olfaction in patients with nasal polyposis: effects of systemic steroids and radical ethmoidectomy with middle turbinate resection (nasalization). Rhinology 2003; 41: 220-230
  • 397 Kuffler DP.. Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction. Molecular neurobiology 2015; 52: 990-1014
  • 398 Anitua E, Pascual C, Pérez-Gonzalez R, Antequera D, Padilla S, Orive G. et al. Intranasal delivery of plasma and platelet growth factors using PRGF-Endoret system enhances neurogenesis in a mouse model of Alzheimer’s disease. PLOS ONE 2013; 8: e73118
  • 399 Yasak AG, Yigit O, Araz Server E, Durna Dastan S, Gul M.. The effectiveness of platelet-rich plasma in an anosmia-induced mice model. The Laryngoscope 2018; 128: E157-E162
  • 400 Mavrogeni P, Kanakopoulos A, Maihoub S, Krasznai M, Szirmai A.. Anosmia treatment by platelet rich plasma injection. The international tinnitus journal 2017; 20: 102-105
  • 401 Yan CH, Mundy DC, Patel ZM.. The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study. Laryngoscope investigative otolaryngology 2020; 5: 187-193
  • 402 Klug T, Rosen D, Chaskes M, Souza GD, Pribitkin E.. Treatment of refractory anosmia with topical platelet rich plasma. Otolaryngology – Head and Neck Surgery 2021; P344-P345
  • 403 Greiner RS, Moriguchi T, Slotnick BM, Hutton A, Salem N.. Olfactory discrimination deficits in n−3 fatty acid-deficient rats. Physiology & behavior 2001; 72: 379-385
  • 404 Gopinath B, Sue CM, Flood VM, Burlutsky G, Mitchell P.. Dietary intakes of fats, fish and nuts and olfactory impairment in older adults. British Journal of Nutrition 2015; 114: 240-247
  • 405 Rondanelli M, Opizzi A, Faliva M, Mozzoni M, Antoniello N, Cazzola R. et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutritional neuroscience 2012; 15: 46-54
  • 406 Yan CH, Rathor A, Krook K, Ma Y, Rotella MR, Dodd RL. et al. Effect of Omega-3 Supplementation in Patients With Smell Dysfunction Following Endoscopic Sellar and Parasellar Tumor Resection: A Multicenter Prospective Randomized Controlled Trial. Neurosurgery 2020; 87: E91-e98
  • 407 Hernandez AK, Woosch D, Haehner A, Hummel T.. Omega-3 supplementation in postviral olfactory dysfunction: a pilot study. Rhinology 2022; 60: 139-144
  • 408 Di Stadio A, D’Ascanio L, Vaira LA, Cantone E, Luca de P, Cingolani C. et al. Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled Clinical Trial. Current neuropharmacology 2022; 20: 2001-2012
  • 409 Drews T, Nehring M, Werner A, Hummel T.. The sense of smell is not strongly affected by ambient temperature and humidity: a prospective study in a controlled environment. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery 2021; 278: 1465-1469
  • 410 Hashem-Dabaghian F, Ali Azimi S, Bahrami M, Latifi S-A, Enayati A, Qaraaty M.. Effect of Lavender (Lavandula angustifolia L.) syrup on olfactory dysfunction in COVID-19 infection: A pilot controlled clinical trial. Avicenna journal of phytomedicine 2022; 12: 1-7
  • 411 Janowitz T, Gablenz E, Pattinson D, Wang TC, Conigliaro J, Tracey K. et al. Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series. Gut 2020; 69: 1592-1597
  • 412 Liu LD, Duricka DL.. Stellate ganglion block reduces symptoms of Long COVID: A case series. Journal of neuroimmunology 2022; 362: 577784
  • 413 Noda T, Shiga H, Yamada K, Harita M, Nakamura Y, Ishikura T. et al. Effects of Tokishakuyakusan on Regeneration of Murine Olfactory Neurons In Vivo and In Vitro. Chemical senses 2019; 44: 327-338
