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CC BY-NC-ND 4.0 · Int J Sports Med 2023; 44(03): 206-214
DOI: 10.1055/a-1960-2543
DOI: 10.1055/a-1960-2543
Training & Testing
Changes in Health-related Parameters Associated with Sports Performance Enhancement Drugs
Authors
Abstract
The purpose of this study was to evaluate changes in health-related parameters caused by the administration of anabolic-androgenic steroids and “fat-burning drugs” during a 6-month competition preparation period. The physiological, biochemical, and anthropometric parameters studied included serum cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, aspartate aminotransferase, alanine transaminase, bilirubin, body mass, and percentage of total body fat. Changes in the parameters studied were analyzed at monthly intervals during six months of preparation for competition. The study revealed a continuous increase in body mass, accompanied by a decrease in body fat percentage to the physiologically essential level. Total cholesterol levels remined in the desirable concentration range. The mean levels of triglycerides fluctuated between borderline high and high. Mean high-density lipoprotein cholesterol levels remained within the low range, while low-density lipoprotein cholesterol fluctuated between near-optimal / above-optimal, borderline high, and high levels. Serum levels of aspartate aminotransferase and alanine transaminase remained within the high concentration. The bilirubin concentration remained in the desirable range. The blood nitrogen urea concentration fluctuated between normal and elevated levels. Sports-enhancing drugs analyzed in this study do not have an immediate detrimental impact on the selected biochemical, physiological, and anthropometric parameters that define health.
Publikationsverlauf
Eingereicht: 16. März 2022
Angenommen: 25. Juli 2022
Artikel online veröffentlicht:
02. Dezember 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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Germany
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References
- 1 Celotti F, Negri Cesi P. Anabolic steroids: A review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics. J Steroid Biochem Mol Biol 1992; 43: 469-477
- 2 Phillips SM, Van Loon LJ. Dietary protein for athletes: From requirements to optimum adaptation. J Sports Sci 2011; 29: S29-S38
- 3 Tipton KD, Wolfe RR. Exercise, protein metabolism, and muscle growth. Int J Sport Nutr Exerc Metab 2001; 11: 109-132
- 4 Brand-Saberi B. Genetic and epigenetic control of skeletal muscle development. Ann Anat 2005; 187: 199-207
- 5 Simon P, Striegel H, Aust F. et al. Doping in fitness sports: Estimated number of unreported cases and individual probability of doping. Addiction 2006; 101: 1640-1644
- 6 Havnes IA, Jorstad ML, Wisloff C. Anabolic-androgenic steroid users receiving health-related information; health problems, motivations to quit and treatment desires. Subst Abuse Treat Prev Policy 2019; 14: 20
- 7 Win-May M, Mya-Tu M. The effect of anabolic steroids on physical fitness. J Sports Med Phys Fitness 1975; 15: 266-271
- 8 Hoffman JR, Ratamess NA. Medical issues associated with anabolic steroid use: Are they exaggerated?. J Sports Sci Med 2006; 5: 182-193
- 9 Boregowda K, Joels L, Stephens JW. et al. Persistent primary hypogonadism associated with anabolic steroid abuse. Fertil Steril 2011; 96: e7-e8
- 10 Geraci MJ, Cole M, Davis P. New onset diabetes associated with bovine growth hormone and testosterone abuse in a young body builder. Hum Exp Toxicol 2011; 30: 2007-2012
- 11 Kienbacher G, Maurer-Ertl W, Glehr M. et al. [A case of a tumor simulating expansion caused by anabolic androgen steroids in body building]. Sportverletz Sportschaden 2007; 21: 195-198
- 12 Voelcker V, Sticherling M, Bauerschmitz J. Severe ulcerated ‘bodybuilding acne’ caused by anabolic steroid use and exacerbated by isotretinoin. Int Wound J 2010; 7: 199-201
- 13 Vorona E, Nieschlag E. Adverse effects of doping with anabolic androgenic steroids in competitive athletics, recreational sports and bodybuilding. Minerva Endocrinol 2018; 43: 476-488
- 14 Zubrzycki IZ MW. White book on steroids. Independently published; 2017.
