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Semin Neurol 2022; 42(05): 639-657
DOI: 10.1055/a-1958-0710
Review Article

Sleep Disturbances in Neurological Disease: A Target for Intervention

Seva G. Khambadkone
1   Department of Pediatrics, Oregon Health & Science University, Portland, Oregon
,
Sara E. Benjamin
2   Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
3   Johns Hopkins Center for Sleep, Columbia, Maryland
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Abstract

Sleep is a biological function required for neurological and general health, but a significant and under-recognized proportion of the population has disturbed sleep. Here, we briefly overview the biology of sleep, sleep requirements over the lifespan, and common sleep disorders. We then turn our attention to five neurological diseases that significantly contribute to global disease burden and neurology practice makeup: epilepsy, headache, ischemic stroke, Parkinson's disease, and Alzheimer's disease. For each disease, we review evidence that sleep disturbances contribute to disease risk and severity and discuss existing data that addressing sleep disturbances may have disease-modifying effects. We provide recommendations derived from the literature and existing clinical guidelines to facilitate the evaluation and management of sleep disturbances within the context of each neurological disease. Finally, we synthesize identified needs and commonalities into future directions for the field and practical sleep-related recommendations for physicians caring for patients at risk for or currently suffering from neurological disease.

Keywords

sleep - sleep apnea - insomnia - epilepsy - headache - stroke - Parkinson's disease - Alzheimer's disease


Publication History

Accepted Manuscript online:
10 October 2022

Article published online:
13 December 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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