  • 414 Ogawa T, Nakamura K, Yamamoto S, Tojima I, Shimizu T.. Recovery Over Time and Prognostic Factors in Treated Patients with Post-Infectious Olfactory Dysfunction: A Retrospective Study. The. Annals of otology, rhinology, and laryngology 2020; 129: 977-982
  • 415 Vityala Y, Kadyrova A, Zhumabaeva S, Bazarbaeva A, Mamatov S.. Use of B-complex vitamins and olfactory training for treating COVID-19-related anosmia. Clinical case reports 2021; 9: e05069
  • 416 Coleman ER, Grosberg BM, Robbins MS.. Olfactory hallucinations in primary headache disorders: case series and literature review. Cephalalgia: an international journal of headache 2011; 31: 1477-1489
  • 417 Fjaeldstad AW.. Recovery from 3 Years of Daily Olfactory Distortions after Short-Term Treatment with GABA-Analogue. ORL 2022; 1-4
  • 418 Majumdar S, Jones NS, McKerrow WS, Scadding G.. The management of idiopathic olfactory hallucinations: a study of two patients. The Laryngoscope 2003; 113: 879-881
  • 419 Leopold DA, Hornung DE.. Olfactory cocainization is not an effective long-term treatment for phantosmia. Chemical senses 2013; 38: 803-806
  • 420 Leopold DA, Schwob JE, Youngentob SL, Hornung DE, Wright HN, Mozell MM.. Successful treatment of phantosmia with preservation of olfaction. Arch. Otolaryngol. Head Neck Surg. 1991; 117: 1402-1406
  • 421 Saussez S, Vaira LA, Chiesa-Estomba CM, Le Bon S-D, Horoi M, Deiana G. et al. Short-Term Efficacy and Safety of Oral and Nasal Corticosteroids in COVID-19 Patients with Olfactory Dysfunction: A European Multicenter Study. Pathogens (Basel, Switzerland) 2021; 10
  • 422 Hummel T, Heilmann S, Hüttenbriuk KB.. Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. The Laryngoscope 2002; 112: 2076-2080
  • 423 Liu J, Pinheiro-Neto CD, Zhao J, Chen Z, Wang Y.. A novel surgical treatment for long lasting unilateral peripheral parosmia: Olfactory cleft blocking technique. Auris, nasus, larynx 2021; 48: 1209-1213
  • 424 Mudry A, Mills M.. The early history of the cochlear implant: a retrospective. JAMA otolaryngology – head & neck surgery 2013; 139: 446-453
  • 425 Aronsohn E.. Experimentelle Untersuchungen zur Physiologie des Geruchs. Archiv f.Physiologie von Dr.Emil du Bois-Reymond 1886; 321
  • 426 Uziel A.. Stimulation of human olfactory neuro-epithelium by longterm continuous electrical currents.) Stimulation du neuro-epith’lium olfactiff chez l’homme par des courants ‘lectriques continus de longue dur’e. (Fre./Eng.Abstr.). J.Physiol.(Paris) 1973; 66: 409
  • 427 Straschill M, Stahl H, Gorkisch K.. Effects of electrical stimulation of the human olfactory mucosa. Appl. Neurophysiol. 1983; 46: 286-289
  • 428 Ishimaru T, Shimada T, Sakumoto M, Miwa T, Kimura Y, Furukawa M.. Olfactory evoked potential produced by electrical stimulation of the human olfactory mucosa. Chem Senses 1997; 22: 77-81
  • 429 Weiss T, Shushan S, Ravia A, Hahamy A, Secundo L, Weissbrod A. et al. From Nose to Brain: Un-Sensed Electrical Currents Applied in the Nose Alter Activity in Deep Brain Structures. Cerebral cortex (New York, N.Y.: 1991) 2016; 26: 4180-4191
  • 430 Penfield W, Jasper H.. Epilepsy and the functional anatomy of the human brain. 1954
  • 431 Andy OJ.. The amygdala and hippocampus in olfactory aura. Electroencephalogr Clin Neurophysiol 1967; 23: 292