- 15 Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med 2004; 34: 513-554
- 16 Wiacek M, Trabka B, Markuszewski L. et al. Relations between performance enhancement drugs and health-defining parameters during the competition preparation period of World-class bodybuilders. Research Square 2021;
- 17 Bachorik PS, Kwiterovich PO. Apolipoprotein measurements in clinical biochemistry and their utility vis-a-vis conventional assays. Clin Chim Acta 1988; 178: 1-34
- 18 Bachorik PS, Lovejoy KL, Carroll MD. et al. Measurement of apolipoproteins A-I and B during the National Health and Nutrition Examination Survey (NHANES) III. Clin Chem 1994; 40: 1915-1920
- 19 Baim S, Wilson CR, Lewiecki EM. et al. Precision assessment and radiation safety for dual-energy X-ray absorptiometry: Position paper of the International Society for Clinical Densitometry. J Clin Densitom 2005; 8: 371-378
- 20 Zipf G, Chiappa M, Porter KS. et al. National health and nutrition examination survey: Plan and operations, 1999-2010. Vital Health Stat 1 2013; 1-37
- 21 Curtin LR, Mohadjer LK, Dohrmann SM. et al. The National Health and Nutrition Examination Survey: Sample Design, 1999-2006. Vital Health Stat 2 2012; 1-39
- 22 Wolf ST, Jablonski NG, Kenney WL. Examining “race” in physiology. Am J Physiol Heart Circ Physiol 2020; 319: H1409-H1413
- 23 National Health and Nutrition Examination Survey. ANTHROPOMETRY PROCEDURES MANUAL. In Internet: https://wwwn.cdc.gov/nchs/data/nhanes/2003-2004/manuals/BM.pdf;(10/11/2021)
- 24 Lipoprotein Analytical LaboratoryLaboratory Procedure Manual. In Internet: https://wwwn.cdc.gov/nchs/data/nhanes/1999-2000/ labmethods/lab13_met_lipids.pdf; (1/10/2015)
- 25 Collaborative Laboratory Services LLC. Laboratory Procedure Manual. In Internet: https://wwwn.cdc.gov/nchs/data/nhanes/2003-2004/labmethods/l40_c_met_aspartate_aminotransferase.pdf (20/5/2015)
- 26 Collaborative Laboratory Services LLC. Laboratory Procedure Manual. In Internet: https://www.cdc.gov/nchs/data/nhanes/nhanes_07_08/bil_biopro_e_met_dxc800.pdf;(20/5/2015)
- 27 Collaborative Laboratory Services LLC. Laboratory Procedure Manual. In Internet: https://wwwn.cdc.gov/nchs/data/nhanes/2003-2004/labmethods/l40_c_met_blood_urea_nitrogen.pdf (20/5/2015)
- 28 National Institute of Health. BODY COMPOSITION PROCEDURES MANUAL. In Internet: https://wwwn.cdc.gov/nchs/data/nhanes/2003-2004/manuals/BC.pdf (1/4/2013)
- 29 Shapiro SS, Wilk MB, Chen HJ. A comparative study of various tests for normality. J Am Stat Assoc 1968; 63: 1343-1372
- 30 Gastwirth J, Gel Y, Miao W. The impact of levene’s test of equality of variances on statistical theory and practice. Statist Sci 2009; 24: 343-360
- 31 Reed JF, Stark DB. Robust alternatives to traditional analysis of variance: Welch W*, James JI*, James JII*, Brown-Forsythe BF*. Comput Methods Programs Biomed 1988; 26: 233-237
- 32 Welch BL. On linear combinations of several variances. J Am Stat Assoc 1956; 51: 132-148
- 33 Games PA, Howell JF. Pairwise multiple comparison procedures with unequal n’s and/or variances: a monte carlo study. J Educ Behav Stat 1976; 1: 113-125
- 34 Manore M, Meyer NL, Thompson J. Sport Nutrition for Health and Performance. 2nd ed. Champaign, IL: Human Kinetics; 2009
- 35 A Round Table. Body composition. The Physician and Sportsmedicine 1986: 14: 144–162
- 36 Mohamad NV, Soelaiman IN, Chin KY. A concise review of testosterone and bone health. Clin Interv Aging 2016; 11: 1317-1324
- 37 Report of the Expert Panel on Population Strategies for Blood Cholesterol Reduction. (1990). In Internet: https://www.ahajournals. org/doi/pdf/10.1161/01.cir.83.6.2154; (20/11/2021)
- 38 Siest Gr, Schiele Fo, Galteau M-M et al. Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values. Clin Chem 1975; 21: 1077-1087
- 39 Witek K, Ścisłowska J, Turowski D. et al. Total bilirubin in athletes, determination of reference range. Biol Sport 2017; 34: 45-48
- 40 Jacobson SA, Jacobson SA. Clinical Laboratory Medicine for Mental Health Professionals. 1st ed. Arlington, Virginia: American Psychiatric Association Publishing; 2017
- 41 Lippi G, Franchini M, Guidi GC. Doping in competition or doping in sport?. Br Med Bull 2008; 86: 95-107
- 42 Gleaves J, Petróczi A, Folkerts D. et al. Doping prevalence in competitive sport: evidence synthesis with “best practice” recommendations and reporting guidelines from the wada working group on doping prevalence. Sports Med 2021; 51: 1909-1934
- 43 Tenório MCC, Paz CL, Valladares F. et al. Effects of low-to-moderate doses of anabolic steroids on lipid profile and muscle hypertrophy in resistance training practitioners: a systematic review with meta-analysis. Int J Cardiovasc Sci 2021; 34: 531-541
- 44 Halstead LS, Groah SL, Libin A. et al. The effects of an anabolic agent on body composition and pulmonary function in tetraplegia: a pilot study. Spinal Cord 2010; 48: 55-59
- 45 Gapstur SM, Gann PH, Kopp P. et al. Serum androgen concentrations in young men: a longitudinal analysis of associations with age, obesity, and race. The CARDIA male hormone study. Cancer Epidemiol Biomarkers Prev 2002; 11: 1041-1047
- 46 Simon D, Preziosi P, Barrett-Connor E. et al. The influence of aging on plasma sex hormones in men: the telecom study. Am J Epidemiol 1992; 135: 783-791
- 47 Leifke E, Gorenoi V, Wichers C. et al. Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort. Clin Endocrinol (Oxf) 2000; 53: 689-695
- 48 Ng Tang Fui M, Hoermann R, Nolan B. et al. Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial. Sci Rep 2018; 8: 9099
- 49 Snyder PJ, Peachey H, Hannoush P. et al. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J Clin Endocrinol Metab 1999; 84: 1966-1972
- 50 Lunt M, Felsenberg D, Adams J. et al. Population-based geographic variations in DXA bone density in Europe: The EVOS Study. European Vertebral Osteoporosis. Osteoporos Int 1997; 7: 175-189
- 51 Imboden MT, Welch WA, Swartz AM. et al. Reference standards for body fat measures using GE dual energy x-ray absorptiometry in Caucasian adults. PLoS One 2017; 12: e0175110
- 52 Tagarakis CV, Bloch W, Hartmann G. et al. Testosterone-propionate impairs the response of the cardiac capillary bed to exercise. Med Sci Sports Exerc 2000; 32: 946-953
- 53 Baggish AL, Weiner RB, Kanayama G. et al. Cardiovascular toxicity of illicit anabolic-androgenic steroid use. Circulation 2017; 135: 1991-2002
- 54 Tarchalski J, Guzik P, Wysocki H. Correlation between the extent of coronary atherosclerosis and lipid profile. Mol Cell Biochem 2003; 246: 25-30
- 55 Büttner A, Thieme D. Side effects of anabolic androgenic steroids: pathological findings and structure-activity relationships. Handb Exp Pharmacol 2010; 195: 459-484
- 56 Stimac D, Milić S, Dintinjana RD. et al. Androgenic/Anabolic steroid-induced toxic hepatitis. J Clin Gastroenterol 2002; 35: 350-352
- 57 Kafrouni MI, Anders RA, Verma S. Hepatotoxicity associated with dietary supplements containing anabolic steroids. Clin Gastroenterol Hepatol 2007; 5: 809-812
- 58 Baird MF, Graham SM, Baker JS. et al. Creatine-kinase- and exercise-related muscle damage implications for muscle performance and recovery. J Nutr Metab 2012; 2012: 960363
- 59 Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. (2017). In Internet: (20/11/2021)
- 60 Oda SS, El-Ashmawy IM. Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits. Int J Exp Pathol 2012; 93: 172-178
- 61 Tousson E, El-Moghazy M, Massoud A. et al. Physiological and biochemical changes after boldenone injection in adult rabbits. Toxicol Ind Health 2016; 32: 177-182
- 62 O’Connor JJ, Stillions MC, Reynolds WA. et al. Evaluation of boldenone undecylenate as an anabolic agent in horses. Can Vet J 1973; 14: 154-158
- 63 Kung AW, Pang RW, Lauder I. et al. Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism. Clin Chem 1995; 41: 226-231
- 64 Aviram M, Luboshitzky R, Brook JG. Lipid and lipoprotein pattern in thyroid dysfunction and the effect of therapy. Clin Biochem 1982; 15: 62-66
- 65 Dullaart RPF, van Doormaal JJ, Hoogenberg K. et al. Triiodothyronine rapidly lowers plasma lipoprotein (a) in hypothyroid subjects. Neth J Med 1995; 46: 179-184
- 66 Ribeiro MO. Effects of thyroid hormone analogs on lipid metabolism and thermogenesis. Thyroid 2008; 18: 197-203