  • 432 Nashold BS, Wilson WP, Slaughter DG.. Sensations evoked by stimulation in the midbrain of man. Journal of neurosurgery 1969; 30: 14-24
  • 433 Hummel T, Jahnke U, Sommer U, Reichmann H, Müller A.. Olfactory function in patients with idiopathic Parkinson’s disease: Effects of deep brain stimulation in the subthalamic nucleus. J. Neural Transm. 2004 Oct 27 [Epub ahead of print]
  • 434 Fonoff ET, Oliveira de YSA, Driollet S, Garrido GJ, Andrade DC, deSallem F. et al. Pet findings in reversible improvement of olfactory dysfunction after STN stimulation in a Parkinson’s disease patient. Movement disorders: official journal of the Movement Disorder Society 2010; 25: 2466-2468
  • 435 Mazzola L, Royet J-P, Catenoix H, Montavont A, Isnard J, Mauguière F.. Gustatory and olfactory responses to stimulation of the human insula. Annals of neurology 2017; 82: 360-370
  • 436 Rose H2020; 2022. https://rose-h2020.eu/ (accessed 03. Oktober 2022)
  • 437 Morrison EE, Graziadei PP.. Transplants of olfactory mucosa in the rat brain I. A light microscopic study of transplant organization. Brain research 1983; 279: 241-245
  • 438 Holbrook EH, DiNardo LJ, Costanzo RM.. Olfactory epithelium grafts in the cerebral cortex: an immunohistochemical analysis. The Laryngoscope 2001; 111: 1964-9
  • 439 Yagi S, Costanzo RM.. Grafting the olfactory epithelium to the olfactory bulb. American journal of rhinology & allergy 2009; 23: 239-243
  • 440 Tsujigiwa H, Nishizaki K, Teshima T, Takeda Y, Yoshinobu J, Takeuchi A. et al. The engraftment of transplanted bone marrow-derived cells into the olfactory epithelium. Brain research 2005; 1052: 10-15
  • 441 Ochi N, Doi K, Uranagase M, Nishikawa T, Katsunuma S, Nibu K.. Bone marrow stem cell transplantation to olfactory epithelium. The Annals of otology, rhinology, and laryngology 2010; 119: 535-540
  • 442 Díaz D, Lepousez G, Gheusi G, Alonso JR, Lledo P-M, Weruaga E.. Bone marrow cell transplantation restores olfaction in the degenerated olfactory bulb. J. Neurosci. 2012; 32: 9053-9058
  • 443 Kurtenbach S, Goss GM, Goncalves S, Choi R, Hare JM, Chaudhari N. et al. Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia. Stem Cell Reports 2019; 12: 1354-1365
  • 444 Dörig P, Gunder N, Witt M, Welge-Lüssen A, Hummel T.. [Future therapeutic strategies for olfactory disorders: electrical stimulation, stem cell therapy, and transplantation of olfactory epithelium-an overview]. HNO 2021; 69: 623-632
  • 445 Croy I, Olgun S, Mueller L, Schmidt A, Muench M, Hummel C. et al. Peripheral adaptive filtering in human olfaction? Three studies on prevalence and effects of olfactory training in specific anosmia in more than 1600 participants. Cortex 2015; 73: 180-187
  • 446 Takagi SF.. A Standardized Olfactometer in Japan A Review Over Ten Years. Ann N Y Acad Sci 1987; 510: 113-118
  • 447 Cardesín A, Alobid I, Benítez P, Sierra E, Haro de J, Bernal-Sprekelsen M. et al. Barcelona Smell Test – 24 (BAST-24): validation and smell characteristics in the healthy Spanish population. Rhinology 2006; 44: 83-89
  • 448 Simmen D, Briner HR, Hess K.. Screeningtest des Geruchssinnes mit Riechdisketten. Laryngorhinootologie 1999; 78: 125-30
  • 449 Lotsch J, Ultsch A, Hummel T.. How Many and Which Odor Identification Items Are Needed to Establish Normal Olfactory Function?. Chemical senses 2016; 41: 339-344