- 67 Ajala MO, Ogunro PS, Fasanmade OA. Relationship between liver function tests and thyroid hormones in thyroid disorders. Niger Postgrad Med J 2013; 20: 188-192
- 68 Sharma S, Garg A. Clenbuterol induced changes in cholesterol and triglyceride levels of gastrocnemius, pectoralis and heart of rat under work induced stress. Indian J Exp Biol 2003; 41: 1452-1455
- 69 Hartung R, Gerth J, Fünfstück R. et al. End-stage renal disease in a bodybuilder: a multifactorial process or simply doping?. Nephrol Dial Transplant 2001; 16: 163-165
- 70 Abdulredha W. Effect of Clenbuterol using as weight loose on lipid profile and liver enzymes. Iraq Med J 2021; 3. Available at: https:// www.iraqmedj.org/index.php/imj/article/view/641
- 71 Izeboud CA, Hoebe KH, Grootendorst AF. et al. Endotoxin-induced liver damage in rats is minimized by beta 2-adrenoceptor stimulation. Inflamm Res 2004; 53: 93-99
- 72 Abdulredha WS. Effect of Clenbuterol using as weight loose on liver enzymes and lipids profile. Iraq Med J 2019; 3. Available at: https:// www.iraqmedj.org/index.php/imj/article/view/641
- 73 Stromme SB, Meen HD, Aakvaag A. Effects of an androgenic-anabolic steroid on strength development and plasma testosterone levels in normal males. Med Sci Sports 1974; 6: 203-208
- 74 Fontana K, Campos GER, Staron RS. et al. Effects of anabolic steroids and high-intensity aerobic exercise on skeletal muscle of transgenic mice. PloS One 2013; 8: e80909
- 75 Jordan VC. Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer. Br J Pharmacol 2006; 147: S269-S276
- 76 Gutman M, Couillard S, Roy J. et al. Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice. Int J Cancer 2002; 99: 273-278
- 77 Johnson RE, Murad MH. Gynecomastia: Pathophysiology, evaluation, and management. Mayo Clinic proceedings 2009; 84: 1010-1015
- 78 Milionis HJ, Liberopoulos EN, Elisaf MS. Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus. Diabetes Metab 2001; 27: 160-163
- 79 Singh HK, Prasad MS, Kandasamy AK. et al. Tamoxifen-induced hypertriglyceridemia causing acute pancreatitis. J Pharmacol Pharmacother 2016; 7: 38-40
- 80 Liu H, Bravata DM, Olkin I. et al. Systematic review: The effects of growth hormone on athletic performance. Ann Intern Med 2008; 148: 747-758
- 81 Colao A, Vitale G, Pivonello R. et al. The heart: An end-organ of GH action. Eur J Endocrinol 2004; 151: S93-S101
- 82 Colao A. The GH–IGF-I axis and the cardiovascular system: Clinical implications. Clin Endocrinol (Oxf) 2008; 69: 347-358
- 83 Miranda EJ, McIntyre IM, Parker DR. et al. Two deaths attributed to the use of 2,4-dinitrophenol. J Anal Toxicol 2006; 30: 219-222
- 84 Grundlingh J, Dargan PI, El-Zanfaly M. et al. 2,4-dinitrophenol (DNP): A weight loss agent with significant acute toxicity and risk of death. J Med Toxicol 2011; 7: 205-212
- 85 MYTHS AND FACTS ABOUT HUMAN GROWTH HORMONE, B-12, AND OTHER SUBSTANCES. (2008). In Internet: https://www.govinfo.gov/ content/pkg/CHRG-110hhrg47428/html/CHRG-110hhrg47428.htm; (December 20, 2021)
- 86 Waight M, McGuinness W. Case of low dose clenbuterol toxicity. BMJ Case Rep 2016; 2016
- 87 Wibowo E, Pollock PA, Hollis N. et al. Tamoxifen in men: A review of adverse events. Andrology 2016; 4: 776-788
- 88 Grundlingh J, Dargan PI, El-Zanfaly M. et al. 2,4-dinitrophenol (DNP): A weight loss agent with significant acute toxicity and risk of death. J Med Toxicol 2011; 7: 205-212
- 89 Sheffield-Moore M, Urban RJ, Wolf SE. et al. Short-term oxandrolone administration stimulates net muscle protein synthesis in young men. J Clin Endocrinol Metab 1999; 84: 2705-2711
- 90 Fox M, Minot AS, Liddle GW. Oxandrolone: a potent anabolic steroid of novel chemical configuration. J Clin Endocrinol Metab 1962; 22: 921-924
- 91 Karim A, Ranney RE, Zagarella J. et al. Oxandrolone disposition and metabolism in man. Clin Pharmacol Ther 1973; 14: 862-869
- 92 Petróczi A, Ocampo JAV, Shah I. et al. Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): Evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users. Subst Abuse Treat Prev Policy 2015; 10: 39-39